Evaluation of Wound Healing Actions of Hoslundia opposita Vahl, Anthocleista nobilis G. Don. and Balanites aegyptiaca L.

Hoslundia opposita, Anthocleista nobilis and Balanites aegyptiaca are widely used ethnomedicinally in Ghana in the treatment of skin diseases. In this context, antimicrobial potential of the three plant species against a wide range of microorganisms was studied. To validate the ethnotherapeutic claims of these plants in skin diseases, in vivo wound healing activity was studied, besides antioxidant activity to understand the mechanism of wound healing. Methanol extract of Hoslundia opposita showed significant antibacterial activity against all bacteria tested including some resistant strains of Staphyloccocus aureus,/i>, with MIC ranging between 64-256 μg/ml. The results show that all three extracts have potent wound healing activity as evident from the wound contraction, increased tensile strength and hydroxyproline content. The results also indicated that the three plant species possess potent antioxidant activity by inhibiting lipid peroxidation, bleaching DPPH radical and protecting against oxidant injury to fibroblast cells. Keywords: Wound healing; antioxidant; Hoslundia opposita; Anthocleista nobilis; Balanites aegyptiaca. Journal of Science and Technology Vol. 28 (2) 2008: pp. 26-3

Friedelin: A bacterial resistance modulator from Paulinia Pinnata L.

As part of the project to identify plant natural products which modulate bacterial multidrug resistance (MDR), bioassay-guided isolation of the methanol extract of Paullinia pinnata L. roots yielded four known compounds namely friedelin, â-sitosterol, â-sitosterol acetate and â-sitosterol Dglucoside. The structures were established by spectroscopic methods and comparison with published data. These compounds were tested for in vitro antibacterial and resistance modifying activities against strains of Staphylococcus aureus; SA1199B, RN4220 and XU212 possessing the Tet(K), Msr(A), and Nor(A) multidrug resistance efflux mechanisms respectively. At 10ìg/ml, none of the compounds displayed any antibacterial action but in combination with tetracycline, erythromycin andnorfloxacin, friedelin displayed a 2-fold, 4-fold and 16-fold potentiation of activities of these antibiotics against XU212, SA1199B and RN4220 possessing the Tet(K) [tetracycline resistant], Nor(A)[norfloxacin resistant] and Msr(A) [macrolide resistant] transporters respectively

The role of research in higher education: implications and challenges for an active future contribution to human and social development

Mankind is on the brink of a tragic era, in which the anarchic forces of the market and the incessant pressures upon natural resources on the verge of exhaustion will push sovereign states to increasingly dangerous rivalries. What will the role of research in higher education be, in response to the challenge of an active future contribution to human and social development? A good balance must be reached in the basic functions of research in order to avoid governance risks. While focusing only on the transformative function of research may pose dangers to the human dimension and development, unilateral concentration on responsible development aspects may generate reactive approaches and delay economic benefits. Disregarding the inclusiveness function may lead to slower development and even isolationism, and focusing on short-term issues is not good for long-term goals and future generations. We must reinforce research networks between ‘Southern’ and ‘Northern’, rich and poor, and developed and developing countries and institutions in order to bridge the gap between knowledge consumers and producers. This paper reviews aspects such as development, globalization and the inequality of nations; constraints and choices of the orthodox views of research; rethinking research and higher education to contribute to a better future; and knowledge integration for effective action.Peer Reviewe

E-Learning Innovations: Implementation of Video in an Occupational Therapy Classroom

Given the growing emphasis on educational technology, it is necessary to inform educators on the best use of video as a course study tool. The aim of this project was to assess the difference between two types of video delivery methods in relation to occupational therapy student satisfaction and usage. Eighty-nine occupational therapy students used one of two types of video delivery methods for learning upper extremity goniometry: short videos embedded within e-learning modules or live lab video recordings available via a learning management system. Qualitative and quantitative data on student perceptions and usage were collected and analyzed. Students with access to e-learning module videos were more satisfied than those with access to live video recordings in terms of preparedness for exams, confidence, and accessibility. All students reported that access to videos was helpful in preparing for labs and exams. To maximize student satisfaction and usage, educators should consider providing short videos via e-learning modules

