Adopting a Reference Standard Port for Nigeria

Nigeria has a coastline of about 800km which is covered by only two Standard ports located at Bonny in Nigeria and Takoradi in Ghana. Tidal analyses were carried out to verify the rational in referencing some secondary port in Nigeria to the standard port in Ghana. Result showed that, for all locations in Nigeria, analysis made with reference to Bonny gives either better or similar accuracy when compared with analysis made with reference to Takoradi. It is therefore concluded that, depending on the availability of the needed tidal data, referred to Bonny, the use of Takoradi as the reference port for some locations in Nigeria may not be necessary.Nigeria tiene una linea de costa de cerca de 800km que esta cubierta por solo dos puertos principales ubicados en Bonny, Nigeria y Takoradi en Ghana. Se llevaron a cabo anâlisis de la marea para verificar la relaciôn referendaI de algunos puertos secundarios en Nigeria respecto del puerto principal en Ghana. Los resultados mostraron que, para todas las localidades en Nigeria, los anâlisis hecho con referenda a Bonny entregan ya sea una mejor o similar precision cuando se comparan con los anâlisis hechos c on referenda a Takoradi. Por lo tanto se concluye en que, dependiendo de la disponibilidad de los necesarios datos de marea, referidos a Bonny, el uso de Takoradi como puerto de referenda puede no ser necesario para ciertas localidades en Nigeria.Le Nigéria possède une ligne de côte d’environ 800km qui est seulement couverte par deux ports principaux situés à Bonny au Nigéria et Takoradi au Ghana. Des analyses de marée ont été menées pour justifier les relations référentielles de certains ports secondaires au Nigéria par rapport au port principal au Ghana. Les résultats ont montré que, pour l’ensemble des lieux situés au Nigéria, l'analyse conduite en référence à Bonny donne une précision meilleure ou similaire comparée à l’analyse fait en référence à Takoradi. il est en conséquence conclu que, selon la disponibilité des données de marée nécessaires, l’utilisation de Takoradi comme port de référence pour certains lieux au Nigéria pourrait ne pas être nécessaire

Hybrid clear cell odontogenic carcinoma and ameloblastic carcinoma-report of a case

Ameloblastic carcinoma (AC) produces extensive local destruction, perforation of the cortical plate, extension into surrounding soft tissues, numerous recurrent lesions, and metastasis, usually to cervical lymph nodes. Clear cell odontogenic carcinoma (CCOC) which was previously designated clear cell odontogenic tumor also exhibits an aggressive biologic behavior and a tendency to metastasize to distant locations. Both lesions are rare. We report an odontogenic carcinoma with a dual histomorphologic feature of CCOC and AC coexisting in a single lesion. To the best of our knowledge, this is the first report of its kind in the literature

Rapid and safe ASAP acquisition with EXACT NMR

EXACT acquisition allows the fast and safer acquisition of ASAP 2D NMR experiments in just a few seconds.</p

Succinylation of potato (Ipomoea batatas) starch: effect of varying ethanol concentration on pasting, structural, morphological, and functional properties

The shortcomings arising from usage of native starches in various industrial processes have demanded the need for modification in order to enhance its functionality. This study investigated the impact of ethanol concentration on pasting, structural, morphological, and functional properties of succinylated potato starch. Some granules of the potato starch sample also appeared to be multilobed and fractured. The Fourier transform -1 infrared spectroscopy (FT-IR) study revealed the presence of carbonyl group (1747 cm-1 ) in the starch chains as an additional functional group after succinylation. The statistical analysis of the study data revealed a significant (p &lt; 0.05) decrease in protein, fat, fibre, ash, and reduction in moisture contents after modification. Analysis with visco-analyzer showed reduction in pasting parameters after modification. Modification of native potato starch with ethanol improved the functionality of the starch by imparting some additional physicochemical and functional properties. These improved properties upon modification, therefore, suggest some potential favorable qualities for special applications

Ethical and practical considerations for HIV cure-related research at the end-of-life: a qualitative interview and focus group study in the United States

Background: One of the next frontiers in HIV research is focused on finding a cure. A new priority includes people with HIV (PWH) with non-AIDS terminal illnesses who are willing to donate their bodies at the end-of-life (EOL) to advance the search towards an HIV cure. We endeavored to understand perceptions of this research and to identify ethical and practical considerations relevant to implementing it. Methods: We conducted 20 in-depth interviews and 3 virtual focus groups among four types of key stakeholders in the United States (PWH, biomedical HIV cure researchers, HIV clinicians, and bioethicists) to obtain triangulated viewpoints because little was known about the ethics of this topic. Each group was queried as to ethical considerations, safeguards, and protections for conducting HIV cure-related research at the EOL to ensure this research remains acceptable. Results: All four key stakeholder groups generally supported HIV cure-related research conducted at the EOL because of the history of altruism within the PWH community and the potential for substantial scientific knowledge to be gained. Our informants expressed that: (1) Strong stakeholder and community involvement are integral to the ethical and effective implementation, as well as the social acceptability of this research; (2) PWH approaching the EOL should not inherently be considered a vulnerable class and their autonomy must be respected when choosing to participate in HIV cure-related research at the EOL; (3) Greater diversity among study participants, as well as multi-disciplinary research teams, is necessitated by HIV cure-related research at the EOL; (4) The sensitive nature of this research warrants robust oversight to ensure a favorable risk/benefit balance and to minimize the possibility of therapeutic misconception or undue influence; and (5) Research protocols should remain flexible to accommodate participants’ comfort and needs at the EOL. Conclusion: Because of the ethical issues presented by HIV cure-related research at the EOL, robust ethical safeguards are of utmost importance. The proposed ethical and practical considerations presented herein is a first step in determining the best way to maximize this research’s impact and social value. More much inquiry will need to be directed towards understanding context-specific and cultural considerations for implementing EOL HIV cure research in diverse settings

