BENUTZERADÄQUATE NAVIGATIONS- UND RECHERCHETECHNOLOGIEN FÜR VERTEILTE DYNAMISCHE DIGITALE BAUWERKSMODELLE

Hinsichtlich der Integration einzelner Bauwerkslebensphasen und der verschiedenen Beteiligten, insbesondere innerhalb von Bauplanungs- und Revitalisierungsprozessen, bestehen aktuell entscheidende Defizite. Die generelle Zielstellung der in diesem Beitrag vorgestellten Forschungsarbeiten besteht in der Unterstützung und Verbesserung der Integration durch die disziplin- und lebensphasenübergreifende Bereitstellung sämtlicher bauwerksbezogener Informationen. Dies erfordert einerseits geeignete Ansätze zur Modellierung und Integration der vielfältigen disziplinspezifischen Daten, andererseits geeignete Lösungen, die einen globalen Zugriff, Navigation und Recherche im Gesamtdatenbestand ermöglichen. Die Modellierung und Verwaltung bauwerksbezogener Daten ist seit längerem Gegenstand diverser Forschungsarbeiten. Im Rahmen des SFB 524 wurde ein eigener Ansatz basierend auf einem laufzeitdynamischen Partialmodellverbund entwickelt. Dieser wird in den wesentlichen Grundzügen anderen Ansätzen gegenübergestellt. Den Schwerpunkt dieses Beitrags bildet jedoch die Entwicklung einer geeigneten flexiblen Navigations- und Rechercheschicht zu Realisierung projektglobaler Informationsrecherche. Aus der Sicht der Modellierung und Datenverwaltung wie auch aus der Sicht der Informationsrecherche und Informationspräsentation in Planungsprozessen ergeben sich verschiedene Anforderungen an derartige Recherchewerkzeuge, wobei der wesentlichste Grundsatz maximale Flexibilität hinsichtlich verfügbarer Darstellungstechniken und deren freie Kombination mit Techniken formaler Suchanfragen ist. Das entwickelte Systemkonzept basiert auf einem Framework, welches verschiedene Grundtypen von Recherchemodulen und deren Interaktionsprinzipien vorgibt. Einzelne Recherchemodule werden als Ausprägungen dieser Modultypen realisiert und können je nach Bedarf laufzeitdynamisch in die Navigationsschicht integriert werden. Die technische Realisierung des Systems erfolgt im Umfeld vorhandener Prototypen aus vorangegangenen Forschungsaktivitäten. Dieses technische Umfeld gibt verschiedene Rahmenbedingungen vor, welche im Vorfeld prototypischer Implementierungen verschiedene Adaptionen des generellen Systemkonzepts notwendig machen. Der vorliegende Beitrag stellt den aktuellen Entwicklungsstand der Systemlösung aus konzeptioneller und technischer Sicht sowie erste prototypische Realisierungen von Recherchemodulen vor

Evaluation of predictive value of biochemical markers for adverse obstetrics outcomes in pregnancies complicated by cholestasis

Objectives: Intrahepatic cholestasis of pregnancy (ICP) is significantly more often associated with an abnormal perinataloutcome compared to a group of healthy pregnant women.The aim of the study was to analyse the correlation between the adverse perinatal outcome and the biochemical parametersin pregnancy complicated by cholestasis, and to assess their predictive value for neonatal complications.Material and methods: Eighty-six patients with ICP were divided into 3 groups according to their fasting serum bile acidlevel [group I n = 60, 10–39.90 μmol/L; group II n = 20, 40–99.90 μmol /L; group III n = 6, TBA (total bile acids) ≥ 100.00 μmol/L].Linear regression models were created to determine the relation of serum TBA, ALT, and AST concentration with total adverseperinatal outcome, defined as an occurrence of at least one perinatal outcome: stillbirth, preterm birth, spontaneous andiatrogenic preterm birth, presence of meconium in amniotic fluid, Apgar score (< 7 in 5th min), pH from umbilical artery(< 7.1), necessity for NICU admission, the presence of breathing disorders, and the need to perform phototherapy.Results: TBA ≥ 40.00 μmol/L is connected to an elevated risk of the occurrence of total adverse perinatal outcome (OR = 4.17,p = 0.0037, AUC = 0.62, p = 0.046). TBA ≥ 40.00 μmol/L is a predictor of preterm birth (OR 2.3, p = 0.0117), iatrogenic pretermbirth (OR 2.5, p = 0.006), admission to NICU (OR 2.38, p = 0.0094), intubation or assisted ventilation (OR 2.16, p = 0.0301), andphototherapy (OR 2.0, p = 0.0438). The threshold value of TBA for the need for phototherapy was 52.7 μmol/L (AUC = 0.67,p = 0.0089) and for preterm birth, 32.1 μmol/L (AUC = 0.62, p = 0.0251).Conclusions: Pregnant women with ICP and TBA serum level over 40.00 μmol/L have a worse prognosis regarding obstetricoutcomes. The concentration of bile acids is a predictor of the occurrence of adverse perinatal outcomes, although theconcentration of ALT and AST failed to show such a connection

