Independent Orbiter Assessment (IOA): Analysis of the DPS subsystem

The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis/Critical Items List (FMEA/CIL) is presented. The IOA approach features a top-down analysis of the hardware to independently determine failure modes, criticality, and potential critical items. The independent analysis results corresponding to the Orbiter Data Processing System (DPS) hardware are documented. The DPS hardware is required for performing critical functions of data acquisition, data manipulation, data display, and data transfer throughout the Orbiter. Specifically, the DPS hardware consists of the following components: Multiplexer/Demultiplexer (MDM); General Purpose Computer (GPC); Multifunction CRT Display System (MCDS); Data Buses and Data Bus Couplers (DBC); Data Bus Isolation Amplifiers (DBIA); Mass Memory Unit (MMU); and Engine Interface Unit (EIU). The IOA analysis process utilized available DPS hardware drawings and schematics for defining hardware assemblies, components, and hardware items. Each level of hardware was evaluated and analyzed for possible failure modes and effects. Criticality was assigned based upon the severity of the effect for each failure mode. Due to the extensive redundancy built into the DPS the number of critical items are few. Those identified resulted from premature operation and erroneous output of the GPCs

Independent Orbiter Assessment (IOA): Analysis of the guidance, navigation, and control subsystem

The results of the Independent Orbiter Assessment (IOA) of the Failure Modes and Effects Analysis (FMEA) and Critical Items List (CIL) is presented. The IOA approach features a top-down analysis of the hardware to determine failure modes, criticality, and potential critical items. To preserve independence, this analysis was accomplished without reliance upon the results contained within the NASA FMEA/CIL documentation. The independent analysis results corresponding to the Orbiter Guidance, Navigation, and Control (GNC) Subsystem hardware are documented. The function of the GNC hardware is to respond to guidance, navigation, and control software commands to effect vehicle control and to provide sensor and controller data to GNC software. Some of the GNC hardware for which failure modes analysis was performed includes: hand controllers; Rudder Pedal Transducer Assembly (RPTA); Speed Brake Thrust Controller (SBTC); Inertial Measurement Unit (IMU); Star Tracker (ST); Crew Optical Alignment Site (COAS); Air Data Transducer Assembly (ADTA); Rate Gyro Assemblies; Accelerometer Assembly (AA); Aerosurface Servo Amplifier (ASA); and Ascent Thrust Vector Control (ATVC). The IOA analysis process utilized available GNC hardware drawings, workbooks, specifications, schematics, and systems briefs for defining hardware assemblies, components, and circuits. Each hardware item was evaluated and analyzed for possible failure modes and effects. Criticality was assigned based upon the severity of the effect for each failure mode

Discovery of a New Deeply Eclipsing SU UMa-Type Dwarf Nova, IY UMa (= TmzV85)

We discovered a new deeply eclipsing SU UMa-type dwarf nova, IY UMa, which experienced a superoutburst in 2000 January. Our monitoring revealed two distinct outbursts, which suggest a superoutburst interval of ~800 d, or its half, and an outburst amplitude of 5.4 mag. From time-series photometry during the superoutburst, we determined a superhump and orbital period of 0.07588 d and 0.0739132 d, respectively.Comment: 5 pages, 3 figures, accepted by PASJ lette

HS 2325+8205 - an ideal laboratory for accretion disk physics

We identify HS 2325+8205 as an eclipsing, frequently outbursting dwarf nova with an orbital period of 279.841731(5) min. Spectroscopic observations are used to derive the radial velocity curve of the secondary star from absorption features and also from the H-alpha emission lines, originating from the accretion disc, yielding K_secondary = K_abs = 237 +- 28 km/s and K_emn = 145 +- 9 km/s respectively. The distance to the system is calculated to be 400 (+200, -140) pc. A photometric monitoring campaign reveals an outburst recurrence time of 12-14 d, The combination of magnitude range (17-14 mag), high declination, eclipsing nature and frequency of outbursts makes HS 2325+8205 the ideal system for "real-time" studies of the accretion disc evolution and behavior in dwarf nova outbursts.Comment: 20 pages, 7 figures. Accepted for Publications of the Astronomical Society of the Pacifi

