BIODIVERSITAS IKAN KARANG DI WILAYAH BENTANG LAUT LESSER SUNDA BANDA (KAB. FLORES TIMUR, ALOR DAN MALUKU BARAT DAYA), INDONESIA

Sebanyak 62 titik penyelaman dilakukan untuk memberi gambaran mengenai ikan karang yang terdapat di wilayah perbatasan Propinsi NTT dan Maluku di Indonesia. Tutupan karang hidup menunjukan umumnya kondisi tutupan karang berada pada kategori baik dengan nilai rata-rata 62,51%. Ikan karang yang ditemukan dalam survei ini terdiri dari 468 spesies dalam 47 Famili ikan karang dimana biomassa ikan karang tertinggi terdapat Kab. MBD (Rata-rata 12.476,32 Kg/Ha) sedangkan yang terendah terdapat di Kab. Flores Timur (rata-rata 652,83 Kg/Ha). Nilai Kelimpahan ikan karang tertinggi terdapat di Kab. MBD (rata-rata 13.308 Ind/Ha) dan yang terendah terdapat di Kab. Flores Timur (rata-rata 1.502.23 Ind/Ha). Struktur komunitas ikan karang berdasarkan indeks shanon-weinner (H’) berada kategori sedang, nilai indeks keseragaman (E) masuk kategori labil dan nilai dominansi (C) masuk dominansi rendah sehingga ekosistem masih dalam kondisi baik. Kesamaan spesies ikan karang menggunakan hasil cluster analysis pada taraf penskalaan 66,37 % dan MDS (Multi Dimensional Scalling) mengelompokkan ikan karang kedalam 2 grup yaitu ikan karang di wilayah Kab. Alor dan Flores Timur dan Kabupaten Maluku Barat Daya di kolompok lainnya. Hasil dari analisis klatser dan MDS memperlihatkan Kab. Alor dan Flores timur di Provinsi NTT yang masuk wilayah geografis Lesser Sunda memiliki perbedaan ikan karang dengan Kab. Maluku Barat Daya di Provinsi Maluku yang secara geografis masuk area Banda seascapes. Secara keseluruhan ikan karang di Kab. MBD memiliki potensi yang sangat tinggi dilihat dari kelimpahan, biomasa dan nilai ekologi lainnya. Lokasi ini bisa dikembangkan menjadi sumber protein hewani yang potensial bagi masyarakat disana maupun tingkat nasional.Kata kunci: Ikan karang, Biomassa, kelimpahan, Lesser sunda, Flores Timur, Alor, Maluku Barat Daya. REEF FISHES BIODIVERSITY OF LESSER SUNDA-BANDA SEASCAPE (EAST FLORES, ALOR AND SOUTH WEST MALUKU DISTRICT) IN INDONESIAABSTRACT A total of 62 dive sites were made to provide an overview of reef fish found in the border region of the Province of NTT and Maluku in Indonesia. Live coral cover shows the general condition of the coral cover is in good category with an average value of 62.51%. Reef fish found in this survey consists of 468 species in 47 Famili reef fish reef where fish biomass is highest Kab. MBD (average 12.476,32 kg.ha-1), while the lowest was in the district. East Flores (an average of 652,83 kg.ha-1). The value of reef fish abundance is highest in the district MBD (average 13.308 ind.ha-1) and the lowest was in the district East Flores (average 1.502,23 ind.ha-1). Reef fish community structure based-weinner Shannon index (H') was the medium category, evenness indice value (E) in the category volatile and the value of dominance (C) enters a low dominance so that the ecosystem is still in good condition. The similarity of species of reef fish using cluster analysis results at the level of scaling 66.37% and MDS (Multi Dimensional Scaling) breaks down into two groups of reef fish that reef fish in the district Alor and East Florest and district of Southwest Maluku in other group. Results of the cluster analysis and MDS showed Alor and East Flores regency in NTT Prvince incoming Lesser Sunda seascapes have different reef fish by the District of Southwest Maluku in Maluku Province incoming Sunda Banda seascapes. Overall reef fish in the district. MBD has a very high potential views of abundance, biomass and other ecological values. This location can be developed into a potential source of animal protein for the people there as well as national level. Keywords: Reef fishes, biomass, abundance, Lesser Sunda, sunda banda seascap

