Experimental study of boundary layer transition on a heated flat plate

A detailed investigation to the document momentum and thermal development of boundary layers undergoing natural transition on a heated flat plate was performed. Experimental results of both overall and conditionally sampled characteristics of laminar, transitional, and low Reynolds number turbulent boundary layers are presented. Measurements were done in a low-speed, closed-loop wind tunnel with a freestream velocity of 100 ft/s and zero pressure gradient over a range of freestream turbulence intensities from 0.4 to 6 percent. The distributions of skin friction, heat transfer rate, and Reynolds shear stress were all consistent with previously published data. Reynolds analogy factors for momentum thickness Reynolds number, Re(sub theta) less than 2300 were found to be well predicted by laminar and turbulent correlations which accounted for an unheated starting length and uniform heat flux. A small dependence of turbulence results on the freestream turbulence intensity was observed

Some characteristics of bypass transition in a heated boundary layer

Experimental measurements of both mean and conditionally sampled characteristics of laminar, transitional and low Reynolds number turbulent boundary layers on a heated flat plate are presented. Measurements were obtained in air over a range of freestream turbulence intensities from 0.3 percent to 6 percent with a freestream velocity of 30.5 m/s and zero pressure gradient. Conditional sampling performed in the transitional boundary layers indicate the existence of a near-wall drop in intermittency, especially pronounced at low intermittencies. Nonturbulent intervals were observed to possess large levels of low-frequency unsteadiness, and turbulent intervals had peak intensities as much as 50 percent higher than were measured at fully turbulent stations. Heat transfer results were consistent with results of previous researchers and Reynolds analogy factors were found to be well predicted by laminar and turbulent correlations which accounted for unheated starting length. A small dependence of the turbulent Reynolds analogy factors on freestream turbulence level was observed. Laminar boundary layer spectra indicated selective amplification of unstable frequencies. These instabilities appear to play a dominant role in the transition process only for the lowest freestream turbulence level studied, however

Turbulent heat flux measurements in a transitional boundary layer

During an experimental investigation of the transitional boundary layer over a heated flat plate, an unexpected result was encountered for the turbulent heat flux (bar-v't'). This quantity, representing the correlation between the fluctuating normal velocity and the temperature, was measured to be negative near the wall under certain conditions. The result was unexpected as it implied a counter-gradient heat transfer by the turbulent fluctuations. Possible reasons for this anomalous result were further investigated. The possible causes considered for this negative bar-v't' were: (1) plausible measurement error and peculiarity of the flow facility, (2) large probe size effect, (3) 'streaky structure' in the near wall boundary layer, and (4) contributions from other terms usually assumed negligible in the energy equation including the Reynolds heat flux in the streamwise direction (bar-u't'). Even though the energy balance has remained inconclusive, none of the items (1) to (3) appear to be contributing directly to the anomaly

Bisphosphonate inhibits the expression of cyclin A2 at the transcriptional level in normal human oral keratinocytes.

Nitrogen-containing bisphosphonates (N-BPs) are the most widely used anti-resorptive agents in the treatment of bone-related diseases. N-BPs inhibit bone resorption by specifically targeting osteoclasts, bone-resorbing cells. However, soft tissue toxicity, such as oral or gastrointestinal (GI) ulcerations has frequently been reported in N-BP users, suggesting that N-BPs may also directly target cells other than osteoclasts. Previously, we reported that BPs inhibit proliferation without inducing the apoptosis of normal human oral keratinocytes (NHOKs). However, the molecular mechanisms through which N-BPs inhibit the proliferation of NHOKs are not yet fully understood. In this study, we performed gene expression profiling in N-BP-treated NHOKs and identified cyclin A2 as one of the most commonly downregulated genes. When the NHOKs were treated with N-BPs, we found that the level of cyclin A2 was suppressed in a dose- and time-dependent manner. In addition, the protein level of cyclin A2 was also significantly lower in oral epithelial cells in N-BP-treated oral mucosal tissue constructs. Cyclin A2 promoter reporter assay revealed that N-BPs inhibited the luciferase activity, indicating that the inhibition of cyclin A2 expression occurs at the transcriptional level. Furthermore, N-BPs did not alter the expression of cyclin A2 in normal human oral fibroblasts (NHOFs), suggesting that the effect of N-BPs on cyclin A2 expression may be cell-type specific. Thus, the findings of our study demonstrate that the inhibition of NHOK proliferation by N-BPs is mediated, at least in part, by the suppression of cyclin A2 expression at the transcriptional level, which may explain the underlying mechanisms of soft tissue toxicity by N-BPs

