507 research outputs found
The Islamists Are Coming!
In an effort to counter the unfruitful labelling practices that have characterized dialogue between Western and Muslim Worlds, the German government in cooperation with the Zentrum Moderner Orient invited Southeast Asian Islamists to Berlin to engage in a more fruitful exchange of viewpoints. The authors point out that although the discussions did not necessary lead to agreement, the encounters did create room for nuance and understanding
Properties of Foreshocks and Aftershocks of the Non-Conservative SOC Olami-Feder-Christensen Model: Triggered or Critical Earthquakes?
Following Hergarten and Neugebauer [2002] who discovered aftershock and
foreshock sequences in the Olami-Feder-Christensen (OFC) discrete block-spring
earthquake model, we investigate to what degree the simple toppling mechanism
of this model is sufficient to account for the properties of earthquake
clustering in time and space. Our main finding is that synthetic catalogs
generated by the OFC model share practically all properties of real seismicity
at a qualitative level, with however significant quantitative differences. We
find that OFC catalogs can be in large part described by the concept of
triggered seismicity but the properties of foreshocks depend on the mainshock
magnitude, in qualitative agreement with the critical earthquake model and in
disagreement with simple models of triggered seismicity such as the Epidemic
Type Aftershock Sequence (ETAS) model [Ogata, 1988]. Many other features of OFC
catalogs can be reproduced with the ETAS model with a weaker clustering than
real seismicity, i.e. for a very small average number of triggered earthquakes
of first generation per mother-earthquake.Comment: revtex, 19 pages, 8 eps figure
Ligand binding and conformational dynamics of the E. coli nicotinamide nucleotide transhydrogenase revealed by hydrogen/deuterium exchange mass spectrometry
Nicotinamide nucleotide transhydrogenases are integral membrane proteins that utilizes the proton motive force to reduce NADP+ to NADPH while converting NADH to NAD+. Atomic structures of various transhydrogenases in different ligand-bound states have become available, and it is clear that the molecular mechanism involves major conformational changes. Here we utilized hydrogen/deuterium exchange mass spectrometry (HDX-MS) to map ligand binding sites and analyzed the structural dynamics of E. coli transhydrogenase. We found different allosteric effects on the protein depending on the bound ligand (NAD+, NADH, NADP+, NADPH). The binding of either NADP+ or NADPH to domain III had pronounced effects on the transmembrane helices comprising the proton-conducting channel in domain II. We also made use of cyclic ion mobility separation mass spectrometry (cyclic IMS-MS) to maximize coverage and sensitivity in the transmembrane domain, showing for the first time that this technique can be used for HDX-MS studies. Using cyclic IMS-MS, we increased sequence coverage from 68 % to 73 % in the transmembrane segments. Taken together, our results provide important new insights into the transhydrogenase reaction cycle and demonstrate the benefit of this new technique for HDX-MS to study ligand binding and conformational dynamics in membrane proteins
Evidence for strong relations between the upper Tagus loess formation (central Iberia) and the marine atmosphere off the Iberian margin during the last glacial period
During glacial times, the North Atlantic region was affected by serious climate changes corresponding to Dansgaard-Oeschger cycles that were linked to dramatic shifts in sea temperature and moisture transfer to the continents. However, considerable efforts are still needed to understand the effects of these shifts on terrestrial environments. In this context, the Iberian Peninsula is particularly interesting because of its close proximity to the North Atlantic, although the Iberian interior lacks paleoenvironmental information so far because suitable archives are rare. Here we provide an accurate impression of the last glacial environmental developments in central Iberia based on comprehensive investigations using the upper Tagus loess record. A multi-proxy approach revealed that phases of loess formation during Marine Isotope Stage (MIS) 2 (and upper MIS 3) were linked to utmost aridity, coldness, and highest wind strengths in line with the most intense Greenland stadials also including Heinrich Events 3â1. Lack of loess deposition during the global last glacial maximum (LGM) suggests milder conditions, which agrees with less-cold sea surface temperatures (SST) off the Iberian margin. Our results demonstrate that geomorphological system behavior in central Iberia is highly sensitive to North Atlantic SST fluctuations, thus enabling us to reconstruct a detailed hydrological model in relation to marineâatmospheric circulation patterns
Results from 730 kg days of the CRESST-II Dark Matter Search
The CRESST-II cryogenic Dark Matter search, aiming at detection of WIMPs via
elastic scattering off nuclei in CaWO crystals, completed 730 kg days of
data taking in 2011. We present the data collected with eight detector modules,
each with a two-channel readout; one for a phonon signal and the other for
coincidently produced scintillation light. The former provides a precise
measure of the energy deposited by an interaction, and the ratio of
scintillation light to deposited energy can be used to discriminate different
types of interacting particles and thus to distinguish possible signal events
from the dominant backgrounds. Sixty-seven events are found in the acceptance
region where a WIMP signal in the form of low energy nuclear recoils would be
expected. We estimate background contributions to this observation from four
sources: 1) "leakage" from the e/\gamma-band 2) "leakage" from the
\alpha-particle band 3) neutrons and 4) Pb-206 recoils from Po-210 decay. Using
a maximum likelihood analysis, we find, at a high statistical significance,
that these sources alone are not sufficient to explain the data. The addition
of a signal due to scattering of relatively light WIMPs could account for this
discrepancy, and we determine the associated WIMP parameters.Comment: 17 pages, 13 figure
The CRESST II Dark Matter Search
Direct Dark Matter detection with cryodetectors is briefly discussed, with
particular mention of the possibility of the identification of the recoil
nucleus. Preliminary results from the CREEST II Dark Matter search, with 730
kg-days of data, are presented. Major backgrounds and methods of identifying
and dealing with them are indicated.Comment: Talk at DSU workshop, ITP Beijing, Oct. 2011. 9 figures, 2 table
A detector module with highly efficient surface-alpha event rejection operated in CRESST-II Phase 2
The cryogenic dark matter experiment CRESST-II aims at the direct detection
of WIMPs via elastic scattering off nuclei in scintillating CaWO crystals.
We present a new, highly improved, detector design installed in the current run
of CRESST-II Phase 2 with an efficient active rejection of surface-alpha
backgrounds. Using CaWO sticks instead of metal clamps to hold the target
crystal, a detector housing with fully-scintillating inner surface could be
realized. The presented detector (TUM40) provides an excellent threshold of
keV and a resolution of keV (at
2.60keV). With significantly reduced background levels, TUM40 sets
stringent limits on the spin-independent WIMP-nucleon scattering cross section
and probes a new region of parameter space for WIMP masses below
3GeV/c. In this paper, we discuss the novel detector design and the
surface-alpha event rejection in detail.Comment: 9 pages, 6 figure
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