Asking For Help: Survey and Experimental Evidence on Financial Advice and Behavior Change

When do individuals actually improve their financial behavior in response to advice? Using survey data from current defined contribution (DC) plan holders in the RAND American Life Panel (ALP), we find little correlation between normatively-desirable behaviors and advice. Results from a hypothetical portfolio-allocation choice experiment using the ALP show that unsolicited advice has no causal effect on investment behavior, yet individuals who actively solicit advice ultimately improve performance, despite negative selection on financial ability. While expanding access to advice can have positive effects (particularly for the less financially literate), more extensive compulsory programs of financial counseling may be less effective

Interleukin 2 restores CD3-zeta chain expression but fails to generate tumour-specific lytic activity in tumour-infiltrating lymphocytes derived from human colorectal hepatic metastases.

Metastatic colorectal cancer is usually progressive despite infiltration of the tumours by T lymphocytes, suggesting that these tumour-infiltrating lymphocytes (TILs) are functionally deficient. Recently, TILs from other tumours have been shown to express reduced levels of the T-cell receptor signal-transducing CD3-zeta chain. We were interested to determine whether a similar abnormality existed in TILs from human colorectal hepatic metastasis (CHM) and, if so, whether correcting the abnormality in vitro would restore anti-tumour activity and provide support for the development of immunotherapy for colorectal hepatic metastases. Twelve of 19 TILs from colorectal hepatic metastases were successfully expanded in vitro in high-dose recombinant interleukin 2 (rlL-2) and their specific anti-tumour cytolytic activity was determined. CD3-positive (CD3+) TILs were HLA-Drhigh and CD69high, suggesting that they had been activated by exposure to antigen but expressed low levels of CD25, CD71 and the nuclear proliferation antigen Ki-67. Furthermore, they showed reduced expression of CD3-zeta compared with autologous peripheral blood T cells (PBTs) and failed to proliferate in the absence of high-dose rIL-2. Expansion of TILs in rIL-2 resulted in restoration of CD3-zeta expression and the ability to lyse K562 and Daudi cells but not autologous tumour cells. The absence of autologous tumour-specific cytolytic T-cell (CTL) activity may be due to the poor immunogenicity of colorectal tumour cells, which we found expressed only low levels of MHC I antigens and CD54 and failed to express MHC II antigens or the co-stimulatory molecules CD80, CD86 or CD106. The inability of rIL-2 to generate tumour-specific CTLs despite restoration of CD3-zeta expression and the presence of an intact lytic mechanism suggests that successful immunotherapy may require the development of strategies to increase the immunogenicity of this tumour

Prevalence and determinants of anxiety and depression in end stage renal disease (ESRD). A comparison between ESRD patients with and without coexisting diabetes mellitus

Objective: To compare anxiety and/or depressive symptoms between patients with end-stage renal disease with and without comorbid diabetes and identify factors associated with symptoms of distress in this population. Methods: Data from two studies (conducted between 2010 and 2014) were pooled. A total of 526 patients on hemodialysis (68.8% with diabetes) completed the Hospital Anxiety and Depression Scale (HADS). Elevated symptoms were defined as HADS-Anxiety or HADS-Depression ≥ 8. Univariate and multivariate logistic regressions were used to estimate associations between diabetic status, and other socio-demographic and clinical factors with baseline clinical anxiety and depression. Results: A total of 233 (45.4%) reported elevated anxiety symptoms and 256 (49.9%) reported elevated depressive symptoms sufficient for caseness. Rates were not different between patients with and without diabetes. Risk for clinical depression was higher in patients who were single/unpartnered (OR = 1.828), Chinese vs. Malay (OR = 2.05), or had lower albumin levels (OR = 0.932). None of the parameters were associated with anxiety caseness. Conclusion: Sociocultural factors rather than comorbid burden may help identify patients at risk for depression. The high rates of anxiety and depression underlie the importance for monitoring and intervention in dialysis care

A Circular Economy Framework based on Organic Wastes Upcycling for Biodiesel Production from Hermetia illucens

The present waste management practices have adverse environmental impacts at the same time costly. Approximately, 80 % of the Malaysian municipal wastes including organic wastes are usual disposed into landfills. Hence, transformation organic wastes not only providing economic and environmental benefits but has given waste a value. This study focused on synthesis of biodiesel from H. illucens pre-pupae fed with fruit waste and food waste. The objective was to evaluate interactions between the variables including catalyst loading, reaction time versus fatty acid methyl esters (FAME) yield (wt %), temperature and methanol to sample mass ratio. The response surface methodology (RSM) was used to investigate the bioconversion optimization process. Optimal biodiesel yield based on fruit waste achieved was 96.15 % at 51ºC; 8.3:1 methanol: mass ratio; 253 min and 15.1 % catalyst. Furthermore, the optimal yield obtained from the second set of optimization using lipids of pre-pupae derived from food waste was achieved at 94.63 %.  The optimum conditions for reaction temperature was 71°C, with methanol to mass ratio of 6.8:1, at reaction time of 254 min and catalyst loading of 7.0 v/v%. The properties of FAME produced were in accordance with EN 14214 and ASTM 6751 biodiesel standards

