13,513 research outputs found

    Optimised configuration of sensors for fault tolerant control of an electro-magnetic suspension system

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    For any given system the number and location of sensors can affect the closed-loop performance as well as the reliability of the system. Hence, one problem in control system design is the selection of the sensors in some optimum sense that considers both the system performance and reliability. Although some methods have been proposed that deal with some of the aforementioned aspects, in this work, a design framework dealing with both control and reliability aspects is presented. The proposed framework is able to identify the best sensor set for which optimum performance is achieved even under single or multiple sensor failures with minimum sensor redundancy. The proposed systematic framework combines linear quadratic Gaussian control, fault tolerant control and multiobjective optimisation. The efficacy of the proposed framework is shown via appropriate simulations on an electro-magnetic suspension system

    Convex Independence in Permutation Graphs

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    A set C of vertices of a graph is P_3-convex if every vertex outside C has at most one neighbor in C. The convex hull \sigma(A) of a set A is the smallest P_3-convex set that contains A. A set M is convexly independent if for every vertex x \in M, x \notin \sigma(M-x). We show that the maximal number of vertices that a convexly independent set in a permutation graph can have, can be computed in polynomial time

    Effect of various dopant elements on primary graphite growth

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    Five spheroidal graphite cast irons were investigated, a usual ferritic grade and four pearlitic alloys containing Cu and doped with Sb, Sn and Ti. These alloys were remelted in a graphite crucible, leading to volatilization of the magnesium added for spheroidization and to carbon saturation of the liquid. The alloys were then cooled down and maintained at a temperature above the eutectic temperature. During this step, primary graphite could develop showing various features depending on the doping elements added. The largest effects were that of Ti which greatly reduces graphite nucleation and growth, and that of Sb which leads to rounded agglomerates instead of lamellar graphite. The samples have been investigated with secondary ion mass spectrometry to enlighten distribution of elements in primary graphite. SIMS analysis showed almost even distribution of elements, including Mg and Al (from the inoculant) in the ferritic grade, while uneven distribution was evident in all doped alloys. Investigations are going on to clarify if the uneven distribution is associated with structural defects in the graphite precipitates

    Statistics on Logic Simulation

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    The high costs associated with logic simulation of large VLSI based systems have led to the need for new computer architectures tailored to the simulation task. Such architecture have the potential for significant speedups over standard software based logic simulators. Several commercial simulation engines have been produced to satisfy need in this area. To properly explore the space of alternative simulation architectures, data is required on the simulation process itself. This paper presents a framework for such data gathering activity by first examining possible sources of speedup in the logic simulation task, examining the sort of data needed in the design of simulation engines, and then presenting such data. The data contained in the paper includes information on the subtask times found in standard discrete event simulation algorithms, event intensities, queue length distributions and simultaneous event distributions

    Mitochondrial aconitase and citrate metabolism in malignant and nonmalignant human prostate tissues

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    BACKGROUND: In prostate cancer, normal citrate-producing glandular secretory epithelial cells undergo a metabolic transformation to malignant citrate-oxidizing cells. m-Aconitase is the critical step involved in this altered citrate metabolism that is essential to prostate malignancy. The limiting m-aconitase activity in prostate epithelial cells could be the result of a decreased level of m-aconitase enzyme and/or the inhibition of existing m-aconitase. Earlier studies identified zinc as an inhibitor of m-aconitase activity in prostate cells; and that the depletion of zinc in malignant cells is an important factor in this metabolic transformation. However, a possibility remains that an altered expression and level of m-aconitase enzyme might also be involved in this metabolic transformation. To address this issue, the in situ level of m-aconitase enzyme was determined by immunohistochemical analysis of prostate cancer tissue sections and malignant prostate cell lines. RESULTS: The immunocytochemical procedure successfully identified the presence of m-aconitase localized in the mitochondrial compartment in PC-3, LNCaP, and DU-145 malignant prostate cell lines. The examination of prostate tissue sections from prostate cancer subjects demonstrated that m-aconitase enzyme is present in the glandular epithelium of normal glands, hyperplastic glands, adenocrcinomatous glands, and prostatic intraepithelial neoplastic foci. Quantitative analysis of the relative level of m-aconitase in the glandular epithelium of citrate-producing adenomatous glands versus the citrate-oxidizing adenocarcinomatous glands revealed no significant difference in m-aconitase enzyme levels. This is in contrast to the down-regulation of ZIP1 zinc transporter in the malignant glands versus hyperplastic glands that exists in the same tissue samples. CONCLUSION: The results demonstrate the existence of m-aconitase enzyme in the citrate-producing glandular epithelial cells; so that deficient m-aconitase enzyme is not associated with the limiting m-aconitase activity that prevents citrate oxidation in these cells. The level of m-aconitase is maintained in the malignant cells; so that an altered enzyme level is not associated with the increased m-aconitase activity. Consequently, the elevated zinc level that inhibits m-aconitase enzyme is responsible for the impaired citrate oxidation in normal and hyperplastic prostate glandular epithelial cells. Moreover, the down-regulation of ZIP1 zinc transporter and corresponding depletion of zinc results in the increase in the activity of the existing m-aconitase activity in the malignant prostate cells. The studies now define the mechanism for the metabolic transformation that characterizes the essential transition of normal citrate-producing epithelial cells to malignant citrate-oxidizing cells

