Electrical characterization of the junctions P+ N by C-V technique

Technique CV exploits measurement in mode of small signals for a relatively high frequency of the capacity of a junction metal-semi driver or a junction P+ NR (or PN+ polarized in reverse by a tension V R The experimental analysis of this technique makes it possible to determine some electric properties of the junctions P+ N or Schottky. We describe here, the method used and we expose then the results obtained by this technique on diodes containing silicon (Si).Technique CV exploits measurement in mode of small signals for a relatively high frequency of the capacity of a junction metal-semi driver or a junction P+ NR (or PN+ polarized in reverse by a tension V R The experimental analysis of this technique makes it possible to determine some electric properties of the junctions P+ N or Schottky. We describe here, the method used and we expose then the results obtained by this technique on diodes containing silicon (Si)

Inhibition of Y1 receptor signaling improves islet transplant outcome

Failure to secrete sufficient quantities of insulin is a pathological feature of type-1 and type-2 diabetes, and also reduces the success of islet cell transplantation. Here we demonstrate that Y1 receptor signaling inhibits insulin release in β-cells, and show that this can be pharmacologically exploited to boost insulin secretion. Transplanting islets with Y1 receptor deficiency accelerates the normalization of hyperglycemia in chemically induced diabetic recipient mice, which can also be achieved by short-term pharmacological blockade of Y1 receptors in transplanted mouse and human islets. Furthermore, treatment of non-obese diabetic mice with a Y1 receptor antagonist delays the onset of diabetes. Mechanistically, Y1 receptor signaling inhibits the production of cAMP in islets, which via CREB mediated pathways results in the down-regulation of several key enzymes in glycolysis and ATP production. Thus, manipulating Y1 receptor signaling in β-cells offers a unique therapeutic opportunity for correcting insulin deficiency as it occurs in the pathological state of type-1 diabetes as well as during islet transplantation.Islet transplantation is considered one of the potential treatments for T1DM but limited islet survival and their impaired function pose limitations to this approach. Here Loh et al. show that the Y1 receptor is expressed in β- cells and inhibition of its signalling, both genetic and pharmacological, improves mouse and human islet function.info:eu-repo/semantics/publishe

Trans effect and inverse trans effect in MLX5 complexes (M=Mo, U; L=O, S; X=Cl, Br): A rationalization within density functional theory study

International audienc

Kinetics and Mechanism of the Water-Gas Shift Reaction Over Platinum Supported Catalysts

INGENIERIE+KRA:OTH:YSCNon

Effet du Kétoconazole sur le temps d’immobilité et la réponse immunitaire au cours de la nage forcée chez le rat Wistar

La depression est installée suite aux perturbations des activités de l’axe corticotrope et du système immunitaire. L’objectif de cette étude est d'explorer les effets du ketoconazole (KTCZ), un dérivé d'imidazole, inhibiteur de stréroїdogénèse surrénalienne, sur les variations du nombre de globules blancs totaux et des pourcentages des sous-populations leucocytaires, au cours de la nage forcée chez le rat, modèle animal de dépression. Des cathéters ont été implantés sous anesthésie générale dans la veine jugulaire droite et des prises de sang (0.2 ml) ont été réalisées à des intervalles de temps de 15 minutes, alors que les animaux se comportaient librement pendant les expériences. Le degré d’anxiété et de l’activité locomotrice des rats ont été mesurés au labyrinthe en croix surélevé. L'amélioration des comportements des rats traités au KTCZ suggérerait que le corticostérone soit le médiateur le plus important dans la pathogénie de la dépression.Mots clés : nage forcée ; corticostérone ; cytokines