185 research outputs found
A meta-analysis of variables that predict significant intracranial injury in minor head trauma.
BACKGROUND: Previous studies have presented conflicting results regarding the predictive effect of various clinical symptoms, signs, and plain imaging for intracranial pathology in children with minor head injury. AIMS: To perform a meta-analysis of the literature in order to assess the significance of these factors and intracranial haemorrhage (ICH) in the paediatric population. METHODS: The literature was searched using Medline, Embase, Experts, and the grey literature. Reference lists of major guidelines were crosschecked. Control or nested case-control studies of children with head injury who had skull radiography, recording of common symptoms and signs, and head computed tomography (CT) were selected. OUTCOME VARIABLE: CT presence or absence of ICH. RESULTS: Sixteen papers were identified as satisfying criteria for inclusion in the meta-analysis, although not every paper contained data on every correlate. Available evidence gave pooled patient numbers from 1136 to 22 420. Skull fracture gave a relative risk ratio of 6.13 (95% CI 3.35 to 11.2), headache 1.02 (95% CI 0.62 to 1.69), vomiting 0.88 (95% CI 0.67 to 1.15), focal neurology 9.43 (2.89 to 30.8), seizures 2.82 (95% CI 0.89 to 9.00), LOC 2.23 (95% CI 1.20 to 4.16), and Glasgow Coma Scale (GCS) <15 of 5.51 (95% CI 1.59 to 19.0). CONCLUSIONS: There was a statistically significant correlation between intracranial haemorrhage and skull fracture, focal neurology, loss of consciousness, and GCS abnormality. Headache and vomiting were not found to be predictive and there was great variability in the predictive ability of seizures. More information is required about the current predictor variables so that more refined guidelines can be developed. Further research is currently underway by three large study groups
Enhanced triage for patients with suspected cardiac chest pain: the History and Electrocardiogram-only Manchester Acute Coronary Syndromes decision aid.
OBJECTIVES: Several decision aids can 'rule in' and 'rule out' acute coronary syndromes (ACS) in the Emergency Department (ED) but all require measurement of blood biomarkers. A decision aid that does not require biomarker measurement could enhance risk stratification at triage and could be used in the prehospital environment. We aimed to derive and validate the History and ECG-only Manchester ACS (HE-MACS) decision aid using only the history, physical examination and ECG. METHODS: We undertook secondary analyses in three prospective diagnostic accuracy studies that included patients presenting to the ED with suspected cardiac chest pain. Clinicians recorded clinical features at the time of arrival using a bespoke form. Patients underwent serial troponin sampling and 30-day follow-up for the primary outcome of ACS. The model was derived by logistic regression in one cohort and validated in two similar prospective studies. RESULTS: The HE-MACS model was derived in 796 patients and validated in cohorts of 474 and 659 patients. HE-MACS incorporated age, sex, systolic blood pressure plus five historical variables to stratify patients into four risk groups. On validation, 5.5 and 12.1% (pooled total 9.4%) patients were identified as 'very low risk' (potential immediate rule out) with a pooled sensitivity of 99.5% (95% confidence interval: 97.1-100.0%). CONCLUSION: Using only the patient's history and ECG, HE-MACS could 'rule out' ACS in 9.4% of patients while effectively risk stratifying remaining patients. This is a very promising tool for triage in both the prehospital environment and ED. Its impact should be prospectively evaluated in those settings
Performance of triage systems in emergency care: a systematic review and meta-analysis
Objective
To assess and compare the performance
of triage systems for identifying high and low-urgency
patients in the emergency department (ED).
Design Systematic review and meta-analysis.
Data sources EMBASE, Medline OvidSP, Cochrane
central, Web of science and CINAHL databases from 1980
to 2016 with the final update in December 2018.
Eligibility criteria Studies that evaluated an emergency
medical triage system, assessed validity using any
reference standard as proxy for true patient urgency and
were written in English. Studies conducted in low(er)
income countries, based on case scenarios or involving
less than 100 patients were excluded.