The double [3+2] photocycloaddition reaction

One of a synthetic organic chemists‟ greatest challenges is to create step-efficient routes toward compounds with high molecular complexity. Therefore, reactions such as the meta photocycloaddition of an olefin to a benzene derivative, which provide more than one bond in a single step are of significant importance. It this remarkable reaction three new σ bonds, three new rings and up to six new stereocenters are formed simultaneously. Additional complexity can be added by tethering the two reacting partners together and this form of the reaction has found many uses in natural product synthesis. In this work a remarkable double [3+2] photocycloaddition reaction is reported that results in the formation of a complex cis, cis, cis, trans-[5, 5, 5, 5] fenestrane derivative from a simple flat aromatic acetal with two branching alkenes. During this dramatic transformation four carboncarbon bonds, five new rings and seven new stereocenters are created in a single one-pot process using only UV light. The reaction occurs in a sequential manner from the linear meta photocycloadduct, via a secondary [3+2] addition of the alkene across the cyclopropane of the adduct. In addition, an angular meta photocycloadduct also produced in the initial addition step, undergoes an alternative fragmentation-translocation photoreaction to afford a silphinene-like angular tricyclic compound. In this work the investigation of this newly discovered process is discussed via the synthesis and subsequent irradiation of a series of photosubstrates containing different functional groups in the arene-alkene tether. In addition, attempts toward the synthesis of alternative structures using the same double [3+2] photocycloaddition are reported

Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis

An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed

Modulating attentional load affects numerosity estimation: evidence against a pre-attentive subitizing mechanism

Traditionally, the visual enumeration of a small number of items (1 to about 4), referred to as subitizing, has been thought of as a parallel and pre-attentive process and functionally different from the serial attentive enumeration of larger numerosities. We tested this hypothesis by employing a dual task paradigm that systematically manipulated the attentional resources available to an enumeration task. Enumeration accuracy for small numerosities was severely decreased as more attentional resources were taken away from the numerical task, challenging the traditionally held notion of subitizing as a pre-attentive, capacity-independent process. Judgement of larger numerosities was also affected by dual task conditions and attentional load. These results challenge the proposal that small numerosities are enumerated by a mechanism separate from large numerosities and support the idea of a single, attention-demanding enumeration mechanism

Oligocarbonate Molecular Transporters: Oligomerization-Based Syntheses and Cell-Penetrating Studies

A new family of guanidinium-rich molecular transporters featuring a novel oligocarbonate backbone with 1,7-side chain spacing is described. Conjugates can be rapidly assembled irrespective of length in a one-step oligomerization strategy that can proceed with concomitant introduction of probes (or by analogy drugs). The new transporters exhibit excellent cellular entry as determined by flow cytometry and fluorescence microscopy, and the functionality of their drug delivery capabilities was confirmed by the delivery of the bioluminescent small molecule probe luciferin and turnover by its intracellular target enzyme

Are language production problems apparent in adults who no longer meet diagnostic criteria for attention-deficit/hyperactivity disorder?

In this study, we examined sentence production in a sample of adults (N = 21) who had had attention-deficit/hyperactivity disorder (ADHD) as children, but as adults no longer met DSM-IV diagnostic criteria (APA, 2000). This “remitted” group was assessed on a sentence production task. On each trial, participants saw two objects and a verb. Their task was to construct a sentence using the objects as arguments of the verb. Results showed more ungrammatical and disfluent utterances with one particular type of verb (i.e., participle). In a second set of analyses, we compared the remitted group to both control participants and a “persistent” group, who had ADHD as children and as adults. Results showed that remitters were more likely to produce ungrammatical utterances and to make repair disfluencies compared to controls, and they patterned more similarly to ADHD participants. Conclusions focus on language output in remitted ADHD, and the role of executive functions in language production

Designed Guanidinium-Rich Amphipathic Oligocarbonate Molecular Transporters Complex, Deliver and Release siRNA in Cells

The polyanionic nature of oligonucleotides and their enzymatic degradation present challenges for the use of siRNA in research and therapy; among the most notable of these is clinically relevant delivery into cells. To address this problem, we designed and synthesized the first members of a new class of guanidinium-rich amphipathic oligocarbonates that noncovalently complex, deliver, and release siRNA in cells, resulting in robust knockdown of target protein synthesis in vitro as determined using a dual-reporter system. The organocatalytic oligomerization used to synthesize these co-oligomers is step-economical and broadly tunable, affording an exceptionally quick strategy to explore chemical space for optimal siRNA delivery in varied applications. The speed and versatility of this approach and the biodegradability of the designed agents make this an attractive strategy for biological tool development, imaging, diagnostics, and therapeutic applications

Sixty Years of CA: A Cancer Journal for Clinicians

The first issue of CA: A Cancer Journal for Clinicians was published in November of 1950. On the 60th anniversary of that date, we briefly review several seminal contributions to oncology and cancer control published in our journal during its first decade. CA Cancer J Clin 2010. © 2010 American Cancer Society, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78301/1/20088_ftp.pd