Troponins can it determine the outcome in acute organophosphorus poisoning?

Background: India has shown a sharp rise in the number of suicidal poisoning in the past few years and organo-phosphorus compounds are the most commonly implicated. This is a prospective study done to assess if troponins can be used as a prognostic marker in patients with organophosphate poisoning.Methods: Author conducted a prospective study on 50 patients to measure the level of troponin T and CK-MB on admission and Day 3 in patients with OP poisoning. This was then correlated to the severity of poisoning and also studied for its association with outcomes like respiratory failure or death. The primary endpoints were death and respiratory failure while secondary endpoint was the length of ICU stay.Results: With 0.1 ng/ml taken as the cut off for Troponin- T, and 40 U/L for CK-MB, positive cardiac enzymes were seen only in 10% of the patients, but all the patients in this group developed res-piratory failure. The mean Troponin T and CK-MB levels (0.1142±0.06 ng/ml and 39.14±8.23 U/L) were higher for patients who died when compared to the survivors. A similar picture was seen in patients with respiratory failure (Troponin T 0.0895±0.01 ng/ml and 34.65±11.66 U/L) as compared to those without respiratory failure.Conclusions: The level of cardiac enzymes correlated well with the severity of poisoning, days of ICU stay and outcome, thus suggesting its use as a prognostic indicator of organophosphorus poisoning

Application of remote sensing techniques for locating pelagic fish concentrations along the Kerala coast (SW coast of India) - work done and future prospects

Intensive validation programme on Potential Fishing Zone forecasts carried out by the MARSIS, Central Marine Fisheries Research Institute, Cochin, at 17 selectedjish landing centres along the Kerala coast between November 1995 and May 1996 revealed a positive relationship betwen PFZ and occurence/abundance of commercially important pelagic fishes. An attempt is made to identify possible reasons for the above, based on results of oceanographic itivestigations undertaken in the area and also taking into consideration fish behaviour in relation to environn-ieni based on past data. Future plans for evolving a suitable prediction system for commercially important pelagic fishes in the coastal waters of the mainland and skipjack fishery in the Lakshadweep islands based on PFZ forecasts are also discussed in view of its importance to the artisanal and small mechanised sector fishermen for reducing the searching time and thereby effecting an overall reduction in the cost of fishing

Synthesis, characterization, docking and antimicrobial activity studies of binuclear Co(II) and Ni(II) complexes of bis aroylhydrazone and phenanthroline

ABSTRACT. Schiff base (HL) N1,N3-bis(4-(methylthio)benzylidene)-5-nitrobenzene-1,3-dihydrazide (HL) has been prepared from condensation of 4-(methyl thio)benzaldehyde with 5-nitrobenzene-1,3-dihydrazide. Binucleated mixed ligand complexes of nickel(II) ([Ni2(L)(dmphen)2]Cl2, [Ni2(L)(phen)2]Cl2) and cobalt(II) ([Co2(HL)(dmphen)2]Cl2, [Co2(HL)(phen)2]Cl2) complexes have been synthesized from Schiff base (HL) and 1,10-phenanthroline/2,9-dimethyl-1,10-phenanthroline. The synthesized compounds have been characterized by elemental analysis, 1H-NMR, 13C-NMR, FT-IR, UV-Visible, magnetic moment, SEM, powder X-ray diffraction and molar conductivity measurements. Further, the Schiff base and its metal complexes have been investigated for fluorescence activity and molecular docking studies. In addition, Schiff base and its metal complexes were screened for antimicrobial activity against bacteria: Escherichia coli, Bacillus subtilis and fungi: Sclerotium rolfsii and Macrophomina phaseolina.                     KEY WORDS: Growth inhibitors, Ternary complex, Tuberculosis, Fluorescence activity, Crystal system   Bull. Chem. Soc. Ethiop. 2021, 35(3), 499-511. DOI: https://dx.doi.org/10.4314/bcse.v35i3.

Comment on evidence for new interference phenomena in the decay D+ -> K- pi+ mu+ nu

The experimental determination of low energy pi K scattering phase shifts would assist in determining scattering lengths as well as low energy constants of chiral perturbation theory for which sum rules have been constructed. The FOCUS collaboration has presented evidence for interference pheomena from their analysis of D_l4 decays based on decay amplitudes suitable for a cascade decay D -> K* -> K pi. We point out that if the well-known full five body kinematics are taken into account, pi K scattering phases may be extracted. We also point out that other distributions considered in the context of K_l4 decays can be applied to charm meson decays to provide constraints on violation of |Delta I|=1/2 rule and T-violation.Comment: 9 pages, plain latex; version with minor changes compared to v1 on lepton masses effects, sign error eliminated, clarifying remarks added, one additional ref.; version to appear in Phys. Lett.

Puzzles of excited charm meson masses

We attempt a comprehensive analysis of the low lying charm meson states which present several puzzles, including the poor determination of masses of several non-strange excited mesons. We use the well-determined masses of the ground states and the strange first excited states to `predict' the mass of the non-strange first excited state in the framework of heavy hadron chiral perturbation theory, an approach that is complementary to the well-known analysis of Mehen and Springer. This approach points to values for the masses of these states that are smaller than the experimental determinations. We provide a critical assessment of these mass measurements and point out the need for new experimental information.Comment: 9 pages, 1 figure, accepted for publication in Physics Letters

Injury analysis using Anthropomorphic Test Device under vertical shock loads

Natural and manmade injuries due to terrorism, military weapon and accidents lead to cutting edge research for engineers and clinicians alike. The study of injury and its mechanism can help in predicting the severity of an injury which in turn shall guide the engineers to design safer structures and medical specialists in treating casualties. This article summarizes the various advancements and technologies available in the field of Injury Analysis. The objective of the study is to quantify the levels of an injury which occurs when an Anthropomorphic Test Device is subjected to a given vertical impact load. As a baseline a half sine shock test simulating the vertical impact was carried out on Hybrid III 50th percentile male dummy and injury analysis was done based on the standards prescribed by NATO TR-HFM-090. In the present test the injury analysis predicts that the injury during the loading is well within 10% probability of an AIS 2 or greater (AIS 2+)

Spectroscopic Characterization and Biological Activity of Mixed Ligand Complexes of Ni(II) with 1,10-Phenanthroline and Heterocyclic Schiff Bases

Mixed ligand complexes of Ni(II) with 1,10-phenanthroline (1,10-Phen) and Schiff bases L1(MIIMP); L2(CMIIMP); L3(EMIIMP); L4(MIIMNP); L5(MEMIIMP); L6(BMIIMP); L7(MMIIMP); L8(MIIBD) have been synthesized. These metal chelates have been characterized by elemental analysis, IR, 1H-NMR, 13C-NMR, Mass, UV-Vis, magnetic moments, and thermogravimetric (TG&DTA) analysis. Spectral data showed that the 1,10-phenanthroline act as neutral bidentate ligand coordinating to the metal ion through two nitrogen donor atoms and Schiff bases acts as monobasic bidentate coordinating through NO donor atoms. All Ni(II) complexes appear to have an octahedral geometry. The antimicrobial activity of mixed ligand complexes has been studied by screening against various microorganisms, it is observed that the activity enhances upon coordination. The DNA binding studies have been investigated by UV-Vis spectroscopy, and the experimental results indicate that these complexes bind to CT DNA with the intrinsic binding constant Kb=2.5±0.2×105 M−1. MTT is used to test the anticancer effect of the complexes with HL60 tumor cell. The inhibition ratio was accelerated by increasing the dosage, and it had significant positive correlation with the medication dosage