Review methods
Reviewers identified studies,
extracted data and assessed the quality of the evidence
independently and in duplicate. The Quality Assessment
of studies of Diagnostic Accuracy included in Systematic
Reviews -2 checklist was used to assess risk of bias. Raw
data were extracted to create 2Ă2 tables and calculate
sensitivity and specificity. ED patient volume and casemix
severity of illness were investigated as determinants of
triage systemsâ performance.
Results
Sixty-six eligible studies evaluated 33 different
triage systems. Comparisons were restricted to the three
triage systems that had at least multiple evaluations using
the same reference standard (Canadian Triage and Acuity
Scale, Emergency Severity Index and Manchester Triage
System). Overall, validity of each triage system to identify
high and low-urgency patients was moderate to good, but
performance was highly variable. In a subgroup analysis,
no clear association was found between ED patient
volume or casemix severity of illness and triage systemsâ
performance.
Conclusions
Established triage systems show a
reasonable validity for the triage of patients at the ED,
but performance varies considerably. Important research
questions that remain are what determinants influence
triage systemsâ performance and how the performance of
existing triage systems can be improved
Ceramics studio to podiatry clinic: The impact of multi-media resources in the teaching of practical skills across diverse disciplines
This paper draws on the experiences of students from two vastly different disciplines to both explore the theoretical background supporting the use of multimedia resources to teach practical skills and provide a qualitative evaluation of student perceptions and experiences of using bespoke resources. Within ceramics and podiatry, practical skills are traditionally taught via an apprenticeship model within small groups. We explore the practical and pedagogic benefits of developing bespoke multimedia resources to teach practical skills, identifying common themes from these disparate discipline areas. Student focus groups revealed that, practically, the opportunity for repeated viewing at convenient times promoted less reliance on lecturers and better preparation prior to practical demonstrations. Pedagogically, time for reflection and sense making underpinned an increase in confidence which in turn led to increased creativity. The student voice was also used to identify recommendations and challenges driving future change
Exploring perceptions of parents on the use of emergency department on-site primary care services for the treatment of children with non-urgent conditions
Objective:
To understand the reasons parents of children with minor conditions attend the
Childrenâs Emergency Department (ED), and their views about on-site paediatric
same day care (SDC) service as an alternative treatment centre.
Method:
A cross-sectional survey of parents attending an inner-city, district general hospital
childrenâs ED, with children aged under 16 years old who were allocated to low triage
categories. A convenience sample of 58 parents of 58 children were recruited.
Results:
All the 58 responses were analysed. Incomplete questionnaires were not excluded.
47% of attendances were because of minor injury. Most presentations were within 24
hours of the injury or illness. 72% of parents were employed. 91% were registered
with a General Practitioner (GP). 29% contacted a GP before the ED visit. The
majority of participants who contacted a GP were referred to the ED; others were
advised to wait to see if the childâs condition improved and to attend the ED if there
were any concerns or the child deteriorated in any way. 50% of those that did not
contact GP said the GP surgery was closed and 8% felt the GP could not help. 90%
of parents perceived their childâs condition as urgent requiring immediate treatment.
33% of parents said they would be happy for their children to be treated at an on-site
Same Day Care (SDC) Centre.
