288 research outputs found
Regulation of plant development and defense response by fireman, a new small endogenous peptide
Observation of anomalous spin-state segregation in a trapped ultra-cold vapor
We observe counter-intuitive spin segregation in an inhomogeneous sample of
ultra-cold, non-condensed Rubidium atoms in a magnetic trap. We use spatially
selective microwave spectroscopy to verify a model that accounts for the
differential forces on two internal spin states. In any simple understanding of
the cloud dynamics, the forces are far too small to account for the dramatic
transient spin polarizations observed. The underlying mechanism remains to be
elucidated.Comment: 5 pages, 3 figure
Internal state conversion in ultracold gases
We consider an ultracold gas of (non-condensed) bosons or fermions with two
internal states, and study the effect of a gradient of the transition frequency
between these states. When a RF pulse is applied to the sample,
exchange effects during collisions transfer the atoms into internal states
which depend on the direction of their velocity. This results, after a short
time, in a spatial separation between the two states. A kinetic equation is
solved analytically and numerically; the results agree well with the recent
observations of Lewandowski et al.Comment: Accepted version, to appear in PR
Calculation of NMR Properties of Solitons in Superfluid 3He-A
Superfluid 3He-A has domain-wall-like structures, which are called solitons.
We calculate numerically the structure of a splay soliton. We study the effect
of solitons on the nuclear-magnetic-resonance spectrum by calculating the
frequency shifts and the amplitudes of the soliton peaks for both longitudinal
and transverse oscillations of magnetization. The effect of dissipation caused
by normal-superfluid conversion and spin diffusion is calculated. The
calculations are in good agreement with experiments, except a problem in the
transverse resonance frequency of the splay soliton or in magnetic-field
dependence of reduced resonance frequencies.Comment: 15 pages, 10 figures, updated to the published versio
On dynamic network entropy in cancer
The cellular phenotype is described by a complex network of molecular
interactions. Elucidating network properties that distinguish disease from the
healthy cellular state is therefore of critical importance for gaining
systems-level insights into disease mechanisms and ultimately for developing
improved therapies. By integrating gene expression data with a protein
interaction network to induce a stochastic dynamics on the network, we here
demonstrate that cancer cells are characterised by an increase in the dynamic
network entropy, compared to cells of normal physiology. Using a fundamental
relation between the macroscopic resilience of a dynamical system and the
uncertainty (entropy) in the underlying microscopic processes, we argue that
cancer cells will be more robust to random gene perturbations. In addition, we
formally demonstrate that gene expression differences between normal and cancer
tissue are anticorrelated with local dynamic entropy changes, thus providing a
systemic link between gene expression changes at the nodes and their local
network dynamics. In particular, we also find that genes which drive
cell-proliferation in cancer cells and which often encode oncogenes are
associated with reductions in the dynamic network entropy. In summary, our
results support the view that the observed increased robustness of cancer cells
to perturbation and therapy may be due to an increase in the dynamic network
entropy that allows cells to adapt to the new cellular stresses. Conversely,
genes that exhibit local flux entropy decreases in cancer may render cancer
cells more susceptible to targeted intervention and may therefore represent
promising drug targets.Comment: 10 pages, 3 figures, 4 tables. Submitte
Optical Confinement of a Bose-Einstein Condensate
Bose-Einstein condensates of sodium atoms have been confined in an optical
dipole trap using a single focused infrared laser beam. This eliminates the
restrictions of magnetic traps for further studies of atom lasers and
Bose-Einstein condensates. More than five million condensed atoms were
transferred into the optical trap. Densities of up to of Bose condensed atoms were obtained, allowing for a measurement of
the three-body decay rate constant for sodium condensates as . At lower densities, the observed 1/e
lifetime was more than 10 sec. Simultaneous confinement of Bose-Einstein
condensates in several hyperfine states was demonstrated.Comment: 5 pages, 4 figure
Text mining for the biocuration workflow
Molecular biology has become heavily dependent on biological knowledge encoded in expert curated biological databases. As the volume of biological literature increases, biocurators need help in keeping up with the literature; (semi-) automated aids for biocuration would seem to be an ideal application for natural language processing and text mining. However, to date, there have been few documented successes for improving biocuration throughput using text mining. Our initial investigations took place for the workshop on ‘Text Mining for the BioCuration Workflow’ at the third International Biocuration Conference (Berlin, 2009). We interviewed biocurators to obtain workflows from eight biological databases. This initial study revealed high-level commonalities, including (i) selection of documents for curation; (ii) indexing of documents with biologically relevant entities (e.g. genes); and (iii) detailed curation of specific relations (e.g. interactions); however, the detailed workflows also showed many variabilities. Following the workshop, we conducted a survey of biocurators. The survey identified biocurator priorities, including the handling of full text indexed with biological entities and support for the identification and prioritization of documents for curation. It also indicated that two-thirds of the biocuration teams had experimented with text mining and almost half were using text mining at that time. Analysis of our interviews and survey provide a set of requirements for the integration of text mining into the biocuration workflow. These can guide the identification of common needs across curated databases and encourage joint experimentation involving biocurators, text mining developers and the larger biomedical research community
Forecast for HEAT on Dome A, Antarctica: the High Elevation Antarctic Terahertz Telescope
We have proposed to develop a prototype 0.5-meter far-infrared telescope and heterodyne receiver/spectrometer system for fully-automated remote operation at the summit of Dome A, the highest point on the Antarctic plateau. The unparalleled stability, exceptional dryness, low wind and extreme cold make Dome A a ground-based site without equal for astronomy at infrared and submillimeter wavelengths. HEAT, the High Elevation Antarctic Terahertz Telescope, will operate in the atmospheric windows between 150 and 400 microns, in which the most crucial astrophysical spectral diagnostics of the formation of galaxies, stars, planets, and life are found. At these wavelengths, HEAT will have high aperture efficiency and excellent atmospheric transmission most of the year. The proposed superheterodyne receiver system will be comprised of 0.8, 1.4 and 1.9 THz channels which will observe the pivotal J=7-6 line of CO, the J=2-1 line of atomic carbon, and the far-infrared fine structure lines of N+ and C+, the brightest emission lines in the entire Milky Way Galaxy. When combined with the HEAT telescope, the receiver system represents a uniquely powerful instrument for reconstructing the history of star formation in our Galaxy, with application to the distant Universe. The receiver system itself serves as a valuable testbed for heterodyne Terahertz components, using leading-edge mixer, local oscillator, low-noise amplifier, cryogenic, and digital signal processing technologies that will play essential roles in future Terahertz observatories. The proposed study will pave the way for future astronomical investigations from Dome A
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