1,438 research outputs found
Temporally Coherent Backmapping of Molecular Trajectories From Coarse-Grained to Atomistic Resolution
Probably Safe or Live
This paper presents a formal characterisation of safety and liveness
properties \`a la Alpern and Schneider for fully probabilistic systems. As for
the classical setting, it is established that any (probabilistic tree) property
is equivalent to a conjunction of a safety and liveness property. A simple
algorithm is provided to obtain such property decomposition for flat
probabilistic CTL (PCTL). A safe fragment of PCTL is identified that provides a
sound and complete characterisation of safety properties. For liveness
properties, we provide two PCTL fragments, a sound and a complete one. We show
that safety properties only have finite counterexamples, whereas liveness
properties have none. We compare our characterisation for qualitative
properties with the one for branching time properties by Manolios and Trefler,
and present sound and complete PCTL fragments for characterising the notions of
strong safety and absolute liveness coined by Sistla
89 Superior effects of RV568, a narrow spectrum kinase inhibitor, on RSV infection in primary bronchial epithelial cells obtained from patients with cystic fibrosis
Laser induced electron diffraction: a tool for molecular orbital imaging
We explore the laser-induced ionization dynamics of N2 and CO2 molecules
subjected to a few-cycle, linearly polarized, 800\,nm laser pulse using
effective two-dimensional single active electron time-dependent quantum
simulations. We show that the electron recollision process taking place after
an initial tunnel ionization stage results in quantum interference patterns in
the energy resolved photo-electron signals. If the molecule is initially
aligned perpendicular to the field polarization, the position and relative
heights of the associated fringes can be related to the molecular geometrical
and orbital structure, using a simple inversion algorithm which takes into
account the symmetry of the initial molecular orbital from which the ionized
electron is produced. We show that it is possible to extract inter-atomic
distances in the molecule from an averaged photon-electron signal with an
accuracy of a few percents
Two-Color Coherent Photodissociation of Nitrogen Oxide in Intense Laser Fields
A simple one-dimensional semi-classical model with a Morse potential is used
to investigate the possibility of two-color infrared multi-photon dissociation
of vibrationally excited nitrogen oxide. The amplitude ratio effects and
adiabatic effects are investigated. Some initial states are found to have
thresholds smaller than expected from single-mode considerations and multiple
thresholds exist for initial states up to 32.
PACS: 42.50.HzComment: 3 pages, old papers, add source files to replace original postscrip
Coherent Control of Isotope Separation in HD+ Photodissociation by Strong Fields
The photodissociation of the HD+ molecular ion in intense short- pulsed
linearly polarized laser fields is studied using a time- dependent wave-packet
approach where molecular rotation is fully included. We show that applying a
coherent superposition of the fundamental radiation with its second harmonic
can lead to asymmetries in the fragment angular distributions, with significant
differences between the hydrogen and deuterium distributions in the long
wavelength domain where the permanent dipole is most efficient. This effect is
used to induce an appreciable isotope separation.Comment: Physical Review Letters, 1995 (in press). 4 pages in revtex format, 3
uuencoded figures. Full postcript version available at:
http://chemphys.weizmann.ac.il/~charron/prl.ps or
ftp://scipion.ppm.u-psud.fr/coherent.control/prl.p
Monitoring Partially Synchronous Distributed Systems using SMT Solvers
In this paper, we discuss the feasibility of monitoring partially synchronous
distributed systems to detect latent bugs, i.e., errors caused by concurrency
and race conditions among concurrent processes. We present a monitoring
framework where we model both system constraints and latent bugs as
Satisfiability Modulo Theories (SMT) formulas, and we detect the presence of
latent bugs using an SMT solver. We demonstrate the feasibility of our
framework using both synthetic applications where latent bugs occur at any time
with random probability and an application involving exclusive access to a
shared resource with a subtle timing bug. We illustrate how the time required
for verification is affected by parameters such as communication frequency,
latency, and clock skew. Our results show that our framework can be used for
real-life applications, and because our framework uses SMT solvers, the range
of appropriate applications will increase as these solvers become more
efficient over time.Comment: Technical Report corresponding to the paper accepted at Runtime
Verification (RV) 201
Widely distributed breeding populations of Canada warbler (Cardellina canadensis) converge on migration through Central America
Background
To effectively conserve migratory species, the entire range encompassed by their annual life cycle needs to be considered. Most research on Nearctic-Neotropical migratory birds has focused on the breeding grounds resulting in a general lack of knowledge regarding the wintering and migratory periods. The Canada Warbler (Cardellina canadensis) has declined by 71% from 1970 to 2012, at a rate of 2.9% per year, and is listed as Threatened in Canada. As with most Nearctic-Neotropical migrants, conservation efforts outside the breeding range are limited by a poor understanding of migration routes and the connectivity between specific breeding and wintering populations.
