18 research outputs found
Vortex phase diagram in BSCCO with damage tracks created by 30 MeV fullerene irradiation
Using 30 MeV C60 fullerene irradiation, we have produced latent tracks of
diameter 20 nm and length 200 nm, near the surface of single crystalline BSCCO.
A preliminary transmission electron microscopy study shows evidence for a very
high density of deposited energy, and the ejection of material from the track
core in very thin specimens. The latent tracks reveal themselves to be
exceptionally strong pinning centers for vortices in the superconducting mixed
state. Both the critical current density and magnetic irreversibility line are
significantly enhanced. The irradiated crystals present salient features of the
(B,T) phase diagram of vortex matter both of pristine crystals, such as the
first order vortex phase transition, and the exponential Bose-glass line
characteristic of heavy ion-irradiated crystals. We show that the latter is
manifestly independent of the pinning potential.Comment: 10 pages, 13 figure
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven lung cancer was assessed. A3B expression in EGFR mutant (EGFRmut) non-small-cell lung cancer (NSCLC) mouse models constrained tumorigenesis, while A3B expression in tumors treated with EGFR-targeted cancer therapy was associated with treatment resistance. Analyses of human NSCLC models treated with EGFR-targeted therapy showed upregulation of A3B and revealed therapy-induced activation of nuclear factor kappa B (NF-ÎşB) as an inducer of A3B expression. Significantly reduced viability was observed with A3B deficiency, and A3B was required for the enrichment of APOBEC mutation signatures, in targeted therapy-treated human NSCLC preclinical models. Upregulation of A3B was confirmed in patients with NSCLC treated with EGFR-targeted therapy. This study uncovers the multifaceted roles of A3B in NSCLC and identifies A3B as a potential target for more durable responses to targeted cancer therapy.</p
The genetic mating system of a sea spider with male-biased sexual size dimorphism: evidence for paternity skew despite random mating success
Male-biased size dimorphism is usually expected to evolve in taxa with intense male–male competition for mates, and it is hence associated with high variances in male mating success. Most species of pycnogonid sea spiders exhibit female-biased size dimorphism, and are notable among arthropods for having exclusive male parental care of embryos. Relatively little, however, is known about their natural history, breeding ecology, and mating systems. Here we first show that Ammothella biunguiculata, a small intertidal sea spider, exhibits male-biased size dimorphism. Moreover, we combine genetic parentage analysis with quantitative measures of sexual selection to show that male body size does not appear to be under directional selection. Simulations of random mating revealed that mate acquisition in this species is largely driven by chance factors, although actual paternity success is likely non-randomly distributed. Finally, the opportunity for sexual selection (Is), an indirect metric for the potential strength of sexual selection, in A. biunguiculata males was less than half of that estimated in a sea spider with female-biased size dimorphism, suggesting the direction of size dimorphism may not be a reliable predictor of the intensity of sexual selection in this group. We highlight the suitability of pycnogonids as model systems for addressing questions relating parental investment and sexual selection, as well as the current lack of basic information on their natural history and breeding ecology