Five-year study assessing the clinical utility of anti-Müllerian hormone measurements in reproductive-age women with cancer

An important discussion point before chemotherapy is ovarian toxicity, a side-effect that profoundly affects young women with cancer. Their quality of life after successful treatment, including the ability to conceive, is a major concern. We asked whether serum anti-Müllerian hormone (AMH) measurements before chemotherapy for two most common malignancies are predictive of long-term changes in ovarian reserve? A prospective cohort study measured serum AMH in 66 young women with lymphoma and breast cancer, before and at 1 year and 5 years after chemotherapy, compared with 124 healthy volunteers of the same age range (18-43 years). Contemporaneously, patients reported their menses and live births during 5-year follow-up. After adjustment for age, serum AMH was 1.4 times higher (95% CI 1.1 to 1.9; P < 0.02) in healthy volunteers than in cancer patients before chemotherapy. A strong correlation was observed between baseline and 5-year AMH in the breast cancer group (P < 0.001, regression coefficient = 0.58, 95% CI 0.29 to 0.89). No significant association was found between presence of menses at 5 years and serum AMH at baseline (likelihood ratio test from logistics regression analysis). Reproductive-age women with malignancy have lower serum AMH than healthy controls even before starting chemotherapy. Pre-chemotherapy AMH was significantly associated with long-term ovarian function in women with breast cancer. At key time points, AMH measurements could be used as a reproductive health advisory tool for young women with cancer. Our results highlight the unsuitability of return of menstruation as a clinical indicator of ovarian reserve after chemotherapy. [Abstract copyright: Crown Copyright © 2019. Published by Elsevier Ltd. All rights reserved.

Pion-Lambda-Sigma Coupling Extracted from Hyperonic Atoms

The latest measurements of the atomic level width in Sigma-hyperonic Pb atom offer the most accurate datum in the region of low-energy Sigma-hyperon physics. Atomic widths are due to the conversion of Sigma-nucleon into Lambda-nucleon. In high angular momentum states this conversion is dominated by the one-pion exchange. A joint analysis of the data of the scattering of negative-Sigma on proton converting into a Lambda and a neutron and of the atomic widths allows to extract a pseudovector pion-hyperon-Sigma coupling constant of 0.048 with a statistical error of +-0.005 and a systematic one of +-0.004. This corresponds to a pseudoscalar coupling constant of 13.3 with a statistical uncertainty of 1.4 and a systematic one of 1.1.Comment: 12 pages, 1 figure, Use of Revtex.st

Study of the Sigma-nucleus potential by the (pi^-,K^+) reaction on medium-to-heavy nuclear targets

In order to study the Sigma-nucleus optical potential, we measured inclusive (pi^-,K^+) spectra on medium-to-heavy nuclear targets: CH_2, Si, Ni, In and Bi. The CH_2 target was used to calibrate the excitation energy scale by using the elementary process p + pi^- -> K^+ + Sigma^-, where the C spectrum was also extracted. The calibration was done with +-0.1 MeV precision. The angular distribution of the elementary cross section was measured, and agreed well with the previous bubble chamber data, but with better statistics, and the magnitudes of the cross sections of the measured inclusive (pi^-,K^+) spectra were also well calibrated. All of the inclusive spectra were found to be similar in shape at a region near to the Sigma^- binding energy threshold, showing a weak mass-number dependence on the magnitude of the cross section. The measured spectra were compared with a theoretical calculation performed within the framework of the Distorted Wave Impulse Approximation (DWIA). It has been demonstrated that a strongly repulsive \sig-nucleus potential with a non-zero size of the imaginary part is required to reproduce the shape of the measured spectra.Comment: 21 pages, 24 figures, submitted to PR

Analyser of images assisted by neural network, searching for diagnostically important fetures in radionuclide cardiac and renal dynamic studies

Przedstawiono zastosowanie sztucznych sieci neuronowych do automatycznej analizy dynamicznych badań scyntygraficznych serca i nerek. Zmiany radioaktywne w czasie, dla każdego piksela pola obrazowego, były oceniane przez odpowiednio wytrenowane sieci. Proponowana metoda umożliwia łatwą i szybką analize serii scyntygramów poprzez wyswietlanie pojedynczych obrazów ukazujacych regiony o róznym stopniu patologicznego przepływu krwi w wyniku istnienia przecieku lewo-prawego lub miejsca prawidłowej i upośledzonej funkcji nerek.The ability of the artificial neural network (ANNs) to automatic analysing either the cardiac or renal sequential scintigrams was presented. The time/activity curves, for each pixel were evaluated by appropriate trained ANNs. The proposed method permits an easy and fast analysis of series of scintigrams, by mapping results either as the regions of different degrees of pathological blood flow because of left-to-right shunt or as the places in kindey of normal and abnormal renal function

University Social Responsibility – Good Practices of Polish Higher Education Institutions

All organizations, including Higher Education Institutions (HEIs), should be socially responsible. Therefore, the article aims to answer the following research questions: How are the principles of social responsibility implemented by Polish HEIs? Through what good practices are they manifested? What formal national regulations support these activities? To answer those questions, the principles of the Declaration of University Social Responsibility and of good practices implemented by 23 universities, the first signatories of this Declaration, were reviewed. The applied research method has incorporated the analysis of the literature on the subject, documents and websites of the above 23 universities. The study presents the essence of university social responsibility and the special role of universities in promoting and implementing the principles of sustainable development and social responsibility. The activities of the Polish public administration in partnership with the representatives of HEIs, businesses, NGOs which led to the creation of the Declaration of USR were outlined. Examples of good practices applied by the examined universities and the ensuing conclusions were briefly discussed