Rights management technologies: A good choice for securing electronic healthrecords?

Advances in healthcare IT bring new concerns with respect to privacy and security. Security critical patient data no longer resides on mainframes physically isolated within an organization, where physical security measures can be taken to defend the data and the system. Modern solutions are heading towards open, interconnected environments where storage outsourcing and operations on untrusted servers happen frequently. In order to allow secure sharing of health records between different healthcare providers, Rights Management Techniques facilitating a datacentric protection model can be employed: data is cryptographically protected and allowed to be outsourced or even freely float on the network. Rather than relying on different networks to provide confidentiality, integrity and authenticity, data is protected at the end points of the communication. In this paper we compare Enterprise/Digital Rights Management with traditional security techniques and discuss how Rights Management can be applied to secure Electronic Health Records

Water and salt transport in plaster/substrate systems

The transport of salt and water during drying has been studied in systems consisting of a substrate covered with either one or two plaster layers. The drying behaviour of these systems was modelled with invasion percolation (IP) algorithms. The model outcomes were compared with experimental results obtained with Nuclear Magnetic Resonance (NMR). It was found that drying behaviour of the plaster layers was strongly influenced by the properties of the substrate. When the substrate has the widest pores, the plaster layers stay wet while the substrate dries out. As a consequence most salt, present in the substrate, moves to the plaster layers and accumulates at the external surface. In the case that the substrate has the smallest pores, the plaster layers dry out first. In this case salts also crystallize in the substrate. Further we have tried to make an accumulating plaster system consisting of two layers on top of a substrate, which would function purely on the basis of differences in pore sizes between the layers. The drying behaviour in the presence of pure water was as predicted by the model. However, in the case of a salt solution the salt modified the drying behaviour such that the accumulation properties of the system were reduced. Therefore, we conclude that for transporting systems tuning the pore-sizes of the layers suffices, but for accumulating systems it seems that additives , for example water repellents, have to be used

An automatic visual analysis system for tennis

This article presents a novel video analysis system for coaching tennis players of all levels, which uses computer vision algorithms to automatically edit and index tennis videos into meaningful annotations. Existing tennis coaching software lacks the ability to automatically index a tennis match into key events, and therefore, a coach who uses existing software is burdened with time-consuming manual video editing. This work aims to explore the effectiveness of a system to automatically detect tennis events. A secondary aim of this work is to explore the bene- fits coaches experience in using an event retrieval system to retrieve the automatically indexed events. It was found that automatic event detection can significantly improve the experience of using video feedback as part of an instructional coaching session. In addition to the automatic detection of key tennis events, player and ball movements are automati- cally tracked throughout an entire match and this wealth of data allows users to find interesting patterns in play. Player and ball movement information are integrated with the automatically detected tennis events, and coaches can query the data to retrieve relevant key points during a match or analyse player patterns that need attention. This coaching software system allows coaches to build advanced queries, which cannot be facilitated with existing video coaching solutions, without tedious manual indexing. This article proves that the event detection algorithms in this work can detect the main events in tennis with an average precision and recall of 0.84 and 0.86, respectively, and can typically eliminate man- ual indexing of key tennis events

In Vitro Aging of Human Skin Fibroblasts: Age-Dependent Changes in 4-Hydroxynonenal Metabolism

Evidence suggests that the increased production of free radicals and reactive oxygen species lead to cellular aging. One of the consequences is lipid peroxidation generating reactive aldehydic products, such as 4-hydroxynonenal (HNE) that modify proteins and form adducts with DNA bases. To prevent damage by HNE, it is metabolized. The primary metabolic products are the glutathione conjugate (GSH-HNE), the corresponding 4-hydroxynonenoic acid (HNA), and the alcohol 1,4-dihydroxynonene (DHN). Since HNE metabolism can potentially change during in vitro aging, cell cultures of primary human dermal fibroblasts from several donors were cultured until senescence. After different time points up to 30 min of incubation with 5 \ub5M HNE, the extracellular medium was analyzed for metabolites via liquid chromatography coupled with electrospray ionization mass spectrometry (LC/ESI-MS). The metabolites appeared in the extracellular medium 5 min after incubation followed by a time-dependent increase. But, the formation of GSH-HNL and GSH-DHN decreased with increasing in vitro age. As a consequence, the HNE levels in the cells increase and there is more protein modification observed. Furthermore, after 3 h of incubation with 5 \ub5M HNE, younger cells showed less proliferative capacity, while in older cells slight increase in the mitotic index was noticed

Mixed RF-VLC Relaying Systems for Interference-Sensitive Mobile Applications

Due to their Radio-Frequency (RF) immunity, Visible Light Communications (VLC) pose as a promising technology for interference sensitive applications such as medical data networks. In this paper, we investigate mixed RF-VLC relaying systems especially suited for this type of applications that support mobility. In this system setup, the end-user, who is assumed to be on a vehicle that is in dynamic movement, is served by an indoor VLC system, while the outdoor data traffic is conveyed through multiple backhaul RF links. Furthermore, it is assumed that a single backhaul RF link is activated by the mobile relay and due to feedback delay, the RF link activation is based on outdated channel state information (CSI). The performance of this system is analyzed in terms of outage probability and bit error rate (BER), and novel closed form analytical expressions are provided. Furthermore, the analysis is extended for the case where the average SNR over the RF links and/or LED optical power is high, and approximate analytical expressions are derived which determine performance floors. Numerical results are provided which demonstrate that the utilization of multiple RF backhaul links can significantly improve overall RF-VLC system performance when outage/BER floors are avoided. This calls upon joint design of both subsystems. Additionally, the outdated CSI exploited for active RF selection can significantly degrade the quality of system performance.Comment: Published in IEEE Transactions on Vehicular Technolog

