Human complement factor H

We isolated cDNA clones coding for the functionally important tryptic N-terminal38- kDa fragment of human complement control protein factor H using polyclonal and monoclonal antibodies to screen a human liver cDNA library cloned in a bacterial expression vector, PEX-1. By testing the reactivity of antibodies specific for the recombinant proteins produced by individual clones with proteolytic fragments of serum H the exact position of these cDNA clones within H was mapped. One clone, H-19, coding for the 38-kDa fragment of H was sequenced and found to code for 289 amino acids derived from the 38-kDa N-terminal fragment as well as for the first 108 amino acids belonging to the complementary 142-kDa tryptic fragment. The derived protein sequence could be arranged in 6 highly homologous repeats of about 60 amino acids each, the homology between the repeats being determined by the characteristic position of cysteine, proline, glycine, tyrosine and tryptophane residues. The region coding for the epitope recognized by one of our monoclonal antibodies was localized by subcloning restriction fragments of H-19 into the expression plasmid and testing for the expression of this epitope

A Generalized Preferential Attachment Model for Business Firms Growth Rates: II. Mathematical Treatment

We present a preferential attachment growth model to obtain the distribution $P(K)$ of number of units $K$ in the classes which may represent business firms or other socio-economic entities. We found that $P(K)$ is described in its central part by a power law with an exponent $\phi=2+b/(1-b)$ which depends on the probability of entry of new classes, $b$. In a particular problem of city population this distribution is equivalent to the well known Zipf law. In the absence of the new classes entry, the distribution $P(K)$ is exponential. Using analytical form of $P(K)$ and assuming proportional growth for units, we derive $P(g)$, the distribution of business firm growth rates. The model predicts that $P(g)$ has a Laplacian cusp in the central part and asymptotic power-law tails with an exponent $\zeta=3$. We test the analytical expressions derived using heuristic arguments by simulations. The model might also explain the size-variance relationship of the firm growth rates.Comment: 19 pages 6 figures Applications of Physics in Financial Analysis, APFA

Potential model calculations and predictions for heavy quarkonium

We investigate the spectroscopy and decays of the charmonium and upsilon systems in a potential model consisting of a relativistic kinetic energy term, a linear confining term including its scalar and vector relativistic corrections and the complete perturbative one-loop quantum chromodynamic short distance potential. The masses and wave functions of the various states are obtained using a variational technique, which allows us to compare the results for both perturbative and nonperturbative treatments of the potential. As well as comparing the mass spectra, radiative widths and leptonic widths with the available data, we include a discussion of the errors on the parameters contained in the potential, the effect of mixing on the leptonic widths, the Lorentz nature of the confining potential and the possible $c\bar{c}$ interpretation of recently discovered charmonium-like states.Comment: Physical Review published versio

Exploring the environment, magnetic fields, and feedback effects of massive high-redshift galaxies with [CII]

Massive galaxies are expected to grow through different transformative evolutionary phases where high-redshift starburst galaxies and quasars are examples of such phases. The physical mechanisms driving these phases include companion galaxy interactions, active galactic nuclei feedback, and magnetic fields. Our aim is to characterize the physical properties and the environment of the submillimeter galaxy AzTEC-3 at z = 5.3 and the lensed quasar BRI 0952-0115 at z = 4.4, to set a limit on the polarization properties, as well as placing both in the broader context of galaxy evolution. We used full polarization, sub-arcsecond-resolution, ALMA band-7 observations of both BRI 0952-0115 and AzTEC-3 and detect [CII] line emission towards both galaxies, along with companions in each field. We present an updated gravitational lensing model for BRI 0952-0115. We present infrared luminosities, star-formation rates, and [CII] line to infrared luminosity ratios for each source. The [CII] emission line profile for both BRI 0952-0115 and AzTEC-3 exhibit a broad, complex morphology, indicating the possible presence of outflows. We present evidence of a 'gas bridge' between AzTEC-3 and a companion source. Using a simple dynamical mass estimate for the sources, we suggest that both systems are undergoing minor or major mergers. No polarization is detected for the [CII], placing an upper limit below that of theoretical predictions. Our results show that high-velocity wings are detected, indicating possible signs of massive outflows; however, the presence of companion galaxies can affect the final interpretation. Furthermore, the results provide additional evidence in support of the hypothesis that massive galaxies form in overdense regions, growing through interactions. Finally, strong, ordered magnetic fields are unlikely to exist at the kiloparsec scale in the two studied sources

RESONANT STRUCTURE IN THE KUIPER DISK: AN ASYMMETRIC PLUTINO DISK

In order to develop a dynamical model of the Kuiper disk, we run numerical integrations of particles originating from source bodies trapped in the 3 : 2 external mean motion resonance with Neptune to determine what percentage of particles remain in the resonance for a variety of particle and source body sizes. The dynamical evolution of the particles is followed from source to sink with Poynting-Robertson light drag, solar wind drag, radiation pressure, the Lorentz force, neutral interstellar gas drag, and the effects of planetary gravitational perturbations included. We find that the number of particles in the 3 : 2 resonance increases with decreasing � (i.e., increasing particle size) for the cases in which the initial source bodies are small (� 10 km in diameter) and that the percentage of particles in resonance is not significantly changed by either the addition of the Lorentz force, as long as the potential of the particles is small (� 5 V), or the effect of neutral interstellar gas drag. The brightness of the entire Kuiper disk is calculated using a model composed of 500 lm diameter particles and fits well with upper limits to the Kuiper disk brightness and previous estimates. A disk with a size-frequency distribution weighted toward large particles, which are more likely to remain in resonance, may have a stronger, more easily identifiable resonant signature than a disk composed of small particles

Self-aligned 0.12mm T-gate In.53Ga.47As/In.52Al.48As HEMT Technology Utilising a Non Annealed Ohmic Contact Strategy

An InGaAs/InAlAs based HEMT structure, lattice matched to an InP substrate, is presented in which drive current and transconductance has been optimized through a double-delta doping strategy. Together with an increase in channel carrier density, this allows the use of a non-annealed ohmic contact process. HEMT devices with 120 nm standard and self-aligned T-gates were fabricated using the non-annealed ohmic process. At DC, self-aligned and standard devices exhibited transconductances of up to 1480 and 1100 mS/mm respectively, while both demonstrated current densities in the range 800 mA/mm. At RF, a cutoff frequency f/sub T/ of 190 GHz was extracted for the self-aligned device. The DC characteristics of the standard devices were then calibrated and modelled using a compound semiconductor Monte Carlo device simulator. MC simulations provide insight into transport within the channel and illustrate benefits over a single delta doped structure