Laboratory Profile of Adult Hemoglobinopathies Picked Up During Routine Health Check in a Tertiary Care Hospital from South India

Background and aim: Hemoglobin (Hb) variants can clinically range from being completely asymptomatic to frequent requirement of transfusions. Some individuals may become aware of a variant only when a complete blood count (CBC), hemoglobin analysis or genetic testing is done for a different reason. These individuals are typically heterozygous for an autosomal recessive variant. A study was conducted to find out the different types of hemoglobinopathies in adults presenting to a tertiary care hospital for routine health check and its geographic distribution. Objective: 1) To find out the severity of anemia associated with different hemoglobinopathies. 2) To find the relevance of glycated hemoglobin (HbA1c) in the presence of various hemoglobinopathies. Methods: A retrospective cross-sectional observational study was done in 111 consecutive patients who were found to have hemoglobinopathies during routine health checks in a tertiary care hospital in South India from 2013 to 2021. Results: One hundred eleven patients were found to have abnormality in Hb electrophoresis and there was a male predominance (69 patients, 62.2%). Majority of patients with beta-thalassemia (28 patients, 63.6%) were from West Bengal. Both HbE trait (17 patients, 65.4%) and homozygous HbE (23 patients, 62.2%) were from Assam. There was statistically significant distribution (p value 0.0001). HbA1c detected Hb variant in those with HbE disease. Conclusion: Hemoglobinopathies constitute a huge hereditary burden and a serious healthcare concern in India. Hence, it is the need of the hour to pick up such asymptomatic cases and provide appropriate premarital and prenatal counseling. Also, it is essential to devise strategies other than routine HbA1c testing to guide blood sugar control

Novel Proposed Work for Empirical Word Searching in Cloud Environment

People's lives have become much more convenient as a result of the development of cloud storage. The third-party server has received a lot of data from many people and businesses for storage. Therefore, it is necessary to ensure that the user's data is protected from prying eyes. In the cloud environment, searchable encryption technology is used to protect user information when retrieving data. The versatility of the scheme is, however, constrained by the fact that the majority of them only offer single-keyword searches and do not permit file changes.A novel empirical multi-keyword search in the cloud environment technique is offered as a solution to these issues. Additionally, it prevents the involvement of a third party in the transaction between data holder and user and guarantees integrity. Our system achieves authenticity at the data storage stage by numbering the files, verifying that the user receives a complete ciphertext. Our technique outperforms previous analogous schemes in terms of security and performance and is resistant to inside keyword guessing attacks.The server cannot detect if the same set of keywords is being looked for by several queries because our system generates randomized search queries. Both the number of keywords in a search query and the number of keywords in an encrypted document can be hidden. Our searchable encryption method is effective and protected from the adaptive chosen keywords threat at the same time

Evaluation of peripheral arterial occlusive disease by computed tomography angiography

Background: Characterization of peripheral arterial occlusive disease (PAOD) can be performed with non-invasive angiography using computed tomography (CT). The present study was conducted to evaluate the CT angiographic spectrum of aortoiliac and the lower limb arterial disease in symptomatic patients of peripheral arterial occlusive disease (PAOD) and to classify the lesions according to the Trans-Atlantic Inter-Society Consensus II (TASC II).Methods: The study was carried out in the department of radio-diagnosis in collaboration with departments of cardiothoracic surgery, cardiology and surgery, Safdarjung Hospital and Vardhman Mahavir Medical College, New Delhi. 50 patients aged above 40 years presenting with symptoms and (or) signs of lower limb peripheral arterial disease were recruited into the study after evaluating the renal function. Patient’s clinical history, ABI index and categories of PAOD according to the classification of Fontaine was noted. CT angiography of aortoiliac and lower limb arteries was performed with Philips Brilliance 40 CT unit. The findings in each CT angiography were analysed in respect to site, number, nature and distribution of the lesions and classified individually according to the TASC II.Results: The patients included in the study were all more than 40 years of age. The age range in the study group was 42 years to 75 years. The majority (86%) were male patients. Smoking and dyslipidemia were found to be the main risk factors in our patients. 24% of patients had documentary evidence of ischemic heart disease. On grading with ABI majority of patients (58%) presented in the end stage of the disease (stage IV). On CT angiography, number of lesions detected was 157. 97.4% of lesions were either stenotic or occlusive and 2.54% are with aneurysm. Maximum number of patients had femoropopliteal lesions followed by aortailiac lesions. 14 Winslow pathways were found in 10 patients. Maximum numbers of femoropopliteal lesions (47.29%) belong to type D, type B lesions account for 50% of total aortoiliac lesions based on TASC II classification. Out of 50, 40 were made follow up. Among them 8 were managed with conservative treatment and remaining 32 managed with treatment based TASC II classification.Conclusions: CT angiography is a reliable noninvasive imaging method for the comprehensive and multi parameter evaluation of patients with PAOD. CT angiographic findings are a highly accurate basis for treatment decisions and planning

