Вульводиния – мультидисциплинарная проблема

This literature review is devoted to the problem of vulvodynia. The article summarizes information about the etiology and pathogenetic factors of this syndrome, touches the aspects of diagnosis and treatment of this form of chronic genital pain. Despite the prevalence of this pathology, women with pain in the vulva often remain undiagnosed and do not receive adequate therapeutic and psycho-emotional support. Currently, the focus is in searching of the definition, classification, prevalence, pathophysiological factors of occurrence and adequate personalized therapy of this nosology.Обзор литературы посвящен проблеме вульводинии как мультидисциплинарной проблеме. В статье обобщены сведения об этиологии и патогенетических факторах развития заболевания, затронуты аспекты диагностики и лечения данной формы хронической генитальной боли. Несмотря на распространенность патологии, женщины с болью в области вульвы нередко остаются не диагностированными и не получают адекватную терапевтическую и психоэмоциональную поддержку. В настоящее время актуальность представляет поиск определения, классификации, распространенности, патофизиологических факторов возникновения и адекватной персонализированной терапии данной нозологии

Vulvodynia – a multidisciplinary problem

This literature review is devoted to the problem of vulvodynia. The article summarizes information about the etiology and pathogenetic factors of this syndrome, touches the aspects of diagnosis and treatment of this form of chronic genital pain. Despite the prevalence of this pathology, women with pain in the vulva often remain undiagnosed and do not receive adequate therapeutic and psycho-emotional support. Currently, the focus is in searching of the definition, classification, prevalence, pathophysiological factors of occurrence and adequate personalized therapy of this nosology

Vulvovaginal infections in the postantibiotic era. How to avoid aggression?

High incidence of recurring aerobic/nonspecific vaginitis is associated with the formation of stable pathological biofilm. The increasing antibiotic resistance does not allow to eliminate associations of conditionally pathogenic microorganisms and inhibits the growth of lactobacilli. Vaginal use of bacteriophages is a targeted antibiotic therapy. The study showed that multivalent bacteriophage (Sextaphage®) used as vaginal monotherapy is comparable with antibiotic in terms of treatment efficacy of aerobic vaginitis, does not reduce the level of lactobacilli and has a high compliance

Synthesis, structure and bioactivity of novel carboxylate phosphabetaine derivatives with long alkyl chains

© 2018, © 2019 Taylor & Francis Group, LLC. The purpose of the present study was to investigate the antimicrobial activity of novel phosphonium salts: (2-carboxyethyl)(alkyl)diphenylphosphonium iodides and bromides 1–8 and carboxylate phosphabetaines: 3-(alkyldiphenylphosphonio)propanoates 9–16. The in vitro microbiological activity of the synthesized phosphonium compounds against gram-positive, gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. The synthesized phosphonium salts and phosphabetaines showed a high antibacterial and antimycotic activity against human and animal pathogenic microflora. Every newly synthesized compound was characterized by elemental analyses, IR, 1H NMR, 31P NMR spectral studies. The thermal stability was studied by synchronous thermogravimetry and differential scanning calorimetry (TG/DSC)

Synthesis, structure and bioactivity of novel carboxylate phosphabetaine derivatives with long alkyl chains

© 2018, © 2019 Taylor & Francis Group, LLC. The purpose of the present study was to investigate the antimicrobial activity of novel phosphonium salts: (2-carboxyethyl)(alkyl)diphenylphosphonium iodides and bromides 1–8 and carboxylate phosphabetaines: 3-(alkyldiphenylphosphonio)propanoates 9–16. The in vitro microbiological activity of the synthesized phosphonium compounds against gram-positive, gram-negative bacteria and the yeast Candida albicans was determined in comparison to standard agents. The synthesized phosphonium salts and phosphabetaines showed a high antibacterial and antimycotic activity against human and animal pathogenic microflora. Every newly synthesized compound was characterized by elemental analyses, IR, 1H NMR, 31P NMR spectral studies. The thermal stability was studied by synchronous thermogravimetry and differential scanning calorimetry (TG/DSC)