Effect of mebendazole on fibrosarcoma in hamsters

Purpose: To investigate the effect of mebendazole on an in vivo solid tumor model of fibrosarcoma in hamsters.Methods: 24 Syrian golden hamsters of both sexes with the approximate body  weight of 100g were randomly distributed in 2 experimental and 2 control groups, with 6 animals in each group. BHK-21/C13 cells (2 x 106) in 1 mL Glasgow Minimum Essential Medium (GMEM) were injected subcutaneously into the back of each animal in 3 groups. The experimental groups were treated with mebendazole  (460 mg/kg) via a gastric tube on a daily basis, immediately after tumor inoculation. In addition, one experimental group received deoxycholic acid 20 mg/kg once a day. After 2 weeks, when the tumors were approximately 1 - 2 cm in the control group, all the animals were sacrificed, and their blood collected for laboratory analysis. The tumors were excised, their weight and diameters measured, and the volumes  calculated. The tumor samples were histopathologically assessed and the main organs toxicologically analyzed. Images were taken and processed by an imaging software, and Ki-67-positive cells in the tumor samples were quantified.Results: Mebendazole diminished tumor mitosis from 18.5 ± 3.02 to 13.5 ± 3.45 (p < 0.05), vasculature and tissue penetration, and increased necroses in tumor  slices. Tumor volume and weight were insignificantly attenuated. Toxicity was not observed.Conclusion: Mebendazole might be an effective non-toxic agent in sarcoma therapy.Keywords: Mebendazole, Hamsters, BHK-21/C13 cells, Fibrosarcoma therapy,  Tumor mitosi

Application of a widely-used tropical anti-worm agent, mebendazole, in modern oncology

Although clinical trials have not been completed, it has already been confirmed that mebendazole, a well-known anti-parasitic drug widely used in the tropical areas, inhibits cancer cell growth. Preclinical studies show that mebendazole notably impedes the growth of malignant and metastatic tumors such as osteosarcoma and soft tissue sarcoma, melanoma, carcinoma (lung, colorectal, breast, ovarian, hepatocellular and adrenocortical), acute myeloid leukaemia, glioblastoma multiforme and  meduloblastoma. Mebendazole can induce the depolymerization of microtubules in neoplasms and newly formed vasculature, stopping tumor growth and neoangiogenesis, along with other proposed mechanisms of action.Keywords: Anthelmintic, Mebendazole, Cancer treatment, Antimicrotubullar effect, Antineoangiogenesi

Mesoscopic Behavior Near a Two-Dimensional Metal-Insulator Transition

We study conductance fluctuations in a two-dimensional electron gas as a function of chemical potential (or gate voltage) from the strongly insulating to the metallic regime. Power spectra of the fluctuations decay with two distinct exponents (1/v_l and 1/v_h). For conductivity $\sigma\sim 0.1 e^{2}/h$, we find a third exponent (1/v_i) in the shortest samples, and non-monotonic dependence of v_i and v_l on \sigma. We study the dependence of v_i, v_l, v_h, and the variances of corresponding fluctuations on \sigma, sample size, and temperature. The anomalies near $\sigma\simeq 0.1 e^{2}/h$ indicate that the dielectric response and screening length are critically behaved, i.e. that Coulomb correlations dominate the physics.Comment: Revised according to referee remark

Streamlining collection of training samples for object detection and classification in video

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Canonical approach to 2D induced gravity

Using canonical method the Liouville theory has been obtained as a gravitational Wess-Zumino action of the Polyakov string. From this approach it is clear that the form of the Liouville action is the consequence of the bosonic representation of the Virasoro algebra, and that the coefficient in front of the action is proportional to the central charge and measures the quantum braking of the classical symmetry.Comment: RevTeX, 19 page

Transfer of Cs-134 and Cs-137 from soils to plants in cultivated and uncultivated soils in different regions of Yugoslavia

10th international congress of the International Radiation Protection Association; May 14-19, 2000; Hiroshima, Japa

Raman Response in Antiferromagnetic Two-Leg S=1/2 Heisenberg Ladders

The Raman response in the antiferromagnetic 2-leg S=1/2 Heisenberg ladder is calculated for various couplings by continuous unitary transformations. For leg couplings above 80% of the rung coupling a characteristic 2-peak structure occurs with a point of zero intensity within the continuum. Experimental data for CaV_2O_5 and La_yCa_(14-y)Cu_24O_41 are analyzed and the coupling constants are determined. Evidence is found that the Heisenberg model is not sufficient to describe cuprate ladders. We argue that a cyclic exchange term is the appropriate extension.Comment: 4 pages with 4 figures include

Metal fume fever

Prikazana su dva slučaja cinkove groznice s osvrtom na etiopatogenezu, kliničku sliku i terapiju tog oboljenja. Dijagnoza je postavljena na osnovu anamneznih podataka i kliničke slike. Ukazano je na potrebu rigoroznije primene preventivnih mera, budući da je oboljenje najčešće posledica njihovog neprimenjivanja.Two cases of metal fume fever are described. The etiopathogenesis, clinical picture and therapy of the disease are dealt with. The diagnosis is based on anamnestic data and clinical picture. The necessity for strict preventive measures is pointed out, as the disease is mainly due to the lack of prophylaxis