The role of wearable devices and objective gait analysis for the assessment and monitoring of patients with lumbar spinal stenosis: Systematic review

© 2019 The Author(s). Background: The purpose of this systematic review was to evaluate the accuracy and reliability of wearable devices for objective gait measurement of Lumbar Spinal Stenosis (LSS) patients, with a focus on relevant gait metrics. Methods: Systematic searches were conducted of five electronic databases to identify studies that assessed gait metrics by wearable or portable technology. Data was collected according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement guidelines. Results: Four articles were identified for inclusion in this review. The objectives, methodology and quality of the studies varied. No single gait metric was investigated in all four studies, making comparison difficult. The most relevant metrics reported included gait cycle, gait velocity, step length and cadence, which were reported in two studies. Two studies explored gait symmetry. Differences between LSS patients and normal healthy subjects are demonstrable using wearable technology. Conclusions: The measurements of gait cycle, cadence, step length, gait velocity, and number of steps with wearable devices can be used in the gait measurement of LSS patients for initial assessment, and objective outcomes following interventions. However, data and analysis are limited, and further studies are necessary to comment on reliability

Dynamical and stationary critical behavior of the Ising ferromagnet in a thermal gradient

In this paper we present and discuss results of Monte Carlo numerical simulations of the two-dimensional Ising ferromagnet in contact with a heat bath that intrinsically has a thermal gradient. The extremes of the magnet are at temperatures $T_1<T_c<T_2$, where $T_c$ is the Onsager critical temperature. In this way one can observe a phase transition between an ordered phase ($TT_c$) by means of a single simulation. By starting the simulations with fully disordered initial configurations with magnetization $m\equiv 0$ corresponding to $T=\infty$, which are then suddenly annealed to a preset thermal gradient, we study the short-time critical dynamic behavior of the system. Also, by setting a small initial magnetization $m=m_0$, we study the critical initial increase of the order parameter. Furthermore, by starting the simulations from fully ordered configurations, which correspond to the ground state at T=0 and are subsequently quenched to a preset gradient, we study the critical relaxation dynamics of the system. Additionally, we perform stationary measurements ($t\rightarrow\infty$) that are discussed in terms of the standard finite-size scaling theory. We conclude that our numerical simulation results of the Ising magnet in a thermal gradient, which are rationalized in terms of both dynamic and standard scaling arguments, are fully consistent with well established results obtained under equilibrium conditions

Stress-dependent generalized Prandtl–Ishlinskii hysteresis model of a NiTi wire with superelastic behavior

The extremely useful superelastic behavior of NiTi has been poorly explored because of the limited number of models that can describe the complete hysteretic behavior of NiTi, including a superelastic condition that strongly depends on the applied stress. This paper presents the development of a stress-dependent phenomenological model of NiTi by modifying the existing generalized Prandtl–Ishlinskii (GPI) model. The parameters of the envelop function of the GPI model’s play operator are reformulated as quadratic functions of the applied stress. The stress-dependent GPI model can satisfactorily predict the output strain of a NiTi #6 wire under temperature and stress variation

5-Year Follow-Up of a Telephone Intervention to Increase Fruit and Vegetable Consumption in Preschoolers: The ‘Healthy Habits’ Cluster Randomised Trial

Little is known about the long-term impact of telephone-based interventions to improve child diet. This trial aimed to assess the long-term effectiveness (after 5 years) of a telephone-based parent intervention in increasing children&rsquo;s fruit and vegetable consumption. Parents of 3&ndash;5 year olds were recruited from 30 Australian preschools to participate in a cluster randomised controlled trial. Intervention parents received four, weekly, 30-min support calls aimed at modifying the home food environment. Control parents received printed materials. Consumption was assessed using the Fruit and Vegetable subscale of the Children&rsquo;s Dietary Questionnaire (F&amp;V-CDQ) (children) and daily servings of fruit and vegetables (children and parents) via parent telephone interview. Of the 394 parents who completed baseline, 57% (99 intervention, 127 control) completed follow-up. After 5-years, higher intervention F&amp;V-CDQ scores, bordering on significance, were found in complete-case (+1.1, p = 0.06) and sensitivity analyses (+1.1, p = 0.06). There was no difference in parent or child consumption of daily fruit servings. Complete-case analysis indicated significantly higher consumption of child vegetable servings (+0.5 servings; p = 0.02), which was not significant in sensitivity analysis (+0.5 servings; p = 0.10). This telephone-based parent intervention targeting the family food environment may yield promising improvements in child fruit and vegetable consumption over a 5-year period

