Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat

Angiotensin-converting enzyme 2 (ACE 2) in the heart including its sex dependency in the hypertensive heart, has not been much studied compared to ACE. In the present study, we used the Dahl salt-sensitive rat exposed to fructose and salt to model a hypertensive phenotype in males, females, and ovariectomized females. Blood pressure was measured by the tale-cuff technique in the conscious state. Expression of RAS-related genes ACE, ACE2, angiotensin II receptor type 1, Mas1, and CMA1 in the heart were quantified. The results revealed small but significant differences between male and female groups. The main results indicate the presence of a male preponderance for an increase in ACE and ACE2 gene expression. The results are in accordance with the role of androgens or male chromosomal complement in controlling the expression of the two ACE genes

Quasi-Local Gravitational Energy

A dynamically preferred quasi-local definition of gravitational energy is given in terms of the Hamiltonian of a `2+2' formulation of general relativity. The energy is well-defined for any compact orientable spatial 2-surface, and depends on the fundamental forms only. The energy is zero for any surface in flat spacetime, and reduces to the Hawking mass in the absence of shear and twist. For asymptotically flat spacetimes, the energy tends to the Bondi mass at null infinity and the \ADM mass at spatial infinity, taking the limit along a foliation parametrised by area radius. The energy is calculated for the Schwarzschild, Reissner-Nordstr\"om and Robertson-Walker solutions, and for plane waves and colliding plane waves. Energy inequalities are discussed, and for static black holes the irreducible mass is obtained on the horizon. Criteria for an adequate definition of quasi-local energy are discussed.Comment: 16 page

Two dimensional Sen connections and quasi-local energy-momentum

The recently constructed two dimensional Sen connection is applied in the problem of quasi-local energy-momentum in general relativity. First it is shown that, because of one of the two 2 dimensional Sen--Witten identities, Penrose's quasi-local charge integral can be expressed as a Nester--Witten integral.Then, to find the appropriate spinor propagation laws to the Nester--Witten integral, all the possible first order linear differential operators that can be constructed only from the irreducible chiral parts of the Sen operator alone are determined and examined. It is only the holomorphy or anti-holomorphy operator that can define acceptable propagation laws. The 2 dimensional Sen connection thus naturally defines a quasi-local energy-momentum, which is precisely that of Dougan and Mason. Then provided the dominant energy condition holds and the 2-sphere S is convex we show that the next statements are equivalent: i. the quasi-local mass (energy-momentum) associated with S is zero; ii.the Cauchy development $D(\Sigma)$ is a pp-wave geometry with pure radiation ($D(\Sigma)$ is flat), where $\Sigma$ is a spacelike hypersurface whose boundary is S; iii. there exist a Sen--constant spinor field (two spinor fields) on S. Thus the pp-wave Cauchy developments can be characterized by the geometry of a two rather than a three dimensional submanifold.Comment: 20 pages, Plain Tex, I

Age- and Sex-Associated Effects on Acute-Phase Proteins in Göttingen Minipigs

Göttingen minipigs are a useful model for diseases having an inflammatory component, and the associated use of acute-phase proteins (APP) as biomarkers of inflammation warrants establishment of their reference ranges. The objective of this study was to establish reference values for selected APP in Göttingen minipigs and to investigate the effects of age, sex, and various stimuli on these ranges. Serum concentrations of C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin, pig major acute-phase protein (PMAP), albumin, and porcine α-1 acid glycoprotein (PAGP) were evaluated in 4 age groups (6, 16, 24 and 40–48 wk) of male and female Göttingen minipigs. In addition, minipigs were tested under 2 housing conditions, after acute LPS challenge, and after diet-induced obesity with and without mild diabetes. Changing the pigs to a new environment induced significant increases in CRP, PMAP, haptoglobin and PAGP and a decrease in albumin. An acute LPS stimulus increased CRP, PMAP, haptoglobin, and SAA; PAGP was unchanged and albumin decreased. Obese pigs with and without diabetes showed increases in CRP and PAGP, albumin decreased, and haptoglobin and SAA were unchanged. PMAP was increased only in obese pigs without diabetes. In conclusion, reference values for CRP, PMAP, haptoglobin, SAA, PAGP and albumin were established for male and female Göttingen minipigs of different ages. These APP were influenced by age and sex, underlining the importance of considering these factors when designing and interpreting studies including aspects of inflammation. In addition, an APP response was verified after both acute and chronic stimuli

How children eat may contribute to rising levels of obesity children's eating behaviours: An intergenerational study of family influences

The term ‘obesogenic environment’ is rapidly becoming part of common phraseology. However, the influence of the family and the home environment on children's eating behaviours is little understood. Research that explores the impact of this micro environment and intergenerational influences affecting children's eating behaviours is long overdue. A qualitative, grounded theory approach, incorporating focus groups and semi-structured interviews, was used to investigate the family environment and specifically, the food culture of different generations within families. What emerged was a substantive theory based on ‘ordering of eating’ that explains differences in eating behaviours within and between families. Whereas at one time family eating was highly ordered and structured, typified by the grandparent generation, nowadays family eating behaviours are more haphazard and less ordered, evidenced by the way the current generation of children eat. Most importantly, in families with an obese child eating is less ordered compared with those families with a normal weight child. Ordering of eating' is a unique concept to emerge. It shows that an understanding of the eating process is crucial to the development and improvement of interventions targeted at addressing childhood obesity within the family context

