Vulvovaginal infections in the postantibiotic era. How to avoid aggression?

Abstract

High incidence of recurring aerobic/nonspecific vaginitis is associated with the formation of stable pathological biofilm. The increasing antibiotic resistance does not allow to eliminate associations of conditionally pathogenic microorganisms and inhibits the growth of lactobacilli. Vaginal use of bacteriophages is a targeted antibiotic therapy. The study showed that multivalent bacteriophage (Sextaphage®) used as vaginal monotherapy is comparable with antibiotic in terms of treatment efficacy of aerobic vaginitis, does not reduce the level of lactobacilli and has a high compliance