Social Context, Sexual Strategies, and Risks for HIV Transmission among Men who have Sex with Men: The South Beach Health Survey

In a population-based sample of 193 men who had sex with men in South Beach, Miami-Dade County, Florida, two indicators of social context—choice of sexual relationships and perceived HIV-infection status—were used to analyze residents who engaged in certain sexual practices with their partners. The vast majority (88.6%) of respondents reported engagement in anal sex during the previous 12 months; 20.2% reported unprotected anal intercourse (UAI) with ejaculation with any partner and 12.4% reported UAI with ejaculation with one or more casual partners. Findings supported the hypothesis that primary partner relationships and perceived HIV status are important variables for understanding engagement in UAI with ejaculation. Men who engaged in such behaviors with casual partners were more likely to have negative attitudes towards condoms, report difficulty communicating desires for safer sex, disagree with the belief that AIDS is fatal, and be intoxicated during anal intercourse. Men who reported engaging in anal intercourse, but who never shared unprotected ejaculations, were most likely to be unknowingly infected with HIV, suggesting that many men may become infected while following what they believe to be “safer sex practices.” In designing effective interventions, public health authorities need to take into account socially embedded risk-negotiating practices

Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells.

Tumor cells harboring stem-like/cancer stem cell (CSC) properties have been identified and isolated from numerous hematological and solid malignancies. These stem-like tumor cells can persist following conventional cytoreductive therapies, such as chemotherapy and radiotherapy, thereby repopulating the tumor and seeding relapse and/or metastasis. We have previously shown that natural killer (NK) cells preferentially target stem-like tumor cells via non- major histocompatibility complex (MHC) restricted mechanisms. Here, we demonstrated that the proteasome inhibitor, bortezomib, augments NK cell targeting of stem cell-like tumor cells against multiple solid human tumor-derived cancer lines and primary tissue samples. Mechanistically, this was mediated by the upregulation of cell surface NK ligands MHC class I chain-related protein A and B (MICA and MICB) on aldehyde dehydrogenases (ALDH)-positive CSCs. The increased expression of MICA and MICB on CSC targets thereby enhanced NK cell mediated killing in vitro and ex vivo from both human primary tumor and patient-derived xenograft samples. In vivo, the combination of bortezomib and allogeneic NK cell adoptive transfer in immunodeficient mice led to increased elimination of CSCs as well as tumor growth delay of orthotopic glioblastoma tumors. Taken together, our data support the combination bortezomib and NK transfer as a strategy for both CSC targeting and potentially improved outcomes in clinical cancer patients

Solid State Neutral Particle Analyzer Array on NSTX

A Solid State Neutral Particle Analyzer (SSNPA) array has been installed on the National Spherical Torus Experiment (NSTX). The array consists of four chords viewing through a common vacuum flange. The tangency radii of the viewing chords are 60, 90, 100, and 120 cm. They view across the three co-injection neutral beam lines (deuterium, 80 keV (typ.) with tangency radii 48.7, 59.2, and 69.4 cm) on NSTX and detect co-going energetic ions. A silicon photodiode used was calibrated by using a mono-energetic deuteron beam source. Deuterons with energy above 40 keV can be detected with the present setup. The degradation of the performance was also investigated. Lead shots and epoxy are used for neutron shielding to reduce handling any hazardous heavy metal. This method also enables us to make an arbitrary shape to be fit into the complex flight tube

Limitations of Counseling and Testing in CDC\u27s HIV Prevention Efforts

To the Editor: We were delighted to see that our colleagues at the Centers for Disease Control and Prevention (CDC) had read our article (Darrow et al., 1998a) and responded (Wolitski and Doll, 1999). Their criticisms of our cross-sectional study of 51 HIV-infected men who have sex with men (MSM) and live in South Beach are welcomed and appreciated. In this brief reply, we continue the dialogue by addressing their concerns and recommending an appropriate course of action

Diagnosis and Management of Infantile Hemangioma

Infantile hemangiomas (IHs) are the most common tumors of childhood. Unlike other tumors, they have the unique ability to involute after proliferation, often leading primary care providers to assume they will resolve without intervention or consequence. Unfortunately, a subset of IHs rapidly develop complications, resulting in pain, functional impairment, or permanent disfigurement. As a result, the primary clinician has the task of determining which lesions require early consultation with a specialist. Although several recent reviews have been published, this clinical report is the first based on input from individuals representing the many specialties involved in the treatment of IH. Its purpose is to update the pediatric community regarding recent discoveries in IH pathogenesis, treatment, and clinical associations and to provide a basis for clinical decision-making in the management of IH

Design and initial operation of lost fast-ion probe based on thin Faraday films in CHS

The purpose of this work is to measure lost fast ions as an ion current so as to make quantitative argument on flux of fast-ion loss possible. We have designed and constructed a lost fast-ion probe based on combination of thin Faraday films and small rectangular apertures, called FLIP, for the Compact Helical System. The current generated by escaping fast ions has been successfully measured with the FLIP in neutral-beam-heated plasmas. The FLIP detected increased flux of escaping fast ions while fast-ion-driven magnetohydrodynamics instabilities appear