Trichilia monadelpha Bark Extracts Inhibit Carrageenan-Induced Foot-Oedema in the 7-Day Old Chick and the Oedema Associated with Adjuvant-Induced Arthritis in Rats

Trichilia monadelpha (Thonn) JJ De Wilde (Meliaceae) bark extract is used in African traditional medicine for the management of various disease conditions including inflammatory disorders such as arthritis. The present study was undertaken to evaluate the anti-inflammatory properties of aqueous (TWE), alcoholic (TAE) and petroleum ether extract (TPEE) of T. monadelpha using the 7-day old chick-carrageenan footpad oedema (acute inflammation) and the adjuvant-induced arthritis model in rats (chronic inflammation). TWE and TPEE significantly inhibited the chick-carrageenan footpad oedema with maximal inhibitions of 57.79±3.92 and 63.83±12 respectively, but TAE did not. The reference anti-inflammatory drugs (diclofenac and dexamethasone) inhibited the chick-carrageenan-induced footpad oedema, with maximal inhibitions of 64.92±2.03 and 71.85±15.34 respectively. Furthermore, all the extracts and the reference anti-inflammatory agents (diclofenac, dexamethasone, methotrexate) inhibited the inflammatory oedema associated with adjuvant arthritis with maximal inhibitions of 64.41±5.56, 57.04±8.57, 62.18±2.56%, for TWE, TAE and TPEE respectively and 80.28±5.79, 85.75±2.96, 74.68±3.03% for diclofenac, dexamethasone and methotrexate respectively. Phytochemical screening of the plant bark confirmed the presence of a large array of plant constituents such as alkaloids, glycosides, flavonoids, saponins, steroids, tannins and terpenoids, all of which may be potential sources of phyto-antiinflammatory agents. In conclusion, our work suggests that T. monadelpha is a potential source of antiinflammatory agents.Keywords: Antiinflammatory, Arthritis, Trichilia monadelpha, chick-carrageenan, phyto-antiinflammatory

Effects of infestation by cowpea aphid (Homoptera: Aphididae) on different growth stages of resistant and susceptible cowpea cultivars

Field studies were conducted to characterise the effects of infestations by adult and nymphal stages of cowpea aphid, Aphis craccivora Koch, on the growth and yield of cowpea, Vigna unguiculata (L.) Walp. Seedling, flowering, and podding stage plants of aphid-resistant (cv. ICV-12) and aphid-susceptible (cv. ICV-1) cowpea cultivars were used in the studies. Four treatments (consisting of infestations with adult and nymphal aphids, caged controls and uncaged controls) were administered on plants for 22 days post-treatment. Eight parameters of crop success were measured: extended leaf heights (ELH); plant mortality; incidence of sooty mould; incidence and abundance of natural enemy species; crop growth parameters (net assimilation rate, [NAR] in g/ dm2/day, and crop growth rate [CGR] in g/dm2 land surface/day); and plant yields (seeds per pod, weight per seed). Data were analysed using analysis of variance (ANOVA), orthogonal contrasts and 95% confidence intervals (C.I.). There were no significant (P > 0.05) differences between adult and nymphal infestations or between caged and uncaged controls, so the respective sets of data were combined for comparisons of aphid infestations with control treatments. Infestations caused severe plant stunting and other growth deformities, drastic yield reductions, higher plant mortality, greater incidence of natural enemies and abundance of Cheilomenes spp. on cv. ICV-1 than on cv. ICV-12, and on infested and uninfested plants. Aphid infestations did not significantly affect the incidence of sooty mould on plants of cv. ICV-12 or cv. ICV-

A Contactless IoT-Based GPS-Tracked Waste Bin to Curb Medical Waste Infections in Ghana