Conclusions:
The study showed limited access to GP services in the community and
dissatisfaction with community services and perceived urgency of treatment
prompted parents of children with minor conditions to attend the ED. This could
mean significant ED attendance by children with minor conditions. The majority of
the parents in the study would welcome an on-site paediatric SDC if appropriate to
meet their childrenâs care needs. Establishing an on-site SDC may help relieve the
ED pressures to attend to more clinically urgent and emergency cases
Bypassing nearest hospital for more distant neuroscience care in head-injured adults with suspected traumatic brain injury: findings of the head injury transportation straight to neurosurgery (HITS-NS) pilot cluster randomised trial
OBJECTIVE: Reconfiguration of trauma services, with direct transport of patients with traumatic brain injury (TBI) to specialist neuroscience centres (SNCs)-bypassing non-specialist acute hospitals (NSAHs), could improve outcomes. However, delays in stabilisation of airway, breathing and circulation (ABC) may worsen outcomes when compared with selective secondary transfer from nearest NSAH to SNC. We conducted a pilot cluster randomised controlled trial to determine the feasibility and plausibility of bypassing suspected patients with TBI -directly into SNCs-producing a measurable effect. SETTING: Two English Ambulance Services. PARTICIPANTS: 74 clusters (ambulance stations) were randomised within pairs after matching for important characteristics. Clusters enrolled head-injured adults-injured nearest to an NSAH-with internationally accepted TBI risk factors and stable ABC. We excluded participants attended by Helicopter Emergency Medical Services or who were injured more than 1âhour by road from nearest SNC. INTERVENTIONS: Intervention cluster participants were transported directly to an SNC bypassing nearest NSAH; control cluster participants were transported to nearest NSAH with selective secondary transfer to SNC. OUTCOMES: Trial recruitment rate (target n=700 per annum) and percentage with TBI on CT scan (target 80%) were the primary feasibility outcomes. 30-day mortality, 6-month Extended Glasgow Outcome Scale and quality of life were secondary outcomes. RESULTS: 56 ambulance station clusters recruited 293 patients in 12 months. The trial arms were similar in terms of age, conscious level and injury severity. Less than 25% of recruited patients had TBI on CT (n=70) with 7% (n=20) requiring neurosurgery. Complete case analysis showed similar 30-day mortality in the two trial arms (control=8.8 (2.7-14.0)% vs intervention=9.4(2.3-14.0)%). CONCLUSION: Bypassing patients with suspected TBI to SNCs gives an overtriage (false positive) ratio of 13:1 for neurosurgical intervention and 4:1 for TBI. A measurable effect from a full trial of early neuroscience care following bypass is therefore unlikely. TRIAL REGISTRATION NUMBER: ISRCTN68087745
Making a Difference: A Qualitative Study on Care and Priority Setting in Health Care
The focus of the study is the conflict between care and concern for particular patients, versus considerations that take impartial considerations of justice to be central to moral deliberations. To examine these questions we have conducted qualitative interviews with health professionals in Norwegian hospitals. We found a value norm that implicitly seemed to overrule all others, the norm of âmaking a difference for the patientsâ. We will examine what such a statement implies, aiming to shed some light over moral dilemmas interwoven in bedside rationing
Communication between secondary and primary care following self-harm: are National Institute of Clinical Excellence (NICE) guidelines being met?
<p>Abstract</p> <p>Background</p> <p>Most patients contact their general practitioner (GP) following presentation to an Emergency Department (ED) after a self-harm incident, and strategies to help GPs manage these patients include efficient communication between services. The aim of this study was to assess the standard of documentation and communication to primary care from secondary care as recommended by the National Institute of Clinical Excellence (NICE) guidelines on the short-term management of people who self-harm.</p> <p>Methods</p> <p>An audit of medical records (ED and Psychiatric) on people aged 16 years and over who had presented to the ED following self-harm, benchmarked according to government guidelines, was performed. Data were collected over a 4-week period at a general teaching hospital.</p> <p>Results</p> <p>We collected data on 93 consecutive episodes of self-harm; 62% of episodes were communicated to primary care, 58% of these communications were within 24 h and most within 3 days. Patient identifying details and follow-up arrangements were specified in most cases. Communication via psychiatric staff was most detailed. ED clinicians provided few communications and were of limited content. Communication with the patient's GP was not made in half of those cases seen by a mental health specialist.</p> <p>Conclusion</p> <p>Government guidelines are only partially being met. Reliance on communication by ED staff would leave a substantial proportion of patients discharged from the ED with no or minimal communication to primary care. Psychiatric services need to improve the rate of communication to the patient's GP following assessment A national sample of National Health Service (NHS) trusts would establish if this is a problem elsewhere.</p
Aquatic therapy for boys with Duchenne muscular dystrophy (DMD): an external pilot randomised controlled trial
Background: Standard treatment of Duchenne muscular dystrophy (DMD) includes regular physiotherapy. There
are no data to show whether adding aquatic therapy (AT) to land-based exercises helps maintain motor function.
