The effects of lifestyle and diet on gut microbiota composition, inflammation and muscle performance in our aging society

Living longer is associated with an increased risk of chronic diseases, including impairments of the musculoskeletal and immune system as well as metabolic disorders and certain cancers, each of which can negatively affect the relationship between host and microbiota up to the occurrence of dysbiosis. On the other hand, lifestyle factors, including regular physical exercise and a healthy diet, can affect skeletal muscle and immune aging positively at all ages. Accordingly, health benefits could partly depend on the effect of such interventions that influence the biodiversity and functionality of intestinal microbiota. In the present review, we first discuss the physiological effects of aging on the gut microbiota, immune system, and skeletal muscle. Secondly, we describe human epidemiological evidence about the associations between physical activity and fitness and the gut microbiota composition in older adults. The third part highlights the relevance and restorative mechanisms of immune protection through physical activity and specific exercise interventions during aging. Fourth, we present important research findings on the effects of exercise and protein as well as other nutrients on skeletal muscle performance in older adults. Finally, we provide nutritional recommendations to prevent malnutrition and support healthy active aging with a focus on gut microbiota. Key nutrition‐related concerns include the need for adequate energy and protein intake for preventing low muscle mass and a higher demand for specific nutrients (e.g., dietary fiber, polyphenols and polyunsaturated fatty acids) that can modify the composition, diversity, and metabolic capacity of the gut microbiota, and may thus provide a practical means of enhancing gut and systemic immune function

A subaqueous hazard map for earthquake-triggered landslides in Lake Zurich, Switzerland

The awareness of geohazards in the subaqueous environment has steadily increased in the past years and there is an increased need to assess these hazards in a quantitative sense. Prime examples are subaqueous landslides, which can be triggered by a number of processes including earthquakes or human activities, and which may impact offshore and onshore infrastructure and communities. In the literature, a plenitude of subaqueous landslide events are related to historical earthquakes, including cases from lakes in Switzerland. Here, we present an approach for a basin-wide earthquake-triggered subaquatic landslide hazard assessment for Lake Zurich, which is surrounded by a densely populated shoreline. Our analysis is based on high-resolution sediment-mechanical and geophysical input data. Slope stabilities are calculated with a grid-based limit equilibrium model on an infinite slope, which uses Monte Carlo sampled input data from a sediment- mechanical stratigraphy of the lateral slopes. Combined with probabilistic ground-shaking forecasts from a recent national seismic hazard analysis, subaquatic earthquake-triggered landslide hazard maps are constructed for different mean return periods, ranging from 475 to 9975 years. Our results provide a first quantitative landslide hazard estimation for the lateral slopes in Lake Zurich. Furthermore, a back-analysis of a case-study site indicates that pseudostatic accelerations in the range between 0.04 and 0.08 g were needed to trigger a well-investigated subaqueous landslide, dated to *2210 cal. years B.P

A co-simulation approach using powerfactory and matlab/simulink to enable validation of distributed control concepts within future power systems

In power network analysis it is increasingly desirable to implement controller and power systems models within different software environments. This stems from, among other things, an increasing influence of new and distrib-uted control functions within smart grids and a growing influence of market operations. The computation time re-sulting from use of multiple simulation environments can cause significant delays and constrain the number of scenarios considered. This paper introduces and com-pares several techniques for integrating external control system models into power systems models for time do-main simulations. In particular, a new technique is reported in this paper for PowerFactory-MATLAB/Simulink co-simulation interfaces, which offers a significant advantage over alternative methods in terms of the reduction in simulation runtimes and flexi-bility for the end user

Historical-institutionalist perspectives on the development of the EU budget system

The EU budget has only recently started to feature in theories of European integration. Studies typically adopt a historical-institutionalist framework, exploring notions such as path dependency. They have, however, generally been rather aggregated, or coarse-grained, in their approach. The EU budget has thus been treated as a single entity rather than a series of inter-linked institutions. This paper seeks to address these lacunae by adopting a fine-grained approach. This enables us to emphasize the connections that exist between EU budgetary institutions, in both time and space. We show that the initial set of budgetary institutions was unable, over time, to achieve consistently their treaty-based objectives. In response, rather than reform these institutions at potentially high political cost, additional institutions were layered on top of the extant structures. We thus demonstrate how some EU budgetary institutions have remained unchanged, whilst others have been added or changed over time

Topological properties of a non-Hermitian quasi-one-dimensional chain with a flat band

We investigate the spectral properties of a non-Hermitian quasi-one-dimensional lattice in two possible dimerization configurations. Specifically, we focus on a non-Hermitian diamond chain that presents a zero-energy flat band. The flat band originates from wave interference and results in eigenstates with a finite contribution only on two sites of the unit cell. To achieve the non-Hermitian characteristics, we introduce non-reciprocal intrasite hopping terms in the chain. This leads to the accumulation of eigenstates on the boundary of the system, known as the non-Hermitian skin effect. Despite this accumulation of eigenstates, for one of the two possible configurations, we can characterize the presence of non-trivial edge states at zero energy by a real-space topological invariant known as the biorthogonal polarization. We show that this invariant, evaluated using the destructive interference method, characterizes the non-trivial phase of the non-Hermitian diamond chain. For the other possible non-Hermitian configuration, we find that there is a finite quantum metric associated with the flat band. Additionally, we observe the skin effect despite having the system a purely real or imaginary spectrum. For both configurations, we show that two non- Hermitian diamond chains can be mapped into two models of the Su-Schrieffer-Heeger chains, either non-Hermitian and Hermitian, in the presence of a flat band. This mapping allows us to draw valuable insights into the behavior and properties of these systems.Comment: 14 pages, 9 figure

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice

Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals, there are two converging apoptosis pathways: the ‘extrinsic’ pathway, which is triggered by engagement of cell surface ‘death receptors’ such as Fas/APO-1; and the ‘intrinsic’ pathway, which is triggered by diverse cellular stresses, and is regulated by prosurvival and pro-apoptotic members of the Bcl-2 family of proteins. Pro-survival Mcl-1, which can block activation of the proapoptotic proteins, Bax and Bak, appears critical for the survival and maintenance of multiple haemopoietic cell types. To investigate the impact on haemopoiesis of simultaneously inhibiting both apoptosis pathways, we introduced the vavP-Mcl-1 transgene, which causes overexpression of Mcl-1 protein in all haemopoietic lineages, into Faslpr/lpr mice, which lack functional Fas and are prone to autoimmunity. The combined mutations had a modest impact on myelopoiesis, primarily an increase in the macrophage/monocyte population in Mcl-1tg/lpr mice compared with lpr or Mcl-1tg mice. The impact on lymphopoiesis was striking, with a marked elevation in all major lymphoid subsets, including the non-conventional double-negative (DN) T cells (TCRβ+ CD4– CD8– B220+ ) characteristic of Faslpr/lpr mice. Of note, the onset of autoimmunity was markedly accelerated in Mcl-1tg/lpr mice compared with lpr mice, and this was preceded by an increase in immunoglobulin (Ig)-producing cells and circulating autoantibodies. This degree of impact was surprising, given the relatively mild phenotype conferred by the vavP-Mcl-1 transgene by itself: a two- to threefold elevation of peripheral B and T cells, no significant increase in the non-conventional DN T-cell population and no autoimmune disease. Comparison of the phenotype with that of other susceptible mice suggests that the development of autoimmune disease in Mcl-1tg/lpr mice may be influenced not only by Ig-producing cells but also other haemopoietic cell types