Results
To determine migratory routes of multiple breeding populations of Canada Warblers, we directly-tracked individuals using light-level geolocators deployed at four sites across the breeding range, spanning approximately 43 degrees in longitude (Alberta, Manitoba and QuĂ©bec, Canada, and New Hampshire, USA). Twenty-five geolocators with usable data were recovered from three sites and were analyzed using FlightR to determine fall migration routes (nâ=â18) and individual wintering sites (nâ=â25). Individuals from all breeding populations took a western fall migration route at the Gulf of Mexico; with 77.8% of birds funnelling into a narrow geographic space along the western side of the Gulf of Mexico (97°W-99°W). We found no evidence for population-specific, parallel migration routes. Most individuals (72%) overwintered in Colombia. The remaining individuals overwintered in Venezuela.
Conclusions
Our results demonstrate convergence of migratory routes around a migration barrier for individuals originating from widely distributed breeding areas. Further, we suggest the potential importance of habitat around the Gulf of Mexico during migration and Andean forest in Colombia as overwintering habitat for this threatened species. Future research should be directed at understanding how these areas are used by Canada Warblers
In utero exposure to a maternal high-fat diet alters the epigenetic histone code in a murine model
OBJECTIVE: Data from animal models show that in utero exposure to a maternal high-fat diet (HFD) renders susceptibility of these offspring to the adult onset of metabolic syndrome. We and others have previously shown that epigenetic modifications to histones may serve as a molecular memory of the in utero exposure, rendering the risk of adult disease. Because mice heterozygous for the Glut4 gene (insulin sensitive glucose transporter) born to wild-type (WT) mothers demonstrate exacterbated metabolic syndrome when exposed to an HFD in utero, we sought to analyze the genome-wide epigenetic changes that occur in the fetal liver in susceptible offspring. STUDY DESIGN: WT and Glut4(+/-) (G4(+/-)) offspring of WT mothers that were exposed either to a control or an HFD in utero were studied. Immunoblotting was used to measure hepatic histone modifications of fetal and 5-week animals. Chromatin immunoprecipitation (ChIP) followed by hybridization to chip arrays (ChIP-on-chip) was used to detect genome-wide changes of histone modifications with HFD exposure. RESULTS: We found that levels of hepatic H3K14ac and H3K9me3 significantly increased with HFD exposure in WT and G4(+/-) fetal and 5-week offspring. Pathway analysis of our ChIP-on-chip data revealed differential H3K14ac and H3K9me3 enrichment along pathways that regulate lipid metabolism, specifically in the promoter regions of Pparg, Ppara, Rxra, and Rora. CONCLUSION: We conclude that HFD exposure in utero is associated with functional alterations to fetal hepatic histone modifications in both WT and G4(+/-) offspring, some of which persist up to 5 weeks of age
Impact of a Preconception Counseling Program for Teens With Type 1 Diabetes (READY-Girls) on Patient-Provider Interaction, Resource Utilization, and Cost
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