We assessed the feasibility of recruiting and collecting data from boys with DMD in a parallel-group pilot randomised
trial (primary objective), also assessing how intervention and trial procedures work.
Methods: Ambulant boys with DMD aged 7â16 years established on steroids, with North Star Ambulatory
Assessment (NSAA) score âĽ8, who were able to complete a 10-m walk test without aids or assistance, were
randomly allocated (1:1) to 6 months of either optimised land-based exercises 4 to 6 days/week, defined by
local community physiotherapists, or the same 4 days/week plus AT 2 days/week. Those unable to commit to a
programme, with >20% variation between NSAA scores 4 weeks apart, or contraindications to AT were excluded.
The main outcome measures included feasibility of recruiting 40 participants in 6 months from six UK centres,
clinical outcomes including NSAA, independent assessment of treatment optimisation, participant/therapist views
on acceptability of intervention and research protocols, value of information (VoI) analysis and cost-impact analysis.
Results: Over 6 months, 348 boys were screened: most lived too far from centres or were enrolled in other trials;
12 (30% of the targets) were randomised to AT (n = 8) or control (n = 4). The mean change in NSAA at 6 months
was â5.5 (SD 7.8) in the control arm and â2.8 (SD 4.1) in the AT arm. Harms included fatigue in two boys, pain in
one. Physiotherapists and parents valued AT but believed it should be delivered in community settings. Randomisation
was unattractive to families, who had already decided that AT was useful and who often preferred to enrol in drug
studies. The AT prescription was considered to be optimised for three boys, with other boys given programmes
that were too extensive and insufficiently focused. Recruitment was insufficient for VoI analysis.
Conclusions: Neither a UK-based RCT of AT nor a twice weekly AT therapy delivered at tertiary centres is feasible.
Our study will help in the optimisation of AT service provision and the design of future research.
Trial registration: ISRCTN4100295
The Anticoagulation of Calf Thrombosis (ACT) project: study protocol for a randomized controlled trial
<p>Abstract</p> <p>Background</p> <p>Half of all lower limb deep vein thrombi (DVT) in symptomatic ambulatory patients are located in the distal (calf) veins. While proximal disease warrants therapeutic anticoagulation to reduce the associated risks, distal DVT often goes untreated. However, a proportion of untreated distal disease will undoubtedly propagate or embolize. Concern also exists that untreated disease could lead to long-term post thrombotic changes. Currently, it is not possible to predict which distal thrombi will develop such complications. Whether these potential risks outweigh those associated with unrestricted anticoagulation remains unclear. The Anticoagulation of Calf Thrombosis (ACT) trial aims to compare therapeutic anticoagulation against conservative management for patients with acute symptomatic distal deep vein thrombosis.</p> <p>Methods</p> <p>ACT is a pragmatic, open-label, randomized controlled trial. Adult patients diagnosed with acute distal DVT will be allocated to either therapeutic anticoagulation or conservative management. All patients will undergo 3 months of clinical and assessor blinded sonographic follow-up, followed by 2-year final review. The project will commence initially as an external pilot study, recruiting over a 16-month period at a single center to assess feasibility measures and clinical event rates. Primary outcome measures will assess feasibility endpoints. Secondary clinical outcomes will be collected to gather accurate data for the design of a definitive clinical trial and will include: (1) a composite endpoint combining thrombus propagation to the popliteal vein or above, development of symptomatic pulmonary embolism or sudden death attributable to venous thromboembolic disease; (2) the incidence of major and minor bleeding episodes; (3) the incidence of post-thrombotic leg syndrome at 2 years using a validated screening tool; and (4) the incidence of venous thromboembolism (VTE) recurrence at 2 years.</p> <p>Discussion</p> <p>The ACT trial will explore the feasibility of comparing therapeutic anticoagulation to conservative management in acute distal DVT, within a modern cohort. We also aim to provide contemporary data on clot propagation, bleeding rates and long-term outcomes within both groups. These results will inform the conduct of a definitive study if feasibility is established.</p> <p>Trial registration</p> <p>Current Controlled Trials <a href="http://www.controlled-trials.com/ISRCTN75175695">ISRCTN75175695</a></p
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