A Hierarchical Taxonomy of Psychopathology (HiTOP) Primer for Mental Health Researchers

Mental health research is at an important crossroads as the field seeks more reliable and valid phenotypes to study. Dimensional approaches to quantifying mental illness operate outside the confines of traditional categorical diagnoses, and they are gaining traction as a way to advance research on the causes and consequences of mental illness. The Hierarchical Taxonomy of Psychopathology (HiTOP) is a leading dimensional research paradigm that synthesizes decades of data on the major dimensions of psychological disorders. In this article, we demonstrate how to use the HiTOP model to formulate and test research questions through a series of tutorials. To boost accessibility, data and annotated code for each tutorial are included at OSF ( https://osf.io/8myzw ). After presenting the tutorials, we outline how investigators can use these ideas and tools to generate new insights in their own substantive research programs

A population-based case-control study on social factors and risk of testicular germ cell tumours

Objectives Incidence rates for testicular cancer have risen over the last few decades. Findings of an association between the risk of testicular cancer and social factors are controversial. The association of testicular cancer and different indicators of social factors were examined in this study.<p></p> Design Case–control study.<p></p> Setting Population-based multicentre study in four German regions (city states Bremen and Hamburg, the Saarland region and the city of Essen).<p></p> Participants The study included 797 control participants and 266 participants newly diagnosed with testicular cancer of which 167 cases were classified as seminoma and 99 as non-seminoma. The age of study participants ranged from 15 to 69 years.<p></p> Methods Social position was classified by educational attainment level, posteducational training, occupational sectors according to Erikson-Goldthorpe-Portocarrero (EGP) and the socioeconomic status (SES) on the basis of the International SocioEconomic Index of occupational status (ISEI). ORs and corresponding 95% CIs (95% CIs) were calculated for the whole study sample and for seminoma and non-seminoma separately.<p></p> Results Testicular cancer risk was modestly increased among participants with an apprenticeship (OR=1.7 (95% CI 1.0 to 2.8)) or a university degree (OR=1.6 (95% CI 0.9 to 2.8)) relative to those whose education was limited to school. Analysis of occupational sectors revealed an excess risk for farmers and farm-related occupations. No clear trend was observed for the analyses according to the ISEI-scale.<p></p> Conclusions Social factors based on occupational measures were not a risk factor for testicular cancer in this study. The elevated risk in farmers and farm-related occupations warrants further research including analysis of occupational exposures.<p></p&gt

Pistons modeled by potentials

In this article we consider a piston modelled by a potential in the presence of extra dimensions. We analyze the functional determinant and the Casimir effect for this configuration. In order to compute the determinant and Casimir force we employ the zeta function scheme. Essentially, the computation reduces to the analysis of the zeta function associated with a scalar field living on an interval $[0,L]$ in a background potential. Although, as a model for a piston, it seems reasonable to assume a potential having compact support within $[0,L]$, we provide a formalism that can be applied to any sufficiently smooth potential.Comment: 10 pages, LaTeX. A typo in eq. (3.5) has been corrected. In "Cosmology, Quantum Vacuum and Zeta Functions: In Honour of Emilio Elizalde", Eds. S.D. Odintsov, D. Saez-Gomez, and S. Xambo-Descamps. (Springer 2011) pp 31

A stochastic template placement algorithm for gravitational wave data analysis

This paper presents an algorithm for constructing matched-filter template banks in an arbitrary parameter space. The method places templates at random, then removes those which are "too close" together. The properties and optimality of stochastic template banks generated in this manner are investigated for some simple models. The effectiveness of these template banks for gravitational wave searches for binary inspiral waveforms is also examined. The properties of a stochastic template bank are then compared to the deterministically placed template banks that are currently used in gravitational wave data analysis.Comment: 14 pages, 11 figure

On the Geometry of the Moduli Space of Real Binary Octics

The moduli space of smooth real binary octics has five connected components. They parametrize the real binary octics whose defining equations have 0, 1, ..., 4 complex-conjugate pairs of roots respectively. We show that the GIT-stable completion of each of these five components admits the structure of an arithmetic real hyperbolic orbifold. The corresponding monodromy groups are, up to commensurability, discrete hyperbolic reflection groups, and their Vinberg diagrams are computed. We conclude with a simple proof that the moduli space of GIT-stable real binary octics itself cannot be a real hyperbolic orbifold.Comment: 23 page

Exploring the Impact of Socio-Technical Core-Periphery Structures in Open Source Software Development

In this paper we apply the social network concept of core-periphery structure to the sociotechnical structure of a software development team. We propose a socio-technical pattern that can be used to locate emerging coordination problems in Open Source projects. With the help of our tool and method called TESNA, we demonstrate a method to monitor the socio-technical core-periphery movement in Open Source projects. We then study the impact of different core-periphery movements on Open Source projects. We conclude that a steady core-periphery shift towards the core is beneficial to the project, whereas shifts away from the core are clearly not good. Furthermore, oscillatory shifts towards and away from the core can be considered as an indication of the instability of the project. Such an analysis can provide developers with a good insight into the health of an Open Source project. Researchers can gain from the pattern theory, and from the method we use to study the core-periphery movements

Residue codes of extremal Type II Z_4-codes and the moonshine vertex operator algebra

In this paper, we study the residue codes of extremal Type II Z_4-codes of length 24 and their relations to the famous moonshine vertex operator algebra. The main result is a complete classification of all residue codes of extremal Type II Z_4-codes of length 24. Some corresponding results associated to the moonshine vertex operator algebra are also discussed.Comment: 21 pages, shortened from v

Helical Tubes in Crowded Environments

When placed in a crowded environment, a semi-flexible tube is forced to fold so as to make a more compact shape. One compact shape that often arises in nature is the tight helix, especially when the tube thickness is of comparable size to the tube length. In this paper we use an excluded volume effect to model the effects of crowding. This gives us a measure of compactness for configurations of the tube, which we use to look at structures of the semi-flexible tube that minimize the excluded volume. We focus most of our attention on the helix and which helical geometries are most compact. We found that helices of specific pitch to radius ratio 2.512 to be optimally compact. This is the same geometry that minimizes the global curvature of the curve defining the tube. We further investigate the effects of adding a bending energy or multiple tubes to begin to explore the more complete space of possible geometries a tube could form.Comment: 10 page

Women's Experiences of Preeclampsia: Australian Action on Preeclampsia Survey of Women and Their Confidants

Introduction. The experience of normal pregnancy is often disrupted for women with preeclampsia (PE). Materials and Methods. Postal survey of the 112 members of the consumer group, Australian Action on Pre-Eclampsia (AAPEC). Results. Surveys were returned by 68 women (61% response rate) and from 64 (57%) partners, close relatives or friends. Respondents reported experiencing pre-eclampsia (n = 53), eclampsia (n = 5), and/or Hemolysis, Elevated Liver enzymes, and Low Platelets (HELLP syndrome) (n = 26). Many women had no knowledge of PE prior to diagnosis (77%) and, once diagnosed, did not appreciate how serious or life threatening it was (50%). Women wanted access to information about PE. Their experience contributed substantial anxiety towards future pregnancies. Partners/friends/relatives expressed fear for the woman and/or her baby and had no prior understanding of PE. Conclusions. The PE experience had a substantial effect on women, their confidants, and their babies and affected their approach to future pregnancies. Access to information about PE was viewed as very important