The construction of generalized Dirac operators on the lattice

We discuss the steps to construct Dirac operators which have arbitrary fermion offsets, gauge paths, a general structure in Dirac space and satisfy the basic symmetries (gauge symmetry, hermiticity condition, charge conjugation, hypercubic rotations and reflections) on the lattice. We give an extensive set of examples and offer help to add further structures.Comment: 19 pages, latex, maple code attache

Progress using generalized lattice Dirac operators to parametrize the Fixed-Point QCD action

We report on an ongoing project to parametrize the Fixed-Point Dirac operator for massless quarks, using a very general construction which has arbitrarily many fermion offsets and gauge paths, the complete Clifford algebra and satisfies all required symmetries. Optimizing a specific construction with hypercubic fermion offsets, we present some preliminary results.Comment: Lattice 2000 (Improvement), 9 pages, based on a talk by K.H. and a poster by T.J. References adde

Anatomy of Cirrus Clouds: Results from the Emerald Airborne Campaigns

2000 FLORIDA AVE NW, WASHINGTON, USA, DC, 2000

Free-volume dependent pressure sensitivity of Zr-based bulk metallic glass

Instrumented indentation experiments on a Zr-based bulk metallic glass (BMG) in as-cast, shot-peened and structurally relaxed conditions were conducted to examine the dependence of plastic deformation on its structural state. Results show significant differences in hardness, H, with structural relaxation increasing it and shot peening markedly reducing it, and slightly changed morphology of shear bands around the indents. This effect is in contrast to uniaxial compressive yield strength, σ y, which remains invariant with the change in the structural state of the alloys investigated. The plastic constraint factor, C = H/σ y, of the relaxed BMG increases compared with that of the as-cast glass, indicating enhanced pressure sensitivity upon annealing. In contrast, C of the shot-peened layer was found to be similar to that observed in crystalline metals, indicating that severe plastic deformation could eliminate pressure sensitivity. Microscopic origins for this result, in terms of shear transformation zones and free volume, are discusse

Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background Neoadjuvant treatment plays a crucial role in the therapy of advanced esophageal cancer. However, response to radiochemotherapy varies widely. Proton pump inhibitors (PPIs) have been demonstrated to impact on chemotherapy in a variety of other cancers. We analyzed the impact of PPI treatment on esophageal cancer cell lines, and investigated mechanisms that mediate the effect of PPI treatment in this tumour. Methods We investigated the effect of esomeprazole treatment on cancer cell survival, adhesion, migration and chemotherapy in human adeno-(OE19) and squamous-cell-carcinoma (KYSE410) cell lines. Furthermore, we investigated the effect of PPI treatment on intra-/extracellular pH and on expression of resistance-relevant miRNAs. Results Esomeprazole significantly inhibited tumour cell survival (in a dose-dependent manner), adhesion and migration in both tumour subtypes. Furthermore, esomeprazole augmented the cytotoxic effect of cisplatin and 5-FU in both tumour subtypes. Surprisingly, PPI treatment led to a significant increase of intracellular pH and a decrease of the extracellular pH. Finally, we found esomeprazole affected expression of resistance-relevant miRNAs. Specifically, miR-141 and miR-200b were upregulated, whereas miR-376a was downregulated after PPI treatment in both tumour types. Conclusion Our study demonstrates for the first time that PPIs impact on tumour cell survival, metastatic potential and sensitivity towards chemotherapy in esophageal cancer cell lines. Furthermore, we observed that in this tumour entity, PPIs do not lead to intracellular acidification, but affect the expression of resistance-relevant miRNAs. Keywords: Proton pump inhibitor; PPI; Esophageal cancer; Metastasis; Chemotherapy; Resistance; microRN

35 million-year-old solid-wood-borer beetle larvae support the idea of stressed Eocene amber forests

Eocene amber is an important window into the past about 35 million years ago. The large quantities of resin produced by this forest of the past, resulting in amber, triggered the idea of a forest under stress. Recent findings of higher abundances of hoverfly larvae in Eocene amber, in the modern fauna often associated with wood-borer larvae, provided a hint that wood-borer larvae may have contributed to this stress. Yet, so far only few such larvae have been reported. We have compiled a dozen additional wood-borer larvae in amber, including a giant one of at least 35 mm length in Rovno amber. Heavily damaged fossils furthermore indicate that larger larvae of this type were prone to oxidation and that, at least some, enigmatic tube-like tunnels in larger amber pieces may represent remains of large wood-borer larvae. This find strongly indicates that wood-borer larvae were not rare, but common in the Eocene amber forest, which is compatible with the high abundances of hoverfly larvae and further supports the idea of a forest under stress. Whether the possible higher abundances of wood-borer larvae were the cause of the stress or a symptom of an already stressed forest remains so far unclear

Critical magnetic fluctuations induced superconductivity and residual density of states in CeRhIn5CeRhIn_5 superconductor

We propose the multiband extension of the spin-fermion model to address the superconducting d-wave pairing due to magnetic interaction near critical point. We solve the unrestricted gap equation with a general d-wave symmetry gap and find that divergent magnetic correlation length $\xi$ leads to the very unharmonic shape of the gap function with shallow gap regions near nodes. These regions are extremely sensitive to disorder. Small impurity concentration induces substantial residual density of states. We argue that we can understand the large $N_{res}(0) = \lim_{T\to 0} C_p(T)/T$ value and its pressure dependence of the recently discovered $CeRhIn_5$ superconductor under pressure within this approach.Comment: 5 figure