7,958 research outputs found

    Dopamine receptors in a songbird brain.

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    Dopamine is a key neuromodulatory transmitter in the brain. It acts through dopamine receptors to affect changes in neural activity, gene expression, and behavior. In songbirds, dopamine is released into the striatal song nucleus Area X, and the levels depend on social contexts of undirected and directed singing. This differential release is associated with differential expression of activity-dependent genes, such as egr1 (avian zenk), which in mammalian brain are modulated by dopamine receptors. Here we cloned from zebra finch brain cDNAs of all avian dopamine receptors: the D1 (D1A, D1B, D1D) and D2 (D2, D3, D4) families. Comparative sequence analyses of predicted proteins revealed expected phylogenetic relationships, in which the D1 family exists as single exon and the D2 family exists as spliced exon genes. In both zebra finch and chicken, the D1A, D1B, and D2 receptors were highly expressed in the striatum, the D1D and D3 throughout the pallium and within the mesopallium, respectively, and the D4 mainly in the cerebellum. Furthermore, within the zebra finch, all receptors, except for D4, showed differential expression in song nuclei relative to the surrounding regions and developmentally regulated expression that decreased for most receptors during the sensory acquisition and sensorimotor phases of song learning. Within Area X, half of the cells expressed both D1A and D2 receptors, and a higher proportion of the D1A-only-containing neurons expressed egr1 during undirected but not during directed singing. Our findings are consistent with hypotheses that dopamine receptors may be involved in song development and social context-dependent behaviors

    Weak gravitational lensing with the Square Kilometre Array

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    We investigate the capabilities of various stages of the SKA to perform world-leading weak gravitational lensing surveys. We outline a way forward to develop the tools needed for pursuing weak lensing in the radio band. We identify the key analysis challenges and the key pathfinder experiments that will allow us to address them in the run up to the SKA. We identify and summarize the unique and potentially very powerful aspects of radio weak lensing surveys, facilitated by the SKA, that can solve major challenges in the field of weak lensing. These include the use of polarization and rotational velocity information to control intrinsic alignments, and the new area of weak lensing using intensity mapping experiments. We show how the SKA lensing surveys will both complement and enhance corresponding efforts in the optical wavebands through cross-correlation techniques and by way of extending the reach of weak lensing to high redshift.Comment: 19 pages, 6 figures. Cosmology Chapter, Advancing Astrophysics with the SKA (AASKA14) Conference, Giardini Naxos (Italy), June 9th-13th 201

    Practice-Focused, Constructivist Grounded Theory Methodology In Higher Education Leadership Research

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    A growing body of education research considers practices, however there is less focus on a methodology that enables practical analysis of practices. Use of practice theory is growing, particularly in work and organisational studies, but practice focused studies more frequently address theoretical than methodological agenda. This chapter proposes a practice-focused, constructivist grounded theory methodology as one approach which can address this gap. After first considering the ways in which, separately and in combination, practice-theory and constructivist grounded theory can support higher education leadership and management research, the chapter considers implementation of this methodology by drawing on a study into the practice of authority in higher education leadership. It concludes by considering some implications for the ways in which practices can be understood and the affordances and limitations of this methodology.Peer reviewe

    Cosmology with Weak Lensing Surveys

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    Weak gravitational lensing surveys measure the distortion of the image of distant sources due to the deflections of light rays by the fluctuations of the gravitational potential along the line of sight. Since they probe the non-linear matter power spectrum itself at medium redshift such surveys are complimentary to both galaxy surveys (which follow stellar light) and cosmic microwave background observations (which probe the linear regime at high redshift). Ongoing CMB experiments such as WMAP and the future Planck satellite mission will measure the standard cosmological parameters with unprecedented accuracy. The focus of attention will then shift to understanding the nature of dark matter and vacuum energy: several recent studies suggest that lensing is the best method for constraining the dark energy equation of state. During the next 5 year period ongoing and future weak lensing surveys such as the Joint Dark Energy Mission (JDEM, e.g. SNAP) or the Large-aperture Synoptic Survey Telescope (LSST) will play a major role in advancing our understanding of the universe in this direction. In this review article we describe various aspects of weak lensing surveys and how they can help us in understanding our universe.Comment: 15 pages, review article to appear in 2005 Triennial Issue of Phil. Trans.

    Contact of Single Asperities with Varying Adhesion: Comparing Continuum Mechanics to Atomistic Simulations

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    Atomistic simulations are used to test the equations of continuum contact mechanics in nanometer scale contacts. Nominally spherical tips, made by bending crystals or cutting crystalline or amorphous solids, are pressed into a flat, elastic substrate. The normal displacement, contact radius, stress distribution, friction and lateral stiffness are examined as a function of load and adhesion. The atomic scale roughness present on any tip made of discrete atoms is shown to have profound effects on the results. Contact areas, local stresses, and the work of adhesion change by factors of two to four, and the friction and lateral stiffness vary by orders of magnitude. The microscopic factors responsible for these changes are discussed. The results are also used to test methods for analyzing experimental data with continuum theory to determine information, such as contact area, that can not be measured directly in nanometer scale contacts. Even when the data appear to be fit by continuum theory, extracted quantities can differ substantially from their true values

    LOFAR discovery of a 700-kpc remnant radio galaxy at low redshift

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    Remnant radio galaxies represent the final dying phase of radio galaxy evolution, in which the jets are no longer active. Due to their rarity in flux limited samples and the difficulty of identification, this dying phase remains poorly understood and the luminosity evolution largely unconstrained. Here we present the discovery and detailed analysis of a large (700 kpc) remnant radio galaxy with a low surface brightness that has been identified in LOFAR images at 150 MHz. By combining LOFAR data with new follow-up Westerbork observations and archival data at higher frequencies, we investigated the source morphology and spectral properties from 116 to 4850 MHz. By modelling the radio spectrum we probed characteristic timescales of the radio activity. The source has a relatively smooth, diffuse, amorphous appearance together with a very weak central compact core which is associated with the host galaxy located at z=0.051. From our ageing and morphological analysis it is clear that the nuclear engine is currently switched off or, at most, active at a very low power state. The host galaxy is currently interacting with another galaxy located at a projected separation of 15 kpc and a radial velocity offset of 300 km/s. This interaction may have played a role in the triggering and/or shut down of the radio jets. The spectral shape of this remnant radio galaxy differs from the majority of the previously identified remnant sources, which show steep or curved spectra at low to intermediate frequencies. In light of this finding and in preparation for new-generation deep low-frequency surveys, we discuss the selection criteria to be used to select representative samples of these sources.Comment: 10 pages, 6 figures, 5 tables, A&A accepte

    A kinematical approach to gravitational lensing using new formulae for refractive index and acceleration

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    This paper uses the Schwarzschild metric to derive an effective refractive index and acceleration vector that account for relativistic deflection of light rays, in an otherwise classical kinematic framework. The new refractive index and the known path equation are integrated to give accurate results for travel time and deflection angle, respectively. A new formula for coordinate acceleration is derived which describes the path of a massless test particle in the vicinity of a spherically symmetric mass density distribution. A standard ray-shooting technique is used to compare the deflection angle and time delay predicted by this new formula with the previously calculated values, and with standard first order approximations. Finally, the ray shooting method is used in theoretical examples of strong and weak lensing, reproducing known observer-plane caustic patterns for multiple masses.Comment: 11 pages, 7 figures, MNRAS accepte
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