Giant Shapiro Resonances in a Flux Driven Josephson Junction Necklace

We present a detailed study of the dynamic response of a ring of $N$ equally spaced Josephson junctions to a time-periodic external flux, including screening current effects. The dynamics are described by the resistively shunted Josephson junction model, appropriate for proximity effect junctions, and we include Faraday's law for the flux. We find that the time-averaged $I-V$ characteristics show novel {\em subharmonic giant Shapiro voltage resonances}, which strongly depend on having phase slips or not, on $N$, on the inductance and on the external drive frequency. We include an estimate of the possible experimental parameters needed to observe these quantized voltage spikes.Comment: 8 pages RevTeX, 3 figures available upon reques

The effects of smoking on obesity: Evidence from Indonesian panel data

Background: It has been known that smoking is negatively related to weight-related outcomes. However, it has been difficult to determine whether the relationship is causal, and if so, how strong it is. We attempted to estimate the approximately causal effects of smoking on weight, body mass index (BMI), and obesity. Methods: The Indonesian Family Life Survey provided a sample of over 9000 men aged 15-55 years - each of them was observed in 1993, 1997, 2000 and 2007. The preferred method was a fixed effects model; that is, we related changes in smoking status or smoking intensity to changes in weight-related outcomes, while controlling for time-varying covariates. We also compared these results to those estimated by ordinary least squares and assessed the importance of controlling for time invariant individual heterogeneity. Results: Although the effects of smoking were precisely estimated in a statistical sense, their size was minuscule: a quitter would gain weight by at most 1 kg, or a smoker would lose weight by the same amount. The results were similar for BMI and obesity. When we did not control for time invariant individual heterogeneity, the size of the relationship was overestimated at least three times. Conclusions: Smoking exerted little influence on weight, and it was important to control for bias stemming from time invariant individual heterogeneity

Advanced Ultrasonic Structural Monitoring of Waveguides

Ultrasonic Guided Waves (UGWs) are a useful tool in those structural health monitoring applications that can benefit from built-in transduction, moderately large inspection ranges and high sensitivity to small flaws. This paper describes two methods, based on linear and nonlinear acoustics for structural damage detection based on UGWs. The linear method combine the advantages of UGW inspection with the outcomes of the Discrete Wavelet Transform (DWT) that is used for extracting defect-sensitive features that can be combined to perform a multivariate diagnosis of damage. In particular, the DWT is exploited to generate a set of relevant wavelet coefficients to construct a uni-dimensional or multi-dimensional damage index that, in turn is fed to an outlier algorithm to detect anomalous structural states. The nonlinear acoustics method exploits the circumstance that a cracked medium exhibits high acoustic nonlinearity which is manifested as harmonics in the power spectrum of the received signal. Experimental results also indicate that the harmonic components increase non-linearly in magnitude with increasing amplitude of the input signal. The proposed nonlinear technique identifies the presence of cracks by looking at the harmonics and their nonlinear relationship to the input amplitude. The general framework presented in this paper is applied to the detection of fatigue cracks in an I-shaped steel beam. The probing hardware consists of Lead Zirconate Titanate (PZT) materials used for both ultrasound generation and detection at chosen frequency. The effectiveness of the proposed methods for the structural diagnosis of defects that are small compared to the waveguide cross-sectional area is discussed

Ballistic dynamics of a convex smooth-wall billiard with finite escape rate along the boundary

We focus on the problem of an impurity-free billiard with a random position-dependent boundary coupling to the environment. The response functions of such an open system can be obtained non-perturbatively from a supersymmetric generating functional. The derivation of this functional is based on averaging over the escape rates and results in a non-linear ballistic $\sigma$-model, characterized by system-specific parameters. Particular emphasis is placed on the {}``whispering gallery modes'' as the origin of surface diffusion modes in the limit of large dimensionless conductance.Comment: 12 pages, no figure

Damage and repair classification in reinforced concrete beams using frequency domain data

This research aims at developing a new vibration-based damage classification technique that can efficiently be applied to a real-time large data. Statistical pattern recognition paradigm is relevant to perform a reliable site-location damage diagnosis system. By adopting such paradigm, the finite element and other inverse models with their intensive computations, corrections and inherent inaccuracies can be avoided. In this research, a two-stage combination between principal component analysis and Karhunen-Loéve transformation (also known as canonical correlation analysis) was proposed as a statistical-based damage classification technique. Vibration measurements from frequency domain were tested as possible damage-sensitive features. The performance of the proposed system was tested and verified on real vibration measurements collected from five laboratory-scale reinforced concrete beams modelled with various ranges of defects. The results of the system helped in distinguishing between normal and damaged patterns in structural vibration data. Most importantly, the system further dissected reasonably each main damage group into subgroups according to their severity of damage. Its efficiency was conclusively proved on data from both frequency response functions and response-only functions. The outcomes of this two-stage system showed a realistic detection and classification and outperform results from the principal component analysis-only. The success of this classification model is substantially tenable because the observed clusters come from well-controlled and known state conditions