An experimental study to evaluate the antidotal activity of Neeli Moola (Indigofera tinctoria) Kalka w.s.r to haematological parameters in Vatsanabha (Aconitum ferox ) induced toxicity

Background: Vatsanabha is a potent cardiac poison comes under the category of Mahavisha with its main active principles aconitine, picraconine and pseudaconine. In the literatures there are descriptions about toxicants and in some traditional Malayalam textbooks antidotes has been explained under the concept “Prathyoushadha”. Neeli Moola has been mentioned as a Prathyoushadha for Vatsanabha poisoning in a renowned textbook ‘Visha Vaidya Jyotsnika’. Hence to evaluate the antidotal activity in Vatsanabha poisoning, Neeli Moola Kalka has been used and the haematological parameters were analyzed to screen the results. Methods: Wistar strain albino rats were used in this study which were divided into 3 groups, normal control, toxic control and the test drug group. The duration of the study was 28 days .The data generated was mentioned as Mean±SEM. Difference among the groups was assessed by employing one way ANOVA followed by Dunnet’s multiple ‘t’ test. Results: Reversible action has been observed after the administration of Neeli Moola Kalka in the hematological parameters which has shown toxicity changes due to administration of Vatsanabha. Conclusion: Neeli Moola Kalka is having mild to moderate antidote effect in Vatsanbha induced toxicity

Seeing-Induced Errors in Solar Doppler Velocity Measurements

Imaging systems based on a narrow-band tunable filter are used to obtain Doppler velocity maps of solar features. These velocity maps are created by taking the difference between the blue- and red-wing intensity images of a chosen spectral line. This method has the inherent assumption that these two images are obtained under identical conditions. With the dynamical nature of the solar features as well as the Earth's atmosphere, systematic errors can be introduced in such measurements. In this paper, a quantitative estimate of the errors introduced due to variable seeing conditions for ground-based observations is simulated and compared with real observational data for identifying their reliability. It is shown, under such conditions, that there is a strong cross-talk from the total intensity to the velocity estimates. These spurious velocities are larger in magnitude for the umbral regions compared to the penumbra or quiet-sun regions surrounding the sunspots. The variable seeing can induce spurious velocities up to about 1 km/s It is also shown that adaptive optics, in general, helps in minimising this effect.Comment: 14 page

Vegetable Pigeonpea - a High Protein Food for all Ages (Vegetable pigeonpea recipes) Information Bulletin No-83

Most of the food proteins for vegetarians in the semi-arid tropics are derived from legumes that are generally grown under low input and risk-prone marginal environments with repeatedly low and unstable yields. At present, the protein availability in such areas is less than one-third of its normal requirement and with the continuously growing population and stagnation of yield, the protein availability to the masses is likely to decline further. Since the food production balance in most countries will always remain in favor of cereals, the issue of protein availability assumes a greater significance from the point of view of nutrition for the poor. This publication in two books (Part I – The science behind the scenes; Part II – Vegetable pigeonpea recipes) covers both scientific and nutritional aspects of the crop and provides recipes for tasty pigeonpea dishes

Vegetable Pigeonpea – a High Protein Food for all Ages

Most of the food proteins for vegetarians in the semi-arid tropics are derived from legumes that are generally grown under low input and risk-prone marginal environments with repeatedly low and unstable yields. At present, the protein availability in such areas is less than one-third of its normal requirement and with the continuously growing population and stagnation of yield, the protein availability to the masses is likely to decline further. Since the food production balance in most countries will always remain in favor of cereals, the issue of protein availability assumes a greater significance from the point of view of nutrition for the poor. This publication in two books (Part I – The science behind the scenes; Part II – Vegetable pigeonpea recipes) covers both scientific and nutritional aspects of the crop and provides recipes for tasty pigeonpea dishes

Ergonomic Risk Assessment and Fatigue Analysis During Manual Lifting Tasks in Farming Activities

Introduction: Farming is a physically demanding occupation that puts farmers at risk of musculoskeletal disorders, particularly when frequently performing activities like heavy lifting, which strains the lower back muscles. The present study aimed to assess the ergonomic risk and fatigue during manual lifting tasks pertaining to farming activities. Methods: A study was performed on 20 farmers to analyze the ergonomic risks associated with load lifting through the estimation of the Recommended Weight Limit and Lifting Index using the revised NIOSH lifting equation. The low back compression forces of the participants were estimated using the 3DSSPP software. Surface electromyography was employed to analyze the onset of muscle fatigue during the lifting activity. Results: The results of the study showed a 111.12% increase in the recommended weight limit, a 52.77% reduction in lifting index, and a 28.15% reduction in the low back compression forces for the redesigned lifting technique. The average low-back compression force for the redesigned technique was observed to be well below the back compression design limit of 770 lb. A reduction in the slope of the RMS voltage regression line by 60% and a reduction of 50.23% in the peak spectral power of the sEMG signal, accompanied by a shift in the peak spectral power towards higher frequency region indicated delayed onset of fatigue for the redesigned technique. Conclusion: The outcomes of the study indicated that the ergonomic redesign of the lifting task could significantly reduce the lifting index and alleviate the spinal compression forces well within the back-compression design limit. The redesign was also found to delay the onset of fatigue in the erector spinae muscles

Network Geometry and Complexity

(28 pages, 11 figures)Higher order networks are able to characterize data as different as functional brain networks, protein interaction networks and social networks beyond the framework of pairwise interactions. Most notably higher order networks include simplicial complexes formed not only by nodes and links but also by triangles, tetrahedra, etc. More in general, higher-order networks can be cell-complexes formed by gluing convex polytopes along their faces. Interestingly, higher order networks have a natural geometric interpretation and therefore constitute a natural way to explore the discrete network geometry of complex networks. Here we investigate the rich interplay between emergent network geometry of higher order networks and their complexity in the framework of a non-equilibrium model called Network Geometry with Flavor. This model, originally proposed for capturing the evolution of simplicial complexes, is here extended to cell-complexes formed by subsequently gluing different copies of an arbitrary regular polytope. We reveal the interplay between complexity and geometry of the higher order networks generated by the model by studying the emergent community structure and the degree distribution as a function of the regular polytope forming its building blocks. Additionally, we discuss the underlying hyperbolic nature of the emergent geometry and we relate the spectral dimension of the higher-order network to the dimension and nature of its building blocks

Nations within a nation: variations in epidemiological transition across the states of India, 1990–2016 in the Global Burden of Disease Study

18% of the world's population lives in India, and many states of India have populations similar to those of large countries. Action to effectively improve population health in India requires availability of reliable and comprehensive state-level estimates of disease burden and risk factors over time. Such comprehensive estimates have not been available so far for all major diseases and risk factors. Thus, we aimed to estimate the disease burden and risk factors in every state of India as part of the Global Burden of Disease (GBD) Study 2016