Ethical and practical considerations for interventional HIV cure-related research at the end-of-life: A qualitative study with key stakeholders in the United States

Background A unique window of opportunity currently exists to generate ethical and practical considerations presented by interventional HIV cure-related research at the end-of-life (EOL). Because participants would enroll in these studies for almost completely altruistic reasons, they are owed the highest ethical standards, safeguards, and protections. This qualitative empirical ethics study sought to identify ethical and practical considerations for interventional HIV cure-related research at the EOL. Methods and findings We conducted 20 in-depth interviews and three virtual focus groups (N = 36) with four key stakeholder groups in the United States: 1) bioethicists, 2) people with HIV, 3) HIV care providers, and 4) HIV cure researchers. This study produced six key themes to guide the ethical implementation of interventional HIV cure-related research at the EOL: 1) all stakeholder groups supported this research conditioned upon a clearly delineated respect for participant contribution and autonomy, participant understanding and comprehension of the risks associated with the specific intervention(s) to be tested, and broad community support for testing of the proposed intervention(s); 2) to ensure acceptable benefit-risk profiles, researchers should focus on limiting the risks of unintended effects and minimizing undue pain and suffering at the EOL; 3) only well-vetted interventions that are supported by solid pre-clinical data should be tested in the EOL translational research model; 4) the informed consent process must be robust and include process consent; 5) research protocols should be flexible and adopt a patient/participant centered approach to minimize burdens and ensure their overall comfort and safety; and 6) a participant’s next-of-kin/loved ones should be a major focus of EOL research but only if the participant consents to such involvement

Ethics of HIV cure research: an unfinished agenda

Background: The pursuit of a cure for HIV is a high priority for researchers, funding agencies, governments and people living with HIV (PLWH). To date, over 250 biomedical studies worldwide are or have been related to discovering a safe, effective, and scalable HIV cure, most of which are early translational research and experimental medicine. As HIV cure research increases, it is critical to identify and address the ethical challenges posed by this research. Methods: We conducted a scoping review of the growing HIV cure research ethics literature, focusing on articles published in English peer-reviewed journals from 2013 to 2021. We extracted and summarized key developments in the ethics of HIV cure research. Twelve community advocates actively engaged in HIV cure research provided input on this summary and suggested areas warranting further ethical inquiry and foresight via email exchange and video conferencing. Discussion: Despite substantial scholarship related to the ethics of HIV cure research, additional attention should focus on emerging issues in six categories of ethical issues: (1) social value (ongoing and emerging biomedical research and scalability considerations); (2) scientific validity (study design issues, such as the use of analytical treatment interruptions and placebos); (3) fair selection of participants (equity and justice considerations); (4) favorable benefit/risk balance (early phase research, benefit-risk balance, risk perception, psychological risks, and pediatric research); (5) informed consent (attention to language, decision-making, informed consent processes and scientific uncertainty); and (6) respect for enrolled participants and community (perspectives of people living with HIV and affected communities and representation). Conclusion: HIV cure research ethics has an unfinished agenda. Scientific research and bioethics should work in tandem to advance ethical HIV cure research. Because the science of HIV cure research will continue to rapidly advance, ethical considerations of the major themes we identified will need to be revisited and refined over time

Effects of deposition time and post-deposition annealing on the physical and chemical properties of electrodeposited CdS thin films for solar cell application

CdS thin films were cathodically electrodeposited by means of a two-electrode deposition system for different durations. The films were characterised for their structural, optical, morphological and compositional properties using x-ray diffraction (XRD), spectrophotometry, scanning electron microscopy (SEM) and energy dispersive x-ray (EDX) respectively. The results obtained show that the physical and chemical properties of these films are significantly influenced by the deposition time and post-deposition annealing. This influence manifests more in the as-deposited materials than in the annealed ones. XRD results show that the crystallite sizes of the different films are in the range (9.4 – 65.8) nm and (16.4 – 66.0) nm in the as-deposited and annealed forms respectively. Optical measurements show that the absorption coefficients are in the range (2.7×104 – 6.7×104) cm-1 and (4.3×104 – 7.2×104) cm-1 respectively for as-deposited and annealed films. The refractive index is in the range (2.40 – 2.60) for as-deposited films and come to the value of 2.37 after annealing. The extinction coefficient varies in the range (0.1 – 0.3) in asdeposited films and becomes 0.1 in annealed films. The estimated energy bandgap of the films is in the range (2.48 – 2.50) eV for as-deposited films and becomes 2.42 eV for all annealed films. EDX results show that all the films are S-rich in chemical composition with fairly uniform Cd/S ratio after annealing. The results show that annealing improves the qualities of the films and deposition time can be used to control the film thickness. Keywords: Electrodeposition; two-electrode system; CdS; annealing; deposition time; thin-film

Blinding for precision scattering experiments: The MUSE approach as a case study

Human bias is capable of changing the analysis of measured data sufficiently to alter the results of an experiment. It is incumbent upon modern experiments, especially those investigating quantities considered contentious in the broader community, to blind their analysis in an effort to minimize bias. The choice of a blinding model is experiment specific, but should also aim to prevent accidental release of results before an analysis is finalized. In this paper, we discuss common threats to an unbiased analysis, as well as common quantities that can be blinded in different types of nuclear physics experiments. We use the Muon Scattering Experiment as an example, and detail the blinding scheme used therein.Comment: 6 pages, 3 figure