176 research outputs found
How Big Can Anomalous W Couplings Be?
Conventional wisdom has it that anomalous gauge-boson self-couplings can be
at most a percent or so in size. We test this wisdom by computing these
couplings at one loop in a generic renormalizable model of new physics. (For
technical reasons we consider the CP-violating couplings here, but our results
apply more generally.) By surveying the parameter space we find that the
largest couplings (several percent) are obtained when the new particles are at
the weak scale. For heavy new physics we compare our findings with expectations
based on an effective-lagrangian analysis. We find general patterns of induced
couplings which robustly reflect the nature of the underlying physics. We build
representative models for which the new physics could be first detected in the
anomalous gauge couplings.Comment: 40 pages, 11 figures, (dvi file and figures combined into a uuencoded
compressed file), (We correct an error in eq. 39 and its associated figure
(9). No changes at all to the text.), McGill-93/40, UQAM-PHE-93/03,
NEIPH-93-00
A Delayed Black and Scholes Formula I
In this article we develop an explicit formula for pricing European options
when the underlying stock price follows a non-linear stochastic differential
delay equation (sdde). We believe that the proposed model is sufficiently
flexible to fit real market data, and is yet simple enough to allow for a
closed-form representation of the option price. Furthermore, the model
maintains the no-arbitrage property and the completeness of the market. The
derivation of the option-pricing formula is based on an equivalent martingale
measure
A rare case of giant leiomyosarcoma in a filarial scrotum: a case report
Giant leiomyosarcoma of scrotum is a rare tumour. A case of scrotum leiomyosarcoma is presented in a 67 year old patient with scrotal filariasis which was managed successfully with total scrotectomy with bilateral orchidectomy, degloved penis reconstructed with rotation advancement supra pubic fasciocutaneous flap. We made a literature search proving the rarity of this lesion type. Only 36 cases have been described and the first case in a filarial scrotu
Neutral Higgs-Boson Pair Production at Hadron Colliders: QCD Corrections
Neutral Higgs-boson pair production provides the possibility of studying the
trilinear Higgs couplings at future high-energy colliders. We present the QCD
corrections to the gluon-initiated processes in the limit of a heavy top quark
in the loops and the Drell-Yan-like pair production of scalar and pseudoscalar
Higgs particles. The pp cross sections are discussed for LHC energies within
the Standard Model and its minimal supersymmetric extension. The QCD
corrections are large, enhancing the total cross sections significantly.Comment: 26 pages, latex, 9 ps figure
Semi-Groups of Isometries and the Representation and Multiplicity of Weakly Stationary Stochastic Processes
1 online resource (PDF, 27 pages
Resolving early mesoderm diversification through single-cell expression profiling.
In mammals, specification of the three major germ layers occurs during gastrulation, when cells ingressing through the primitive streak differentiate into the precursor cells of major organ systems. However, the molecular mechanisms underlying this process remain unclear, as numbers of gastrulating cells are very limited. In the mouse embryo at embryonic day 6.5, cells located at the junction between the extra-embryonic region and the epiblast on the posterior side of the embryo undergo an epithelial-to-mesenchymal transition and ingress through the primitive streak. Subsequently, cells migrate, either surrounding the prospective ectoderm contributing to the embryo proper, or into the extra-embryonic region to form the yolk sac, umbilical cord and placenta. Fate mapping has shown that mature tissues such as blood and heart originate from specific regions of the pre-gastrula epiblast, but the plasticity of cells within the embryo and the function of key cell-type-specific transcription factors remain unclear. Here we analyse 1,205 cells from the epiblast and nascent Flk1(+) mesoderm of gastrulating mouse embryos using single-cell RNA sequencing, representing the first transcriptome-wide in vivo view of early mesoderm formation during mammalian gastrulation. Additionally, using knockout mice, we study the function of Tal1, a key haematopoietic transcription factor, and demonstrate, contrary to previous studies performed using retrospective assays, that Tal1 knockout does not immediately bias precursor cells towards a cardiac fate.We thank M. de Bruijn, A. Martinez-Arias, J. Nichols and C. Mulas for discussion, the Cambridge Institute for Medical Research Flow Cytometry facility for their expertise in single-cell index sorting, and S. Lorenz from the Sanger Single Cell Genomics Core for supervising purification of Tal1−/− sequencing libraries. ChIP-seq reads were processed by R. Hannah. Research in the authors’ laboratories is supported by the Medical Research Council, Cancer Research UK, the Biotechnology and Biological Sciences Research Council, Bloodwise, the Leukemia and Lymphoma Society, and the Sanger-EBI Single Cell Centre, and by core support grants from the Wellcome Trust to the Cambridge Institute for Medical Research and Wellcome Trust - MRC Cambridge Stem Cell Institute and by core funding from Cancer Research UK and the European Molecular Biology Laboratory. Y.T. was supported by a fellowship from the Japan Society for the Promotion of Science. W.J. is a Wellcome Trust Clinical Research Fellow. A.S. is supported by the Sanger-EBI Single Cell Centre. This work was funded as part of Wellcome Trust Strategic Award 105031/D/14/Z ‘Tracing early mammalian lineage decisions by single-cell genomics’ awarded to W. Reik, S. Teichmann, J. Nichols, B. Simons, T. Voet, S. Srinivas, L. Vallier, B. Göttgens and J. Marioni.This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/nature1863
Role of dietary fatty acids in mammary gland development and breast cancer
Breast cancer is the most common cancer among women worldwide. Estimates suggest up to 35% of cases may be preventable through diet and lifestyle modification. Growing research on the role of fats in human health suggests that early exposure in life to specific fatty acids, when tissues are particularly sensitive to their environment, can have long-term health impacts. The present review examines the role of dietary fat in mammary gland development and breast cancer throughout the lifecycle. Overall, n-3 polyunsaturated fatty acids have promising cancer-preventive effects when introduced early in life, and warrant further research to elucidate the mechanisms of action
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
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