Magnetic Reconnection Triggered by the Parker Instability in the Galaxy: Two-Dimensional Numerical Magnetohydrodynamic Simulations and Application to the Origin of X-Ray Gas in the Galactic Halo

We propose the Galactic flare model for the origin of the X-ray gas in the Galactic halo. For this purpose, we examine the magnetic reconnection triggered by Parker instability (magnetic buoyancy instability), by performing the two-dimensional resistive numerical magnetohydrodynamic simulations. As a result of numerical simulations, the system evolves as following phases: Parker instability occurs in the Galactic disk. In the nonlinear phase of Parker instability, the magnetic loop inflates from the Galactic disk into the Galactic halo, and collides with the anti-parallel magnetic field, so that the current sheets are created in the Galactic halo. The tearing instability occurs, and creates the plasmoids (magnetic islands). Just after the plasmoid ejection, further current-sheet thinning occurs in the sheet, and the anomalous resistivity sets in. Petschek reconnection starts, and heats the gas quickly in the Galactic halo. It also creates the slow and fast shock regions in the Galactic halo. The magnetic field ($B\sim 3 \mu$G), for example, can heat the gas ($n\sim 10^{-3}$ cm$^{-3}$) to temperature of $\sim 10^6$ K via the reconnection in the Galactic halo. The gas is accelerated to Alfv\'en velocity ($\sim 300$ km s$^{-1}$). Such high velocity jets are the evidence of the Galactic flare model we present in this paper, if the Doppler shift of the bipolar jet is detected in the Galactic halo. Full size figures are available at http://www.kwasan.kyoto-u.ac.jp/~tanuma/study/ApJ2002/ApJ2002.htmlComment: 13 pages, 12 figures, uses emulateapj.sty, accepted by Ap

Dynamic interaction of PTP mu with multiple cadherins in vivo

There is a growing body of evidence to implicate reversible tyrosine phosphorylation as an important mechanism in the control of the adhesive function of cadherins. We previously demonstrated that the receptor protein tyrosine phosphatase PTP mu associates with the cadherin-catenin complex in various tissues and cells and, therefore, may be a component of such a regulatory mechanism (Brady-Kalnay, S.M., D.L. Rimm, and N.K. Tonks. 1995. J. Cell Biol. 130:977-986). In this study, we present further characterization of this interaction using a variety of systems. We observed that PTP mu interacted with N-cadherin, E-cadherin, and cadherin-4 (also called R-cadherin) in extracts of rat lung. We observed a direct interaction between PTP mu, and E-cadherin after coexpression in Sf9 cells. In WC5 cells, which express a temperature-sensitive mutant form of v-Src, the complex between PTP mu and E-cadherin was dynamic, and conditions that resulted in tyrosine phosphorylation of E-cadherin were associated with dissociation of PTP mu from the complex. Furthermore, we have demonstrated that the COOH-terminal 38 residues of the cytoplasmic segment of E-cadherin was required for association with PTP mu in WC5 cells. Zondag et al. (Zondag, G., W. Moolenaar, and M. Gebbink. 1996. J. Cell Biol. 134: 1513-1517) have asserted that the association we observed between PTP mu and the cadherin-catenin complex in immunoprecipitates of the phosphatase arises from nonspecific cross-reactivity between BK2, our antibody to PTP mu, and cadherins. In this study we have confirmed our initial observation and demonstrated the presence of cadherin in immunoprecipitates of PTP mu. obtained with three antibodies that recognize distinct epitopes in the phosphatase. In addition, we have demonstrated directly that the anti-PTP mu antibody BK2 that we used initially did not cross-react with cadherin. Our data reinforce the observation of an interaction between PTP mu, and E-cadherin in vitro and in vivo, further emphasizing the potential importance of reversible tyrosine phosphorylation in regulating cadherin function