    Radio-frequency discharges in Oxygen. Part 1: Modeling

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    In this series of three papers we present results from a combined experimental and theoretical effort to quantitatively describe capacitively coupled radio-frequency discharges in oxygen. The particle-in-cell Monte-Carlo model on which the theoretical description is based will be described in the present paper. It treats space charge fields and transport processes on an equal footing with the most important plasma-chemical reactions. For given external voltage and pressure, the model determines the electric potential within the discharge and the distribution functions for electrons, negatively charged atomic oxygen, and positively charged molecular oxygen. Previously used scattering and reaction cross section data are critically assessed and in some cases modified. To validate our model, we compare the densities in the bulk of the discharge with experimental data and find good agreement, indicating that essential aspects of an oxygen discharge are captured.Comment: 11 pages, 10 figure

    Post impact evaluation of an E-learning cross-infection control CD-ROM provided to all general dental practitioners in England

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    Aim To carry out a post-impact evaluation of a cross-infection control CD-ROM, developed for NHS dental teams as a continuing professional development e-learning tool. The program was commissioned by the Department of Health and developed by a project team through the UK Committee of Postgraduate Dental Deans. The Dental Practice Boardhad originally sent one copy of the CD-ROM to each dental practice in England in 2004. Method A quantitative statistical analysis of the results of 326 online respondents to the learning package and a survey of 118 dental practitioners drawn from the Dental Practice Board database. Results Practitioners felt the CD-ROM in this instance was well designed and appropriate for their needs. It is inclusive and accessible to a wide range of dental professionals including nurses and hygienists. Conclusions This form of continuing professional development is popular with dental practitioners, although it should not be the only form of continuing professional development available. However, whilst the project was generally regarded as successful, there were problems with the distribution of the CD-ROM. This suggests that anonline resource should be made available in the future

    Multidimensional Longwave Forcing of Boundary Layer Cloud Systems

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    This is the publisher's version, also available electronically from http://journals.ametsoc.org/doi/abs/10.1175/2008JAS2733.1.The importance of multidimensional (MD) longwave radiative effects on cloud dynamics is evaluated in an eddy-resolving model (ERM)—the two-dimensional analog to large-eddy simulation (LES)—framework employing multidimensional radiative transfer [Spherical Harmonics Discrete Ordinate Method (SHDOM)]. Simulations are performed for a case of unbroken, marine boundary layer stratocumulus and a broken field of trade cumulus. “Snapshot” calculations of MD and independent pixel approximation (IPA; 1D) radiative transfer applied to simulated cloud fields show that the total radiative forcing changes only slightly, although the MD effects significantly modify the spatial structure of the radiative forcing. Simulations of each cloud type employing MD and IPA radiative transfer, however, differ little. For the solid cloud case, relative to using IPA, the MD simulation exhibits a slight reduction in entrainment rate and boundary layer total kinetic energy (TKE) relative to the IPA simulation. This reduction is consistent with both the slight decrease in net radiative forcing and a negative correlation between local vertical velocity and radiative forcing, which implies a damping of boundary layer eddies. Snapshot calculations of the broken cloud case suggest a slight increase in radiative cooling, although few systematic differences are noted in the interactive simulations. This result is attributed to the fact that radiative cooling is a relatively minor contribution to the total energetics. For the cloud systems in this study, the use of IPA longwave radiative transfer is sufficiently accurate to capture the dynamical behavior of boundary layer clouds. Further investigations are required to generalize this conclusion for other cloud types and longer time integrations

    Weak charge form factor and radius of 208Pb through parity violation in electron scattering

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    We use distorted wave electron scattering calculations to extract the weak charge form factor F_W(q), the weak charge radius R_W, and the point neutron radius R_n, of 208Pb from the PREX parity violating asymmetry measurement. The form factor is the Fourier transform of the weak charge density at the average momentum transfer q=0.475 fm1^{-1}. We find F_W(q) =0.204 \pm 0.028 (exp) \pm 0.001 (model). We use the Helm model to infer the weak radius from F_W(q). We find R_W= 5.826 \pm 0.181 (exp) \pm 0.027 (model) fm. Here the exp error includes PREX statistical and systematic errors, while the model error describes the uncertainty in R_W from uncertainties in the surface thickness \sigma of the weak charge density. The weak radius is larger than the charge radius, implying a "weak charge skin" where the surface region is relatively enriched in weak charges compared to (electromagnetic) charges. We extract the point neutron radius R_n=5.751 \pm 0.175 (exp) \pm 0.026 (model) \pm 0.005 (strange) fm$, from R_W. Here there is only a very small error (strange) from possible strange quark contributions. We find R_n to be slightly smaller than R_W because of the nucleon's size. Finally, we find a neutron skin thickness of R_n-R_p=0.302\pm 0.175 (exp) \pm 0.026 (model) \pm 0.005 (strange) fm, where R_p is the point proton radius.Comment: 5 pages, 1 figure, published in Phys Rev. C. Only one change in this version: we have added one author, also to metadat
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