A COMPARISON OF LOWER BODY ANGLES BETWEEN FREE HIGH PULLS AND A FIXED HIGH PULL APPARATUS

The majority of strength and conditioning programs for athletes are based on the Olympic lifting exercises. Olympic lifts generate explosive power through the lower body (Armstrong, 1993). There appears to be a relationship between resistance training exercises and bar path kinematics (Souza, Schimada, & Koontz, 2002). The resistance training program at the university used in this study had a piece of equipment called the Cormax ® Smith Machine Plus. The Cormax® Smith Machine Plus utilizes a barbell that is set in tracks which does not allow any horizontal bar movement. It also has a piston system that allows the athlete to throw and release the barbell. The pistons support the barbell and allows it to slowly drop back to the starting postion. The researchers were interested if the technique using this piece of equipment would be similar to the technique that is used with free weight high pulls. Therefore, the purpose of this study was to examine the lower body joint kinematics between the two methods of completing a high pull

ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervious system

Alternative polyadenylation (APA) has been implicated in a variety of developmental and disease processes. A particularly dramatic form of APA occurs in the developing nervous system of flies and mammals, whereby various developmental genes undergo coordinate 3' UTR extension. In Drosophila, the RNA-binding protein ELAV inhibits RNA processing at proximal polyadenylation sites, thereby fostering the formation of exceptionally long 3' UTRs. Here, we present evidence that paused Pol II promotes recruitment of ELAV to extended genes. Replacing promoters of extended genes with heterologous promoters blocks normal 3' extension in the nervous system, while extension-associated promoters can induce 3' extension in ectopic tissues expressing ELAV. Computational analyses suggest that promoter regions of extended genes tend to contain paused Pol II and associated cis-regulatory elements such as GAGA. ChIP-seq assays identify ELAV in the promoter regions of extended genes. Our study provides evidence for a regulatory link between promoter-proximal pausing and APA

Public crowdsourcing: Analyzing the role of government feedback on civic digital platforms

Government organizations increasingly use crowdsourcing platforms to interact with citizens and integrate their requests in designing and delivering public services. Drawing on attribution theory, this study asks how the causal attributions of the government response to a citizen request affect continued participation in crowdsourcing platforms. To test our hypotheses, we use a 7-year dataset of both online requests from citizens to government and government responses to citizen requests. We focus on citizen requests that are denied by government, and find that the reasoning for denying a request is related with continued participation behavior. Citizens are less willing to collaborate further with government via the platform, when their requests are denied although the locus of causality is with the government. This study contributes to research on the role of responsiveness in digital interaction between citizens and government and highlights the importance of rationale transparency to sustain citizen participation

A newly developed tool for intra-tracheal temperature and humidity assessment in laryngectomized individuals: the Airway Climate Explorer (ACE)

The aim of this study is to develop a postlaryngectomy airway climate explorer (ACE) for assessment of intratracheal temperature and humidity and of influence of heat and moisture exchangers (HMEs). Engineering goals were within-device condensation prevention and fast response time characteristics. The ACE consists of a small diameter, heated air-sampling catheter connected to a heated sensor house, containing a humidity sensor. Air is sucked through the catheter by a controlled-flow pump. Validation was performed in a climate chamber using a calibrated reference sensor and in a two-flow system. Additionally, the analyser was tested in vivo. Over the clinically relevant range of humidity values (5–42 mg H2O/l air) the sensor output highly correlates with the reference sensor readings (R2 > 0.99). The 1–1/e response times are all <0.5 s. A first in vivo pilot measurement was successful. The newly developed, verified, fast-responding ACE is suitable for postlaryngectomy airway climate assessment

Endotracheal temperature and humidity measurements in laryngectomized patients: intra- and inter-patient variability

This study assesses intra- and inter-patient variability in endotracheal climate (temperature and humidity) and effects of heat and moister exchangers (HME) in 16 laryngectomized individuals, measured repeatedly (N = 47). Inhalation Breath Length (IBL) was 1.35 s without HME and 1.05 s with HME (P < 0.0001). With HME, end-inspiratory (minimum) humidity values increased 5.8 mg H2O/L (P < 0.0001) and minimum temperature values decreased 1.6°C (P < 0.0001). For the temperature and humidity minimums, the inter-patient variability was much smaller than the short- and long-term intra-patient variability. For exhalation breath length and full breath length, the opposite was the case. Conclusions: (1) Because inter-patient variability is smaller than intra-patient variability, investigating endotracheal climate in a limited number of laryngectomized subjects is justified, provided repeated measurements per patient are accomplished; (2) main contributor to intra-patient variability is the positioning of the catheter tip in the trachea; (3) an HME leads to a shortened IBL which enhances the HME effect