High-redshift X-ray properties of the haloes of simulated disc galaxies

X-ray luminosities and surface brightness profiles of the hot gas haloes of simulated disc galaxies at redshifts z=0-2 are presented. The galaxies are extracted from fully cosmological simulations and correspond in mass to the Milky Way. We find that the bolometric X-ray luminosities of the haloes decrease by a factor 4-10 from z~1 to z~0, reflecting the decrease in the rate at which hot halo gas cools out on to the disc. At all redshifts, most of the emission is found to originate within 10-15 kpc of the disc. When combined with models in which the evolution of disc X-ray luminosity is dominated by X-ray binaries, the predicted halo luminosities at z~1 show good agreement with constraints from spiral galaxies in Chandra Deep Field data. There is an indication that haloes with a metal abundance of 0.3 solar overpredict observed X-ray luminosities at z~1, suggesting that halo metallicities are lower than this value. Prospects for direct detection of the haloes of Milky Way-sized galaxies with current and future X-ray instrumentation are discussed. It is found that XEUS should be able to single out the halo emission of highly inclined Milky Way-sized disc galaxies out to approximately z=0.3. For such galaxies in this redshift interval, we estimate a lower limit to the surface density of detectable haloes on the sky of ~10 deg^(-2). More generally, owing to their luminosity evolution, the optimum redshifts at which to observe such haloes could be 0.5<z<1, depending on their assembly history.Comment: 9 pages, 4 figures, minor corrections to conform to version accepted to MNRA

Two-Dimensional MHD Numerical Simulations of Magnetic Reconnection Triggered by A Supernova Shock in Interstellar Medium, Generation of X-Ray Gas in Galaxy

We examine the magnetic reconnection triggered by a supernova (or a point explosion) in interstellar medium, by performing two-dimensional resistive magnetohydrodynamic (MHD) numerical simulations with high spatial resolution. We found that the magnetic reconnection starts long after a supernova shock (fast-mode MHD shock) passes a current sheet. The current sheet evolves as follows: (i) Tearing-mode instability is excited by the supernova shock, and the current sheet becomes thin in its nonlinear stage. (ii) The current-sheet thinning is saturated when the current-sheet thickness becomes comparable to that of Sweet-Parker current sheet. After that, Sweet-Parker type reconnection starts, and the current-sheet length increases. (iii) ``Secondary tearing-mode instability'' occurs in the thin Sweet-Parker current sheet. (iv) As a result, further current-sheet thinning occurs and anomalous resistivity sets in, because gas density decreases in the current sheet. Petschek type reconnection starts and heats interstellar gas. Magnetic energy is released quickly while magnetic islands are moving in the current sheet during Petschek type reconnection. The released magnetic energy is determined by the interstellar magnetic field strength, not energy of initial explosion nor distance to explosion. We suggest that magnetic reconnection is a possible mechanism to generate X-ray gas in Galaxy.Comment: 17 pages using emulateapj.sty, 24 figures (4colors), submitted to ApJ, mpeg simulations and psfiles are available at http://stesun8.stelab.nagoya-u.ac.jp/~tanuma/apj2000/apj2000.htm

Large neutral amino acids in the treatment of PKU: from theory to practice

Notwithstanding the success of the traditional dietary phenylalanine restriction treatment in phenylketonuria (PKU), the use of large neutral amino acid (LNAA) supplementation rather than phenylalanine restriction has been suggested. This treatment modality deserves attention as it might improve cognitive outcome and quality of life in patients with PKU. Following various theories about the pathogenesis of cognitive dysfunction in PKU, LNAA supplementation may have multiple treatment targets: a specific reduction in brain phenylalanine concentrations, a reduction in blood (and consequently brain) phenylalanine concentrations, an increase in brain neurotransmitter concentrations, and an increase in brain essential amino acid concentrations. These treatment targets imply different treatment regimes. This review summarizes the treatment targets and the treatment regimens of LNAA supplementation and discusses the differences in LNAA intake between the classical dietary phenylalanine-restricted diet and several LNAA treatment forms