13,081 research outputs found
Current Research: Analysis of Ceramic Vessel Residues from the Washington Square Mound Site (41NA49) for Evidence of Peyote use by the Caddo in the 13th-15th centuries A.D.
In 2012, Perttula requested permission from to the Caddo Nation of Oklahoma\u27s Repatriation Committee to analyze small samples (ca. 1-2 grams of ceramic paste, or sherds ca. 1-2 square centimeters in size) from the paste of five vessels from Features 31 and 95 at the Washington Square Mound site (41NA49) (Perttula et al. 2010) in East Texas to identify residue traces of the Caddo\u27s use of peyote in the 13th-15th centuries A.D. The Caddo Nation of Oklahoma gave their permission to conduct these ceramic vessel residue studies
High temperature polymer from maleimide-acetylene terminated monomers
Thermally stable, glassy polymeric materials were prepared from maleimide-acetylene terminated monomeric materials by several methods. The monomers were heated to self-polymerize. The A-B structure of the monomer allowed it to polymerize with either bismaleimide monomers/oligomers or bis-acetylene monomers/oligomers. Copolymerization can also take place by mixing bismaleimide and bisacetylene monomers/oligomers with the maleimide-acetylene terminated monomers to yield homogenous glassy polymers
The effect of a cardiovascular risk factor education program on health behaviors of selected school age children
This study, using a quasi-experimental design, was conducted to explore the effect of a cardiovascular risk factor education program on the health behaviors of a group of fifth grade children. The following hypothesis was tested:
There will be a statistically significant improvement in self-reported health behaviors of school age children who receive a cardiovascular risk factor education program as compared to the self-reported health behaviors of those school age children who do not receive a cardiovascular risk factor education program.
One hundred and nineteen subjects, 63 in the experimental group and 56 in the control group, were tested using the researcher\u27s designed health behavior questionnaire, My Health Behaviors , before and after participation in the health education program. The program provided for the experimental group consisted of eight 45 minute sessions. The introductory and summary sessions were primarily concerned with administration of the pretest and post-test and sessions two through seven were informative sessions about high fat, high cholesterol diet, smoking and sedentary lifestyle. The program provided for the control group consisted of four 45 minute sessions; session one was concerned with introductory material and administration of the pre-test, sessions two and three were informative sessions related to general nutrition and foods high in salt and sugar, and session four was devoted to review of content as well as administration of the post—test.
Data were statistically analyzed using the paired-sample student\u27s t-test. Results of the analysis revealed a significant difference between the two sample groups at p\u3c0.01 level. The hypothesis was accepted
Crosslinked polyimides prepared from N-(3-ethynylphenyl)maleimide
The compound N-(3-ethynylphenyl)maleimide (NEPMI) was used to prepare thermally stable, glassy polyimides which did not exhibit glass transition temperatures below 500 C. NEPMI was blended with the maleimide of methylene dianiline (BMI) and heated to form the polyimide. NEPMI was also mixed with Thermid 600 R, a commercially available bisethynyl oligomeric material, and heated to form a thermally stable, glassy polyimide. Lastly, NEPMI was blended with both BMI and Thermid 600 R to form thermally stable, glassy polyimides
Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase
This research was supported by the German Academic Exchange Service (DAAD), the Wellcome Trust (TKS and WNH as Trust Senior Research fellows), the Biotechnology and Biological Science Research Council (Structural Proteomics of Rational Targets) and the European Synchrotron Radiation Facility.Background: Isoprenoid precursor synthesis via the mevalonate route in humans and pathogenic trypanosomatids is an important metabolic pathway. There is however, only limited information available on the structure and reactivity of the component enzymes in trypanosomatids. Since isoprenoid biosynthesis is essential for trypanosomatid viability and may provide new targets for therapeutic intervention it is important to characterize the pathway components. Results: Putative mevalonate kinase encoding genes from Leishmania major (LmMK) and Trypanosoma brucei (TbMK) have been cloned, over-expressed in and proteins isolated from procyclic-form T. brucei. A highly sensitive radioactive assay was developed and shows ATP-dependent phosphorylation of mevalonate. Apo and (R)-mevalonate bound crystal structures of LmMK, from a bacterial expression system, have been determined