Irregular checking of waste especially in some medical facilities of Ghana leads to overflow of waste. A study by World Health Organisation (WHO) in February 2018 indicates that 15% of the total waste collected from medical facilities may be infectious, toxic, or radioactive and may contribute to unintended release of chemical or biological hazards. Considering the present COVID-19 pandemic and other diseases like ebola and hantavirus, it is critical to properly manage waste collected from medical facilities. In this study, Internet of Things (IoT) is used to design a smart bin to help reduce user contact to waste. Using a flowchart, a schematic model of the system was developed using Proteus 8.11 software. Two HCSR04 ultrasonic sensors were used to measure the waste level in the bin and detect proximity of objects to the bin to trigger an MG996R servo motor for automatic operation of the lid of the waste bin having a monitoring system. A NEO-6M GPS module was used to determine the location of the waste bin and displayed on a 16x2 LCD. A Graphical User Interface (GUI) was created for remote monitoring of waste over the internet. An ESP32 node MCU was programmed using Arduino software and used to interface the system with the GUI. The designed system was constructed and incorporated into a rectangular-shaped plastic bin. During testing, a hand wave at the sensor on the side of the container triggered opening of the bin. Sample waste placed in the bin were detected and real-time information regarding waste levels were sent to a self-designed HTML webpage called ‘Smart Bin’ with dynamic IP address. This system could be used in health facilities to prevent medical waste overflow, limit human contact to waste and avoid spread of infections

The home and school environments, physical activity levels, and adiposity indices of school-age children

The home and school environments as well as physical activity may be linked to the development of childhood obesity. We evaluated the home and school environments (HSEs), physical activity levels (PAL), television viewing (TVV) and their associations with adiposity indices of school-age children. This cross-sectional study included children aged 6-12 years and their parents from Tamale, Ghana. HSEs and TVV were assessed using questionnaires. The physical activity questionnaire for children (PAQ-C) was used to assess children’s PALs. Weight, height and waist circumferences were measured using standard tools. About 45% of children lived within a walking distance to parks or outdoor recreation centres. Majority of the parents considered their neighbourhoods to be safe for children to engage in physical activity. Only 27% of the schools had a food and nutrition policy, and more than 70% had a field for outdoor activities. Children watched TV for an average of 1.7 hours/day. Mean physical activity scores was 2.51. The school-age children had mean (SD) BMI-for-age z-scores was -0.23(1.47). Time spent watching TV or playing video games was associated with children’s BMI-for-age z-scores (β=0.48, p=0.043), BMI (β=2.28 p=0.005), and % body fat (β=3.80, p=0.005). Child’s level of activity was negatively associated with waist circumference (β =-0.65, p<0.001). Lack of nutrition policy in schools was common. TVV hours predisposed children to excess weight whiles physical activity decreased the likelihood of being obese.

Characterization of the dominant microorganisms responsible for the fermentation of dehulled maize grains into nsiho in Ghana

Nsiho (white kenkey) is a type of kenkey, a sour stiff dumpling, produced from fermented maize meal in Ghana. The dominant microorganisms responsible for the fermentation of nsiho were characterized by analysing samples from four traditional production sites at Anum in the Eastern Region of Ghana. During 48 h of steeping dehulled maize grains, the pH values decreased from 6.05 to 5.93 to 3.59 to 3.55, whilst titratable acidity increased from 0.02 to 0.03 to 0.27 to 0.32%. In the subsequent 12 h dough fermentation, the pH decreased from 6.02 to 5.80 to 3.52 to 3.46, whilst titratable acidity increased from 0.25 to 0.27 to 0.35 to 0.38%. The lactic acid bacteria population increased by 2 to 5 log units to concentrations of 107 to 108 CFU/ml during steeping and by 2 to 3 log units from 105 to 106 CFU/g to 108 to 109 CFU/g during dough fermentation. Yeasts counts increased by 3 to 4 log units during steepingand by 2 to 4 log units during dough fermentation. The most frequently isolated lactic acid bacteria responsible for nsiho fermentation were identified as Lactobacillus fermentum (47.1%), Lactobacillus brevis (25%), Lactobacillus plantarum (14.42%), Pediococcus pentosaceus (8.65%) and Pediococcus acidilactici, (4.8%). The dominant yeasts species were Saccharyomyces cerevisiae (47.6%), Candida krusei (29.1%),  Debaryomyces spp., (15%) and Trichosporon spp., (8.3%). This is the first  study to report on the micororganisms involved in nsiho fermentation.Key words: Nsiho, dehulled maize, kenkey, lactic acid bacteria, indigenous African fermented foods