Effects of abstinence on brain morphology in alcoholism: A MRI study

Chronic alcohol abuse leads to morphological changes of the brain. We investigated if these volumetric changes are reversible after a period of abstinence. For this reason 41 male and 15 female alcohol patients underwent MRI-scanning after in-patient detoxification (baseline) entering alcoholism treatment programs, and between 6 and 9 months later (follow-up), in a phase of convalescence. Additionally, 29 male and 16 female control subjects were examined. The MRI-scans were delineated and the resulting regions of interest, volumes of lateral ventricles and prefrontal lobes were expressed relatively to total brain volume. Compared to control subjects alcohol patients showed bilaterally decreased prefrontal lobes (11% reduction) and increased lateral ventricles (up to 42% enlargement). The extent of the ventricular increase was depending on patient’s additional psychiatric diagnosis, showing smaller lateral ventricles in patients with additional personality disorder. While at follow-up the size of prefrontal lobes remained unchanged, volumes of the lateral ventricles decreased (5–6% reduction) in alcohol patients with abstinence and improved drinking behavior, especially in patients that underwent only one detoxification. The extent of the ventricular enlargement correlated with the elevation of alcohol related laboratory measures (mean corpuscular volume, gamma-glutamyl transpeptidase). In conclusion this study confirms the hypothesis that alcoholism causes brain damages that are partially reversible. It should be analyzed in further studies with larger sample sizes, if complete brain regeneration is possible maintaining abstinence over a longer period

Efficacy and moderators of efficacy of cognitive behavioural therapies with a trauma focus in children and adolescents: an individual participant data meta-analysis of randomised trials

Background: Existing clinical trials of cognitive behavioural therapies with a trauma focus (CBTs-TF) are underpowered to examine key variables that might moderate treatment effects. We aimed to determine the efficacy of CBTs-TF for young people, relative to passive and active control conditions, and elucidate putative individual-level and treatment-level moderators. Methods: This was an individual participant data meta-analysis of published and unpublished randomised studies in young people aged 6-18 years exposed to trauma. We included studies identified by the latest UK National Institute of Health and Care Excellence guidelines (completed on Jan 29, 2018) and updated their search. The search strategy included database searches restricted to publications between Jan 1, 2018, and Nov 12, 2019; grey literature search of trial registries ClinicalTrials.gov and ISRCTN; preprint archives PsyArXiv and bioRxiv; and use of social media and emails to key authors to identify any unpublished datasets. The primary outcome was post-traumatic stress symptoms after treatment (<1 month after the final session). Predominantly, one-stage random-effects models were fitted. This study is registered with PROSPERO, CRD42019151954. Findings: We identified 38 studies; 25 studies provided individual participant data, comprising 1686 young people (mean age 13·65 years [SD 3·01]), with 802 receiving CBTs-TF and 884 a control condition. The risk-of-bias assessment indicated five studies as low risk and 20 studies with some concerns. Participants who received CBTs-TF had lower mean post-traumatic stress symptoms after treatment than those who received the control conditions, after adjusting for post-traumatic stress symptoms before treatment (b=-13·17, 95% CI -17·84 to -8·50, p<0·001, τ2=103·72). Moderation analysis indicated that this effect of CBTs-TF on post-traumatic stress symptoms post-treatment increased by 0·15 units (b=-0·15, 95% CI -0·29 to -0·01, p=0·041, τ2=0·03) for each unit increase in pre-treatment post-traumatic stress symptoms. Interpretation: This is the first individual participant data meta-analysis of young people exposed to trauma. Our findings support CBTs-TF as the first-line treatment, irrespective of age, gender, trauma characteristics, or carer involvement in treatment, with particular benefits for those with higher initial distress

