Report on the first phase of the study on men’s usage of the Bradford Health of Men services

This is a summary of the full report on the first year of the HOM project in Bradford, published in March 2005 and available at www.healthofmen.com . In this summary there is a concentration on three things, the background to the project, the experiences of the HOM team in setting up and managing projects and the views of the men involved in the projects. The summary is mostly a list of the things that the team found to be important in setting up projects and, equally important, some of the things not to do. There is, of course, a much fuller discussion of the details of projects, supporting data and the theoretical model of how men and health workers interact to manage health

The Bradford & Airedale Health of Men initiative: a study of its effectiveness in engaging with men

The Health of Men (HoM) network received funding from the Big Lottery Fund in 2003 to establish a five year programme of dedicated work with men and boys. This enabled a team of practitioners to be creative and to build upon their existing skills to generate models of working with those men in the community that are usually seen as hard to reach. The research which has accompanied of the work of team has explored why men use these new services and has demonstrated the following: • Men do care about their health • Men are willing and able to engage with their health when services are tailored to their needs • Men from different culture groups and socio-economic backgrounds who are normally seen as hard to reach were accessed. • A model encompassing a dedicated team working with men is worthy of further development Much has been learnt from this project that has great relevance to the local Primary Care Trust (PCT), but has also proved a great source of information for the development of services to men on a Regional, National and International level

Accountability in patenting of federally funded research

Bayh-Dole allows academic grantees to patent federally-funded research for purposes of promoting the commercialization of this research. To ensure commercialization goals are achieved, the Act requires grantees to report to funding agencies not only the existence of federally-funded patents but also utilization efforts they and their licensees/assignees are making. Although reporting is a cornerstone of accountability under Bayh-Dole, information about grantee compliance with reporting requirements is incomplete and dated. In fact, the last significant study of the question dates back to the late 1990s and analyzes only 633 patents. Since that time, concerns have emerged that federally-funded university patents are being asserted improperly against independent commercializers or even assigned to so-called “patent trolls.” This article provides fresh evidence indicating substantial under-reporting of the existence of federal funding in over 30,000 academic biomedical patents issued between 1980 to 2007. The article finds substantial under-reporting of federal funding even in the case of patents on FDA-approved drugs, which should presumably receive significant attention from universities. Grantees’ failure to report federal funding suggests similar, or even more significant, noncompliance with requirements to report utilization information. However, compliance with reporting requirements on utilization cannot be assessed because of secrecy associated with relevant government databases. Accordingly, the article makes a fresh argument that the Commerce Department, which has the requisite regulatory authority, work with funding agencies, to improve transparency. Greater transparency would not only motivate grantees to improve reporting but would also allow assessment of whether grantee patent management is actually achieving Bayh-Dole\u27s utilization goals

Boundedness of Pseudodifferential Operators on Banach Function Spaces

We show that if the Hardy-Littlewood maximal operator is bounded on a separable Banach function space $X(\mathbb{R}^n)$ and on its associate space $X'(\mathbb{R}^n)$, then a pseudodifferential operator $\operatorname{Op}(a)$ is bounded on $X(\mathbb{R}^n)$ whenever the symbol $a$ belongs to the H\"ormander class $S_{\rho,\delta}^{n(\rho-1)}$ with $0<\rho\le 1$, $0\le\delta<1$ or to the the Miyachi class $S_{\rho,\delta}^{n(\rho-1)}(\varkappa,n)$ with $0\le\delta\le\rho\le 1$, $0\le\delta0$. This result is applied to the case of variable Lebesgue spaces $L^{p(\cdot)}(\mathbb{R}^n)$.Comment: To appear in a special volume of Operator Theory: Advances and Applications dedicated to Ant\'onio Ferreira dos Santo

Self-care in primary care: findings from a longitudinal comparison study.