EVALUACIÓN DE LA FERTILIDAD in vitro DEL SEMEN DE TOROS JÓ- VENES NACIONALES EN OVOCITOS PROVENIENTES DE OVARIOS DE ANIMALES BENEFICIADOS

This study was carried out in the Center of Research and Instruction in Embryo Transfer (CIETE), sponsored by a partnership between the National Agrarian University of La Molina (UNALM) and the Ministry of Agriculture (MINAG), located at the UNALM campus. The objective was to evaluate the fertility and in vitro production of embryos of four bulls from the National Semen Bank. This study used 1031 oocytes of quality A and B obtained from ovaries of the local slaughterhouse. The oocytes were matured in the TCM-199 medium. The Percoll gradient centrifuge method was used for spermatic separation; sperm capacitation and fertilization was done in the TALP-IVF + PHE medium; and embryos were cultured with the Sofaa medium containing 5% Fetal Bovine Serum (FBS). Embryos were evaluated on days 7, 8, and 9 after fertilization. There were no statistical differences among the four bulls, and the fertilization rate was 63.3, 56.8, 68.8 and 72.9% for each bull. There was no statistical difference in the production of embryos between bulls. It is concluded that the bulls tested were in the normal range for in vitro embryo production.El presente trabajo se desarrolló en el Centro de Investigación y Enseñanza en Transferencia de Embriones (CIETE), convenio Universidad Nacional Agraria La Molina (UNALM) - Ministerio de Agricultura (MINAG); ubicado en el campus de la Universidad Nacional Agraria La Molina. El objetivo fue evaluar la fertilidad y la producción de embriones in vitro de cuatro toros provenientes del Banco Nacional de Semen. Se utilizaron 1031 ovocitos de calidad A y B aspirados de ovarios de vacas beneficiadas en el camal. Los ovocitos se maduraron en medio TCM-199. En la separación espermática se usó el método de centrifugación con gradientes de Percoll; la capacitación y fertilización se realizó en el medio TALP-IVF + PHE; y el cultivo de embriones se hizo con medio Sofaa + 5% de Suero Fetal Bovino (SFB). Los embriones fueron evaluados los días 7, 8 y 9 después de la fertilización. No se encontraron diferencias estadísticas entre los cuatro toros evaluados, siendo el porcentaje de fertilización de 63.3, 56.8, 68.8 y 72.9% para cada toro. Tampoco se encontró diferencias estadísticas en la producción de embriones entre toros. Se concluye que los toros evaluados se encuentran en el rango normal de producción de embriones in vitro

Interventions to prevent obesity in school-aged children 6-18 years: An update of a Cochrane systematic review and meta-analysis including studies from 2015–2021

Background Childhood obesity remains a global public health priority due to the enormous burden it generates. Recent surveillance data suggests there has been a sharp increase in the prevalence of childhood obesity during the COVID-19 pandemic. The Cochrane review of childhood obesity prevention interventions (0–18 years) updated to 2015 is the most rigorous and comprehensive review of randomised controlled trials (RCTs) on this topic. A burgeoning number of high quality studies have been published since that are yet to be synthesised. Methods An update of the Cochrane systematic review was conducted to include RCT studies in school-aged children (6-18 years) published to 30 June 2021 that assessed effectiveness on child weight (PROSPERO registration: CRD42020218928). Available cost-effectiveness and adverse effect data were extracted. Intervention effects on body mass index (BMI) were synthesised in random effects meta-analyses by setting (school, after-school program, community, home), and meta-regression examined the association of study characteristics with intervention effect. Findings Meta-analysis of 140 of 195 included studies (183,063 participants) found a very small positive effect on body mass index for school-based studies (SMD –0·03, 95%CI –0·06,–0·01; trials = 93; participants = 131,443; moderate certainty evidence) but not after-school programs, community or home-based studies. Subgroup analysis by age (6–12 years; 13–18 years) found no differential effects in any setting. Meta-regression found no associations between study characteristics (including setting, income level) and intervention effect. Ten of 53 studies assessing adverse effects reported presence of an adverse event. Insufficient data was available to draw conclusions on cost-effectiveness. Interpretation This updated synthesis of obesity prevention interventions for children aged 6–18 years, found a small beneficial impact on child BMI for school-based obesity prevention interventions. A more comprehensive assessment of interventions is required to identify mechanisms of effective interventions to inform future obesity prevention public health policy, which may be particularly salient in for COVID-19 recovery planning. Funding This research was funded by the National Health and Medical Research Council (NHMRC), Australia (Application No APP1153479)