Reporting of social deprivation in musculoskeletal trials: an analysis of 402 randomised controlled trials

Background: Social deprivation is broadly defined as the restriction of access an individual has to social or cultural interactions due to poverty, discrimination or other disadvantages. While social deprivation is a widely acknowledged determinant of outcome in musculoskeletal conditions, it remains unclear how this is considered in the conduct and interpretation of musculoskeletal trials.  Aim: To determine the frequently to which measures of social deprivation are reported in trials recruiting people with musculoskeletal diseases.  Materials and Methods: We conducted a Pubmed search of randomised controlled trials published between 01 January 2019 and 01 June 2020. We included full-text papers of trials recruiting people with musculoskeletal diseases, irrespective of intervention type or origin. We extracted data relating to trial characteristics, setting, trial design, funding source and musculoskeletal disease. We extracted data on any reported social deprivation index or measure of social deprivation based on internationally adopted indicators. We analysed data descriptively to summarise the reporting of each social deprivation index and measure of social deprivation within trials.  Results: From 2133 potentially eligible citations, 402 were eligible. Mean age of participants was 51.7 years; 63% were female. Trials most frequently recruited people with spinal pain (24.6%) or osteoarthritis (10.0%). Two trials (0.5%) reported social deprivation indices/scores. When assessed by discrete measures of social deprivation, 164 trials (40.8%) reported one or more social deprivation measures. The most commonly reported measures were morbidity (20.2%), employment status (17.7%) and educational attainment (15.5%). Race (6.7%), ethnicity (6.2%) and annual salary (1.3%) were infrequently reported. One trial (0.3%) presented subgroup results by social deprivation measures.  Discussion and Conclusion: Social deprivation is inconsistently reported in musculoskeletal trials. Trialists should report baseline measures of social deprivation in trial reports and aid generalisability to target population, and to examine whether social deprivation might modify treatment effects of interventions for musculoskeletal conditions

Within study comparisons and risk of bias in international development: Systematic review and critical appraisal

Background Many systematic reviews incorporate nonrandomised studies of effects, sometimes called quasi‐experiments or natural experiments. However, the extent to which nonrandomised studies produce unbiased effect estimates is unclear in expectation or in practice. The usual way that systematic reviews quantify bias is through “risk of bias assessment” and indirect comparison of findings across studies using meta‐analysis. A more direct, practical way to quantify the bias in nonrandomised studies is through “internal replication research”, which compares the findings from nonrandomised studies with estimates from a benchmark randomised controlled trial conducted in the same population. Despite the existence of many risks of bias tools, none are conceptualised to assess comprehensively nonrandomised approaches with selection on unobservables, such as regression discontinuity designs (RDDs). The few that are conceptualised with these studies in mind do not draw on the extensive literature on internal replications (within‐study comparisons) of randomised trials. Objectives Our research objectives were as follows: Objective 1: to undertake a systematic review of nonrandomised internal study replications of international development interventions. Objective 2: to develop a risk of bias tool for RDDs, an increasingly common method used in social and economic programme evaluation. Methods We used the following methods to achieve our objectives. Objective 1: we searched systematically for nonrandomised internal study replications of benchmark randomised experiments of social and economic interventions in low‐ and middle‐income countries (L&MICs). We assessed the risk of bias in benchmark randomised experiments and synthesised evidence on the relative bias effect sizes produced by benchmark and nonrandomised comparison arms. Objective 2: We used document review and expert consultation to develop further a risk of bias tool for quasi‐experimental studies of interventions (ROBINS‐I) for RDDs. Results Objective 1: we located 10 nonrandomised internal study replications of randomised trials in L&MICs, six of which are of RDDs and the remaining use a combination of statistical matching and regression techniques. We found that benchmark experiments used in internal replications in international development are in the main well‐conducted but have “some concerns” about threats to validity, usually arising due to the methods of outcomes data collection. Most internal replication studies report on a range of different specifications for both the benchmark estimate and the nonrandomised replication estimate. We extracted and standardised 604 bias coefficient effect sizes from these studies, and present average results narratively. Objective 2: RDDs are characterised by prospective assignment of participants based on a threshold variable. Our review of the literature indicated there are two main types of RDD. The most common type of RDD is designed retrospectively in which the researcher identifies post‐hoc the relationship between outcomes and a threshold variable which determines assignment to intervention at pretest. These designs usually draw on routine data collection such as administrative records or household surveys. The other, less common, type is a prospective design where the researcher is also involved in allocating participants to treatment groups from the outset. We developed a risk of bias tool for RDDs. Conclusions Internal study replications provide the grounds on which bias assessment tools can be evidenced. We conclude that existing risk of bias tools needs to be further developed for use by Campbell collaboration authors, and there is a wide range of risk of bias tools and internal study replications to draw on in better designing these tools. We have suggested the development of a promising approach for RDD. Further work is needed on common methodologies in programme evaluation, for example on statistical matching approaches. We also highlight that broader efforts to identify all existing internal replication studies should consider more specialised systematic search strategies within particular literatures; so as to overcome a lack of systematic indexing of this evidence