DIVERSITY OF FRESHWATER ZOOPLANKTON IN COLLIDAM RIVER NEAR NEELATHANALLUR

Zooplankton plays an important role in aquatic ecosystem. They link primary producers, phytoplankton with higher larger tropic level organisms. Many aquatic organism exhibit diurnal rhythms in their activities,  although factors such as light, temperature, food, sex and size have been attributed as probable causes for such behavior of planktonic organisms. Zooplankton provides the necessary amount of protein required for the rapid growth and development of organs of fishes. The larvae of most fishes feed mostly on zooplankton. Growth and abundance of zooplankton varies with season and depth and depends upon meteorological and water properties. Temperature plays vital role in the vertical distribution of zooplankton. The work was conducted by the monthly changes in zooplankter recorded in coleroon  river, situated near by Neelathanallur (Thanjavur district)

Eigen Value Analysis for Sub Synchronous Resonance Mitigation in Transmission Lines

Series compensation for transmission line is vital as it increases the electricity switch capability of a transmission line. Employing series reimbursement also ends in phenomenon of sub synchronous resonance (SSR) wherein, the electrical and mechanical herbal frequencies suit and alternate strength leading to excitation of herbal torsional modes of the turbine generator unit. Thyristor controlled series capacitor (TCSC) has made it viable for the short manipulate of power go with the flow within the transmission line. The side-line of TCSC is to boom transmission traces functionality and also damps out sub-synchronous resonances (SSR) as result of energy oscillation damping. It has been known due to the fact a long time that series reimbursement for fixed capacitors is a both value and useful resource effective manner of enhancing strength float in comparison to conventional production of recent traces. It turned into generally believed that 70% reimbursement may be used with none hassle up to 1971. It was learnt that constant series reimbursement can motive sub-synchronous resonance (SSR) through 1971. The TCSC is a reactive electricity compensating flexible alternating current transmission system tool for many advantages which include variable compensation and strength manipulate. A controller that's able to SSR detection as soon because the guide transfer is put on is designed, which is sub synchronous damping controller (SSDC). SSDC detects the sub synchronous resonance phenomenon and directs the correct sign of the TCSC. TCSC can in all likelihood mitigate the SSR. In this papers Eigen price evaluation technique and manipulate of strength machined oscillations the usage of TCSC was advanced. The description of energy machine oscillations using the Eigen values and eigenvectors of the state matrix are in element. The effectiveness of the method used improves the transmission functionality

Correlation and Regression of Weed, ‎Growth and Yield Attributes of Transplanted Pearl Millet (Pennisetum ‎glaucum (L.) R. Br. Emend. Stunz)‎ as Affected by Weed Management Practices

To evaluate the “Correlation and regression of weed, ‎growth and yield attributes of transplanted Pearl millet (Pennisetum ‎glaucum (L.) R. Br. Emend. Stunz)‎ as affected by weed management practices‎”. And the design of the trial was Randomized Complete Block Design (RBD).The field trial was conducted during the Rabi season 2022 at Experimental farm, Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu. The experiment consisted of eight different treatments for weed management practices was replicated thrice. The soil type used was silty clay loam. The Pearl millet TNAU cumbu hybrid (CO9) was sown in the nursery and transplanted at 18 DAS and transplanted with a spacing of 45 x 15 cm. The following treatments were applied: T1 - PE of Atrazine 0.5 kg ha-1, T2 - PE of Oxyflurofen 0.250 kg ha-1, T3 - PE of Pendimethalin 0.75 kg ha-1, T4 - T1+ Hand Weeding on 30 DAT, T5 - T2+ Hand Weeding on 30 DAT, T6 - T3+ Hand Weeding on 30 DAT, T7 - Hand Weeding on 20 and 40 DAT and T8 - Unweeded check. Correlation analysis in weed management research assists researchers in assessing the strength and direction of relationships between variables. By understanding these relationships, researchers can gain insights into the factors influencing weed growth and develop focused management strategies. Moreover, correlation and regression studies provide valuable information for decision-making in weed management. The analysis showed positive correlation between grain yield and growth parameters viz., plant height at harvest (r = 0.965), LAI at 45 DAT (r = 0.852), DMP at 45 DAT (r = 0.971) and DMP at harvest (r = 0.973). Grain yield showed positive correlation with yield attributes, WCE and nutrient content viz., Productive tillers (r = 0.987), test weight (r =0.994), stover yield (r = 0.981), Weed Control Efficiency (r = 0.931), nitrogen uptake (r = 0.980), phosphorous uptake (r = 0.979) and potassium uptake (r = 0.962).This information can guide farmers, agronomists, and policymakers in making informed choices regarding management practices, resource allocation, and minimizing the economic and environmental impacts of weeds

