Isaiah 7:10-25: The Climax of the Messianic Expectation

Is there a man called Messiah who was promised by God? Did he come? Or will he come? Isaiah gave the most straightforward prophecy — Isaiah 7:10-25 — about him. Since then, a lot of efforts have been made to figure out Who is he? However, to acknowledge Jesus as the only fulfillment of the messianic expectation, a possibly correct interpretation is not enough. One also needs a leap of faith

An Integrated Framework of Individual Acceptance of Agile Methodologies

Although systems development methodologies (SDM) are believed to help improve the software development process, the deployment of SDMs often encounters developers’ resistance. Agile methodologies, the latest batch of SDMs that are better in dealing with volatile business requirements, are likely to face the same problems since they require developers to drastically change their work habits and acquire new skills. Therefore, it is essential to identify the factors that could potentially influence individual developer’s acceptance of agile methodologies. This paper reviews the literature on the acceptance of SDMs and agile methodologies, which serves to assess current understanding in the acceptance of SDMs and agile methodologies. From this review, we identify a set of potential factors and develop a framework to guide future research in individual acceptance of agile methodologies

Design of a Satellite Cluster System in Distributed Simulation

This article presents the design and development of a satellite cluster system that supports an interfederation communication in High Level Architecture (HLA)-compliant distributed simulation. The interfederation communication enables the execution of a complex, large-scale cluster system of distributed satellites that share the dispersed data assets among satellite components collaboratively. After a brief review of the HLA bridge for interfederation communication, the authors discuss the design issues related to a satellite cluster system that provides cluster management, interfederation communication, and communication data management. They analyze system performance and scalability for centralized and decentralized configurations. The empirical results on the heterogeneous OS distributed system indicate that the satellite cluster system is effective and scalable due to the use of interfederation communication and the reduction of data transmission

Design of a Satellite Cluster System in Distributed Simulation

This article presents the design and development of a satellite cluster system that supports an interfederation communication in High Level Architecture (HLA)-compliant distributed simulation. The interfederation communication enables the execution of a complex, large-scale cluster system of distributed satellites that share the dispersed data assets among satellite components collaboratively. After a brief review of the HLA bridge for interfederation communication, the authors discuss the design issues related to a satellite cluster system that provides cluster management, interfederation communication, and communication data management. They analyze system performance and scalability for centralized and decentralized configurations. The empirical results on the heterogeneous OS distributed system indicate that the satellite cluster system is effective and scalable due to the use of interfederation communication and the reduction of data transmission

Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts

Insulin promotes the translocation of glucose transporter 4 (GLUT4) from intracellular pools to the surface of muscle and fat cells via a mechanism dependent on phosphatidylinositol (PtdIns) 3-kinase, actin cytoskeletal remodeling and the v-SNARE VAMP2. The growth factor PDGF-BB also robustly activates PtdIns 3-kinase and induces actin remodeling, raising the question of whether it uses similar mechanisms to insulin in mobilizing GLUT4. In L6 myoblasts stably expressing Myc-tagged GLUT4, neither stimulus affected the rate of GLUT4 endocytosis, confirming that they act primarily by enhancing exocytosis to increase GLUT4 at the cell surface. Although surface GLUT4myc in response to insulin peaked at 10 minutes and remained steady for 30 minutes, PDGF action was transient, peaking at 5 minutes and disappearing by 20 minutes. These GLUT4myc translocation time courses mirrored that of phosphorylation of Akt by the two stimuli. Interestingly, insulin and PDGF caused distinct manifestations of actin remodeling. Insulin induced discrete, long (>5 microm) dorsal actin structures at the cell periphery, whereas PDGF induced multiple short (70% but did not affect the PDGF response. These results suggest that insulin and PDGF rely differently on the actin cytoskeleton and on tetanus-toxin-sensitive VAMPs for mobilizing GLUT4

Review Article: A trends of Salmonella and antibiotic resistance

Salmonellosis has become a major problem in developed and developing countries. It also represents an important public health concern worldwide.  As such, due to intense interest Salmonella research has gained great concern from scientific communities as well as the general public.  The purpose of this review is to discuss the historical perspective, classification and nomenclature, antibiotic and antimicrobial definition, mechanism of antibiotic resistance, integrons and antibiotic resistance Salmonella

Review Article: A trends of Salmonella and antibiotic resistance

Salmonellosis has become a major problem in developed and developing countries. It also represents an important public health concern worldwide.  As such, due to intense interest Salmonella research has gained great concern from scientific communities as well as the general public.  The purpose of this review is to discuss the historical perspective, classification and nomenclature, antibiotic and antimicrobial definition, mechanism of antibiotic resistance, integrons and antibiotic resistance Salmonella

Determination of Leptospira borgpetersenii serovar Javanica and Leptospira interrogans serovar Bataviae as the persistent Leptospira serovars circulating in the urban rat populations in peninsular Malaysia

Background: Leptospirosis is an emerging infectious disease of global significance, and is endemic in tropical countries, including Malaysia. Over the last decade, a dramatic increase of human cases was reported; however, information on the primary vector, the rat, and the Leptospira serovars circulating among the rat population is limited. Therefore, the present study was undertaken to isolate Leptospira and characterise the serovars circulating in the urban rat populations from selected main cities in Peninsular Malaysia. Methods: Rat trappings were carried out between October 2011 to February 2014 in five urban cities which were chosen as study sites to represent different geographical locations in Peninsular Malaysia. Microscopic agglutination test (MAT) and PCR were carried out to identify the Leptospiral serogroup and determine the pathogenic status of the isolates, respectively while pulsed-field gel electrophoresis (PFGE) and random amplified polymorphic DNA (RAPD)-PCR were used to characterize the isolates. Results: Three rat species were identified from the three hundred and fifty seven rats captured with Rattus rattus, being the dominant rat species (285, 80 %) followed by Rattus norgevicus (53, 15 %) and Rattus exulans (19, 5 %). Only 39 samples (11.0 %) were positive by culture and further confirmed as pathogenic Leptospira by PCR. Significant associations were shown between host infection with locality, season, host-age and species. Based on MAT, two serogroups were identified in the population namely; L. borgpetersenii serogroup Javanica (n = 16) and L. interrogans serogroup Bataviae (n = 23). Pulsed-field gel electrophoresis (PFGE) distinguished the two serovars in the urban rat populations: L. borgpetersenii serovar Javanica (41 %), and L. interrogans serovar Bataviae (59 %). RAPD-PCR yielded 14 distinct patterns and was found to be more discriminative than PFGE. Conclusions: This study confirms two Leptospira serovars circulating among the urban rats population in Peninsular Malaysia namely; L. borgpetersenii serovar Javanica and L. interrogans serovars Bataviae. Despite the low number of isolates obtained from the rat population, this study suggests that rodent control programs and disease surveillance may help to reduce the possible risk of disease transmission