The effect of a Heat and Moisture Exchanger (Provox® HME) on pulmonary protection after total laryngectomy: a randomized controlled study

The goal of this randomized controlled study was to investigate the effect of Heat and Moisture Exchanger use on pulmonary symptoms and quality of life aspects in laryngectomized patients. Eighty laryngectomized patients were included and randomized into an HME and Control group. The effect of the HME was evaluated by means of Tally Sheets and Structured Questionnaires. The results showed a significant decrease in the frequency of coughing, forced expectoration, and stoma cleaning in the HME group. There were trends for the prosthetic speakers to report more fluent speech with the HME and for the HME group to report fewer sleeping problems. In conclusion, this study, performed in Poland, confirms the results of previous studies performed in other countries, showing that pulmonary symptoms decrease significantly with HME use and that related aspects such as speech and sleeping tend to improve, regardless of country or climate

Повышение энергоэффективности Республики Марий Эл путем внедрения АСКУЭ

Plasma-treated polymers typically show changes of surface morphology as well as modifications in their chemical composition. Both effects are known to have an influence on deposition and adhesion of metal coatings, although the exact mechanisms are not yet understood. Besides high- energy electrons and chemically active species, the generated UV radiation is one major component of plasma surface modification. The energy of ultraviolet photons is sufficiently high to induce bond scissions in polymeric materials, which result in subsequent chemical reactions. In this study, excimer radiation from lasers (e.g. KrF, 248nm) or lamps (e.g. KrCI, 222nm) was used for the formation of polar functional groups on the surface. The treatment was carried out at atmospheric pressure, mostly in air. The chemical and physical properties of the irradiated surface are different compared with untreated areas. The resulting functional groups allow for a spontaneous deposition of molecular thin films from aqueous solutions. In particular, these can be complexes from noble metals. Noble metals catalyze deposition in electroless metallization baths. A process for selective metal deposition on polymers has been developed based on this principle. After deposition, the main issue is the adhesion that can be achieved in the polymer-metal interface. It is determined by chemical or physical interaction between the polymer surface and the adjacent layer, as well as by typographical features

Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney

Molecular cloning of xKSx, a novel rat gene expressed exclusively in the kidney.BackgroundWe aimed to identify genes with kidney specific, developmentally regulated expression. Here we report the cDNA sequence and expression pattern of KS, a novel kidney-specific rat gene.MethodsA partial cDNA was identified by differential display polymerase chain reaction (PCR) of a renal cell fraction enriched for proximal tubular and renin-expressing cells. Using the partial cDNA as a probe, a rat kidney cDNA library was screened. The full-length KS sequence was obtained by PCR amplification of cDNA ends. The expression pattern of KS was investigated by Northern blot. RNA was extracted from several organs of newborn and adult rats, as well as from the kidneys of rats with altered tubular function, that is, rats that had undergone unilateral nephrectomy, unilateral ureteral obstruction, neonatal losartan treatment, and the appropriate control animals. The expression of KS was also investigated in the kidneys of rats with spontaneous or renovascular hypertension.ResultsThe KS cDNA (2426bp) contained one open reading frame encoding a predicted 572 amino acid protein. The derived peptide sequence displayed approximately 70% similarity to the hypertension-related SA gene product and approximately 50% similarity to prokaryotic and eukaryotic acetyl-CoA synthases (EC 6.2.1.1). KS was expressed in the kidney and not in any other organ assayed. KS RNA was not detected in fetal and newborn rat kidney but became apparent after one week of postnatal life. Gene expression was downregulated in rat models of altered tubular function. KS expression was decreased in spontaneously hypertensive rats but not in renovascular hypertension.ConclusionKS, a novel rat gene, exhibits a unique tissue-specific expression exclusively in mature kidneys. The data suggest KS may encode an adenosine monophosphate binding enzyme