COVID-19 information disorder:six types of harmful information during the pandemic in Europe

{Sten Hansson and Kati Orru and Sten Torpan and Asta Bäck and Austeja Kazemekaityte and Sunniva Frislid Meyer and Johanna Ludvigsen and Lucia Savadori and Alessandro Galvagni and Ala Pigrée}, {COVID-19 information disorder: six types of harmful information during the pandemic in Europe}, {Journal of Risk Research}, {24}, {3-4}, {380-393}, {2021}, {Routledge}, {10.1080/13669877.2020.1871058}, { https://doi.org/10.1080/13669877.2020.1871058}The outbreak of a novel coronavirus disease COVID-19 propelled the creation, transmission, and consumption of false information – unverified claims, misleading statements, false rumours, conspiracy theories, and so on – all around the world. When various official or unofficial sources issue erroneous, misleading or contradicting information during a crisis, people who are exposed to this may behave in ways that cause harm to the health and well-being of themselves or others, e.g., by not taking appropriate risk reducing measures or blaming or harassing vulnerable groups. To work towards a typology of informational content that may increase people’s vulnerability in the context of the coronavirus pandemic, we explored 98 instances of potentially harmful information that spread in six European countries – France, Italy, Norway, Finland, Lithuania, and Estonia – between March and May 2020. We suggest that during the pandemic, exposure to harmful information may have made people more vulnerable in six ways: (1) by discouraging appropriate protective actions against catching/spreading the virus, (2) by promoting the use of false (or harmful) remedies against the virus, (3) by misrepresenting the transmission mechanisms of the virus, (4) by downplaying the risks related to the pandemic, (5) by tricking people into buying fake protection against the virus or into revealing their confidential information, and (6) by victimising the alleged spreaders of the virus by harassment/hate speech. The proposed typology can be used to guide the development of risk communication plans to address each of these information-related vulnerabilities.publishedVersio

Two dimensional Sen connections in general relativity

The two dimensional version of the Sen connection for spinors and tensors on spacelike 2-surfaces is constructed. A complex metric $\gamma_{AB}$ on the spin spaces is found which characterizes both the algebraic and extrinsic geometrical properties of the 2-surface $\$$. The curvature of the two dimensional Sen operator $\Delta_e$ is the pull back to $\$$ of the anti-self-dual part of the spacetime curvature while its `torsion' is a boost gauge invariant expression of the extrinsic curvatures of $\$$. The difference of the 2 dimensional Sen and the induced spin connections is the anti-self-dual part of the `torsion'. The irreducible parts of $\Delta_e$ are shown to be the familiar 2-surface twistor and the Weyl--Sen--Witten operators. Two Sen--Witten type identities are derived, the first is an identity between the 2 dimensional twistor and the Weyl--Sen--Witten operators and the integrand of Penrose's charge integral, while the second contains the `torsion' as well. For spinor fields satisfying the 2-surface twistor equation the first reduces to Tod's formula for the kinematical twistor.Comment: 14 pages, Plain Tex, no report numbe

A Wellspring for New Pedagogical Approaches: The Importance of Foundation Years for Universities

In the context of increasing hostility towards the value of foundation years in universities, this article seeks to emphasise their value in helping develop new pedagogical approaches which can be replicated at all levels of undergraduate study. Owing to the diverse nature of foundation years, practitioners who work on these courses develop a range of innovations to promote engagement, attendance, attainment and retention. The impact of the Covid-19 pandemic on the educational experience of many young people, combined with the implementation of stringent performance indicators by the Office for Students makes these strategies more important than ever in supporting students at all levels of undergraduate study

Lagrangian and Hamiltonian for the Bondi-Sachs metrics

We calculate the Hilbert action for the Bondi-Sachs metrics. It yields the Einstein vacuum equations in a closed form. Following the Dirac approach to constrained systems we investigate the related Hamiltonian formulation.Comment: 8 page

Chronology Protection and Non-Naked Singularity

We test the chronology protection conjecture in classical general relativity by investigating finitely vicious space-times. First we present singularity theorems in finitely vicious space-times by imposing some restrictions on the chronology violating sets. In the theorems we can refer to the location of an occurring singularity and do not assume any asymptotic conditions such as the existence of null infinities. Further introducing the concept of a non-naked singularity, we show that a restricted class of chronology violations cannot arise if all occurring singularities are the non-naked singularities. Our results suggest that the causal feature of the occurring singularities is the key to prevent the appearance of causality violation.Comment: 17 pages including 3 eps figures. Accepted for publication in Classical and Quantum Gravit