To examine the effects of self-care training workshops for primary healthcare workers on frequently attending patients

Hybrid copula mixed models for combining case-control and cohort studies in meta-analysis of diagnostic tests

Copula mixed models for trivariate (or bivariate) meta-analysis of diagnostic test accuracy studies accounting (or not) for disease prevalence have been proposed in the biostatistics literature to synthesize information. However, many systematic reviews often include case-control and cohort studies, so one can either focus on the bivariate meta-analysis of the case-control studies or the trivariate meta-analysis of the cohort studies, as only the latter contains information on disease prevalence. In order to remedy this situation of wasting data we propose a hybrid copula mixed model via a combination of the bivariate and trivariate copula mixed model for the data from the case-control studies and cohort studies, respectively. Hence, this hybrid model can account for study design and also due to its generality can deal with dependence in the joint tails. We apply the proposed hybrid copula mixed model to a review of the performance of contemporary diagnostic imaging modalities for detecting metastases in patients with melanoma

No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML 10 and 12 trials

Fetal liver tyrosine kinase 3 (FLT3) internal tandem duplications (ITDs) are powerful adverse prognostic indicators for relapse in acute myelold leukemia (AML) but the most efficacious therapy for FLT3/ ITD+ patients is currently unknown. We evaluated outcome according to FLT3/ITD status in 1135 adult patients treated according to United Kingdom Medical Research Council (UK MRC) AML protocols: 141 received an autograft, and 170 received a matched sibling allograft in first complete remission (CR). An FLT3/ITD was detected in 25% of patients and was an independent predictor for relapse (P < .001). It remained prognostic for increased relapse in patients who received a transplant (odds ratio [OR] = 1.91; 95% confidence intervals [CIs] 1.13-3.21; P = .02), with no evidence of a difference in effect between patients who received an autograft (OR = 2.39; CIs = 1.24-4.62) and patients who received an allograft (OR = 1.31; CIs = 0.56-3.06) (test for interaction, P = .3) or between patients who did or did not receive a transplant (P = .4). These results were confirmed in an analysis of 186 patients randomized to receive or not receive an autograft in first CR and in a donor-versus-no donor analysis of 683 patients to assess the role of allograft (for latter, FLT3/ITD- OR = 0.70, CIs = 0.53-0.92; FLT3/ITD+ OR = 0.59, CIs = 0.40-0.87; test for interaction, P = .5). These results suggest that at present there is no strong evidence that FLT3 status should influence the decision to proceed to transplantation

Simulation of surface effects in energy dissipation of ultrahighfrequency (UHF) nanocantilevers

Devices composed of nanoelectromechanical systems (NEMS) possess distinguished properties which make them quite suitable for a variety of applications including ultra-high-frequency (UHF) resonators. However, most GHz resonators have low quality factor even though it has been well above 10 3∼ 10 5 for very-high-frequency (VHF) microresonators. The motivation for our investigation of single crystal silicon nanoresonator arises from both its technological importance and its extraordinary surface effects. Our simulation results show that the quality factor decreased in a nearly linear manner as the surface area to volume ratio (SVR) was increased, which suggests that surface losses play a significant role in determining the quality factor of nanoresonators.published_or_final_versio

Wet Process Induced Phase Transited Drug Delivery System as a Means for Delivery of Gastrointestinal Irritant Drug: Histomorphological Analysis

A non-disintegrating, asymmetric membrane capsular system for a poorlywater soluble drug, flurbiprofen, was developed and evaluated in vitro andin vivo. Asymmetric membrane capsules were made by phase inversion. Theeffect of varying osmotic pressure of the dissolution medium on drug releasewas studied. Acute toxicity studies and histomorphological analysis wereconducted in rats. Scanning electron microscopy showed an outer denseregion with few pores and an inner porous region on the preparedasymmetric membrane. Statistical tests on in vitro release studies wereapplied at p>0.05. The drug release was found to be independent of the pHbut dependent on the osmotic pressure of the dissolution medium. Theresults of in vivo toxicity studies may support the use of phase transitedasymmetric membrane capsules as a means for delivery of gastro-intestinalirritant drugs in a controlled manner through Fickian diffusion