Bipolar disorders

Bipolar disorder is characterized by (hypo)manic episodes and depressive episodes which alternate with euthymic periods. It causes serious disability with poor outcome, increased suicidality risk, and significant societal costs. This chapter describes the findings of the PET/SPECT research efforts and the current ideas on the pathophysiology of bipolar disorder. First, the cerebral blood flow and cerebral metabolism findings in the prefrontal cortex, limbic system, subcortical structures, and other brain regions are discussed, followed by an overview of the corticolimbic theory of mood disorders that explains these observations. Second, the neurotransmitter studies are discussed. The serotonin transporter alterations are described, and the variation in study results is explained, followed by an overview of the results of the various dopamine receptor and transporter molecules studies, taking into account also the relation to psychosis. Third, a concise overview is given of dominant bipolar disorder pathophysiological models, proposing starting points for future molecular imaging studies. Finally, the most important conclusions are summarized, followed by remarks about the observed molecular imaging study designs specific for bipolar disorder.</p

Laparoscopy-Assisted Percutaneous Cholangiography in Biliary Atresia Diagnosis: Comparison with Open Technique

Introduction. Biliary atresia is a surgical cause of prolonged jaundice, which needs to be diagnosed with cholangiography that has traditionally been performed via laparotomy. Laparoscopic assistance has lately been introduced to avoid unnecessary laparotomy. We aim to evaluate the benefits of the laparoscopy-assisted cholangiography and compare it to the traditional procedure via laparotomy. Patients and Method. The medical records of the cases who had undergone cholangiography for prolonged jaundice between 2007 and 2014 were analyzed. The patients were grouped according to cholangiography technique (laparotomy/laparoscopy). The laparoscopy and laparotomy groups with patent bile ducts were focused and compared in terms of operation duration, postoperative initiation time of enteral feeding, and full enteral feeding achievement time. Results. Sixty-one infants with prolonged jaundice were evaluated between 2007 and 2014. Among the patients with patent bile ducts, operation duration, postoperative enteral feeding initiation time, and the time to achieve full enteral feeding were shorter in laparoscopy group. Conclusion. Laparoscopic cholangiography is safe and less time-consuming compared to laparotomy, with less postoperative burden. As early age of operation is a very important prognostic factor, laparoscopic evaluation should be an early option in work-up of the infants with prolonged jaundice with direct hyperbilirubinemia, for diagnosis/exclusion of biliary atresia. © 2016 Murat Alkan et al

Does the therapist matter? : Therapist characteristics and their relation to out-come in trauma-focused cognitive behavioral therapy for children and adolescents

Background There is a broad evidence-base for the effectiveness of Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT) in treating children and adolescents with posttraumatic stress disorder (PTSD). The effect of therapist characteristics on patient symptoms has been neglected in psychotraumatology research and necessitates further investigation. Objective This study aims to investigate the impact of therapist characteristics (gender, clinical experience and theoretical background) on posttraumatic stress symptoms (PTSS) in a heterogeneous and international sample of traumatized children and adolescents. Method Data from two RCTs on the effectiveness of TF-CBT in Norway and Germany were included, comprising N = 52 therapists (78.8% female) and N = 153 patients (72.3% female). All therapists underwent thorough training and continuous supervision in TF-CBT. The Clinician-Administered PTSD Scale for Children and Adolescents (CAPS-CA) assessed pre- and post-treatment served as the outcome variable in a linear mixed-effects model with therapists’ theoretical background, prior clinical experience and gender as independent variables, adjusted for patient gender, measurement time and country. The possibility of an interaction between therapist and patient gender was investigated subsequently. Results None of the therapist characteristics were significantly related to PTSS. There was no indication of an interaction between patient and therapist gender (p =.878). Conclusion The lack of evidence for a relationship of therapists’ theoretical orientation and clinical experience with outcome suggests that a wider dissemination of TF-CBT may be warranted. More studies with larger therapist and patient sample sizes and including only community practice are needed