Evaluate the Correlation and Regression Studies of Growth, Yield Attributes and Yield of Transplanted Finger Millet (Eleusine coracana L. Gaertn) under Different Weed Management

Aim: To evaluate the “Correlation and Regression Studies of Growth, Yield Attributes and Yield of finger millet under different weed management.” Study Design: Randomized Complete Block Design (RBD). Place and Duration of Study: The field trial was conducted during the Rabi season of 2021-22 at Karunya Institute of Technology and Sciences, Coimbatore, Tamil Nadu. The experimental field had a silky clay loam soil composition. Methodology: The field trial comprised of eight treatments and was replicated three times. In the experimental farm, the variety Paiyur 2 was grown into nursery and transplanted at 25th day with the spacing of 30 × 15 cm and followed the all other agronomic practices. To experimented the following treatments viz., T1- PE of pretilachlor at 1.0 kg ha-1,T2- PE of pretilachlor at 0.75 kg ha-1+ one hand weeding on 35th DAT, T3-  PE of pendimethalin at 0.5 kg ha-1,T4- PE of pendimethalin at 0.5 kg ha-1+ one hand weeding on 35th DATP, T5- PE of Butachlor at 1.0 kg ha-1,T6- PE of Butachlor at 0.75 kg ha-1+ one hand weeding on 35th DAT, T7-  POE of 2,4-D at 2 kg ha-1on 35 th DAT, T8-  POE of 2,4-D at 2 kg ha-1+ one hand weeding on 35th DAT, T9- Two hand weeding at 35 DAT and 70 DAT, T10- Unweeded check. The biometric observations were recorded at three specific time points: 35 DAT, 70 DAT, and at harvest stage. Results:  The grain yield was highly significant positive correlation with Straw yield (r = 0.893), Leaf area index (r =0.975), Dry matter accumulation at 70 DAT (r=0.966), Dry matter accumulation at harvest (r =0.966), Productive tillers (r =0.902), Test weight (r =0.903), Weed control efficiency (r =0.797), Nitrogen uptake (r =0.980), Phosphorus uptake (r =0.972), Potassium uptake (r =0.960). However, significant positive correlation with Plant height (r =0.733). From the regression every unit increase in stover yield, plant height, LAI at 70 DAT, crop dry matter at 70 DAT, crop dry matter at harvest, number of productive tillers plant-1, test weight, Weed Control Efficiency and N, P and K uptake by crop substantially increased the grain yield by 0.798, 0.537, 0.951, 0.932, 0.992, 0.812, 0.865, 0.635, 0.960, 0.944 and 0.920 kg ha-1 respectively

Melorheostosis: Two atypical cases

Melorheostosis is an uncommon mesenchymal dysplasia that rarely affects the axial skeleton.We describe two atypical cases of melorheostosis with classical imaging findings - the first one involving the cervico-dorsal spine with encroachment of left vertebral artery canal causing attenuation of the left vertebral artery and the second one of mixed sclerosing bony dysplasia (monomelic involvement coexisting with osteopoikilosis)

Correlation and Regression Studies of Growth, Yield Attributes, Yield and Nutrient Uptake of Foxtail Millet under Different Varieties and Landraces

Aims: To evaluate the “Correlation and Regression Studies of Growth, Yield Attributes and Yield of foxtail millet (Setaria italica L.) Under Different Varieties and Landraces”. Place and Duration of Study: The experiment was carried out in the Rabi season of 2022-23 at Experimental farm in Karunya Institute of Technology and Sciences, Coimbatore. Experimental field was silty clay loam in texture with medium in available N (273.0 kg/ha), high in available P2O5 (21.5 kg/ha) and high in available K2O (425.0 kg/ha) and lower level of organic carbon (0.29%). Study Design: Randomized Block Design (RBD). Methodology: The treatments consisted of 8 foxtail millet varieties and landraces viz., T1 - ATL-1 (Control), T2 - SiA-3222 (Garuda), T3 - SiA-3088 (Suryanandhi), T4 - SiA-3085, T5 - SiA-3156, T6 - SiA-3233 (Reynaudu), T7 - Mookanthathinai and T8 - Koranthinai. Results: Grain yield was highly significant positive correlation with N uptake (r = 0.996**), DMP at harvest stage (r = 0.984**), K uptake (r = 0.981**), P uptake (r = 0.966**) and straw yield (r = 0.954**). From the regression, N uptake (R2 = 0.993**), DMP (R2 = 0.968**) at harvest is the important positive component of grain yield in foxtail millet followed by K uptake (R2 = 0.962**), P uptake (R2 = 0.934**) and straw yield (R2 = 0.911**). Conclusion: From the result of correlation and regression, it was concluded that in terms of grain yield, the foxtail millet varieties and landraces are influenced by the DMP at harvest stage, N uptake, K uptake, P uptake and Straw yield