to high resolution providing, for the first time, information concerning binding of mevalonate to an MK. The mevalonate binds in a deep cavity lined by highly conserved residues. His25 is key for binding and for discrimination of (R)-over (S)-mevalonate, with the main chain amide interacting with the C3 hydroxyl group of ( R)mevalonate, and the side chain contributing, together with Val202 and Thr283, to the construction of a hydrophobic binding site for the C3 methyl substituent. The C5 hydroxyl, where phosphorylation occurs, points towards catalytic residues, Lys18 and Asp155. The activity of LmMK was significantly reduced compared to MK from other species and we were unable to obtain ATP-binding data. Comparisons with the rat MK:ATP complex were used to investigate how this substrate might bind. In LmMK, helix alpha 2 and the preceding polypeptide adopt a conformation, not seen in related kinase structures, impeding access to the nucleotide triphosphate binding site suggesting that a conformational rearrangement is required to allow ATP binding. Conclusion: Our new structural information, consistent with data on homologous enzymes allows a detailed description of how mevalonate is recognized and positioned for catalysis in MK. The mevalonate-binding site is highly conserved yet the ATP-binding site is structurally distinct in LmMK. We are unable to provide a definitive explanation for the low activity of recombinant protein isolated from a bacterial expression system compared to material isolated from procyclic-form Trypanosoma brucei.Publisher PDFPeer reviewe
What happened to the inventory overhang?
The large inventory buildup in the first half of 1997 led to media warnings of a substantially weaker economy by year's end. The authors examine the rationale for these warnings, and argue that inventory accumulation is an unreliable predictor of future economic strength.Inventories ; Business cycles
Soluble aromatic polyimides for film and coating applications
Linear all-aromatic polyimides have been synthesized and characterized which show much potential as films and coatings for electronic applications. Structure-property relations with regard to methods for obtaining solubility of fully imidized polymers will be discussed. Methods used to obtain solubility include variation of polymer molecular structure, variation of isomerism of the diamine monomer, modification of cure time/temperature and atmosphere. Other properties of soluble polyimides will be presented which include glass transition temperatures, thermooxidative stabilities, UV-visible spectra, and refractive indices
Damping of Electron Density Structures and Implications for Interstellar Scintillation
The forms of electron density structures in kinetic Alfven wave turbulence
are studied in connection with scintillation. The focus is on small scales cm where the Kinetic Alfv\'en wave (KAW) regime is active in
the interstellar medium. MHD turbulence converts to a KAW cascade, starting at
10 times the ion gyroradius and continuing to smaller scales. These scales are
inferred to dominate scintillation in the theory of Boldyrev et al. From
numerical solutions of a decaying kinetic Alfv\'en wave turbulence model,
structure morphology reveals two types of localized structures, filaments and
sheets, and shows that they arise in different regimes of resistive and
diffusive damping. Minimal resistive damping yields localized current filaments
that form out of Gaussian-distributed initial conditions. When resistive
damping is large relative to diffusive damping, sheet-like structures form. In
the filamentary regime, each filament is associated with a non-localized
magnetic and density structure, circularly symmetric in cross section. Density
and magnetic fields have Gaussian statistics (as inferred from Gaussian-valued
kurtosis) while density gradients are strongly non-Gaussian, more so than
current. This enhancement of non-Gaussian statistics in a derivative field is
expected since gradient operations enhance small-scale fluctuations. The
enhancement of density gradient kurtosis over current kurtosis is not obvious,
yet it suggests that modest fluctuation levels in electron density may yield
large scintillation events during pulsar signal propagation in the interstellar
medium. In the sheet regime the same statistical observations hold, despite the
absence of localized filamentary structures. Probability density functions are
constructed from statistical ensembles in both regimes, showing clear formation
of long, highly non-Gaussian tails
Polyimides prepared from 3,5-diamino benzo trifluoride
High performance, thermooxidatively stable polyimides are prepared by reacting aromatic diamines with pendant trifluoromethyl groups and dianhydrides in an amide solvent to form a poly(amic acid), followed by cyclizing the poly(amic acid) to form the corresponding polyimide
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