Sairauspoissaolotarpeen määrittäminen : Kyselytutkimus lääkäreille

Kelan tutkimusosasto ja Suomen Lääkäriliitto toteuttivat vuonna 2014 lääkäreille kohdistetun kyselyn, jonka tarkoituksena on kartoittaa lääkäreiden näkemyksiä ja kokemuksia sairauspoissaoloihin liittyvistä käytännöistä ja kehittämistarpeista. Kysely perustuu vuonna 2012 Ruotsissa tehtyyn kyselyyn. Vastaava kysely toteutettiin myös Norjassa. Kysymykset on muokattu kunkin maan järjestelmään sopiviksi. Kyselylomake lähetettiin 8 867 lääkärille loppuvuodesta 2014, ja siihen saattoi vastata joko paperisella tai sähköisellä lomakkeella. Vastausprosentti oli 34,8. Rakenteeltaan aineisto edusti perusjoukkoa, joskin työterveyshuolto oli hieman yliedustettuna. Lääkärit pitivät julkisen sektorin palvelujen saatavuutta keskeisenä syynä sairauspoissaolojen pitkittymiseen. Myös vajaakuntoisten työntekijöiden työssä jaksamista tukevien toimenpiteiden saatavuus vaikutti sairauspoissaolojen kirjoittamiseen. Kelalta toivottiin enemmän palautetta lääkärien omasta toiminnasta. Lääkärien osaamisen kehittämistarpeet korostuivat erityisesti terveyskeskuksissa, mutta koulutusta tarvitsevien osuus on varsin suuri muillakin toimintasektoreilla. Lääkärit toivoivat laajasti, erikoistumisalasta tai toimipaikasta riippumatta, vähintäänkin joitakin sairauksia koskevia kansallisia suosituksia sairauspoissaolojen kestosta. Nykyisiä käytettävissä olevia ohjeita ja suosituksia monet lääkärit pitivät tärkeinä. Työterveyslääkärit erottuivat monissa kohdin omaksi ryhmäkseen. He näyttävät hallitsevan työkyvyn ja sairauspoissaolon tarpeen arviointiin liittyvät tehtävät parhaiten. Suomalaiset lääkärit kokivat ruotsalaisia ja norjalaisia perusterveydenhuollon lääkäreitä vähemmän ongelmia sairauspoissaoloon liittyvissä asioissa. Tutkimuksen perusteella annetuissa suosituksissa esitetään puuttumista jatkohoidon ja kuntoutukseen pääsyn viiveisiin, työkyvyn arviointiin liittyvän koulutuksen lisäämistä, sairauspoissaolotarpeen siirtämistä enemmän työterveyshuollon vastuulle sekä sairauspoissaolojen kestoa koskevien suositusten laatimista ainakin joistakin sairauksista

Distribution Patterns of E-Cadherin, Type VII Collagen and Fibronectin in Denture-Related Stomatitis: A Preliminary Study

The distribution of epithelial E-cadherin, basement membrane type VII collagen, and underlying connective tissues fibronectin were investigated immunohistochemically and compared in normal palatal mucosa and in denture-related stomatitis (DRS) derivatives using monoclonal antibodies.Biopsies of palatal mucosa were obtained from twelve patients enrolled in this study, 8 with type II DRS and 4 with healthy mucosa

Effect of amine fluoride-stannous fluoride preparations on oral yeasts in the elderly: A randomised placebo-controlled trial

Objectives: Oral yeast infections are an emerging problem among medically compromised and frail elderly. Antifungal drug resistance is also increasing because of an increase in non-albicans Candida strains in these populations. We therefore set out to study, in the randomised-controlled trial setting if the use of a topical amine fluoride-stannous luoride combination (AmF-SnF 2) could control oral Candida growth in the elderly. The hypothesis was based on earlier findings showing that in vitro this combination had antifungal efficacy. Methods: A total of 194 nursing home residents were randomised to receive either the test mouth rinse and toothpaste or a placebo twice daily for 8 months. Of these, 136 completed the trial. Saliva samples were taken using the oral rinse method, cultivated and the strain level identified with routine microbial methods. Compliance and use of preparations was assessed by a nurse. Results: Significantly at the end of the trial, less mucosal lesions were observed in the test group in comparison to controls. Total bacterial count decreased in both the groups during the trial. Candida albicans was the most prevalent strain detected both at baseline and 8 months later. Only a few subjects carried non-albicans strains. The AmF-SnF2 did not significantly affect mean oral Candida counts, but median Candida counts were reduced in the AmF-SnF2 group while an increase was seen in the placebo group. However, the differences observed were not statistically significant. Compliance among the regular elderly users slightly increased during the trial for both the groups. Conclusion: The number of subjects with high Candida counts decreased in the AmF-SnF2 group. Hence, the fluoride combination might be useful as a support therapy for oral candidiasis. Prevalence of non-albicans Candida strains was low in this population. © 2009 The Gerodontology Society and John Wiley & Sons A/S.link_to_subscribed_fulltex

Effect of graphene oxide fibre surface modification on low-velocity impact and fatigue performance of flax fibre reinforced composites

Fatigue and impact resistance are essential performance indicators in structural biocomposites. Integrating multilayer and oxygen-rich graphene oxide (GO) crystals as a fibre surface modification or reinforcing agent in polymer matrix systems have been shown to enhance the interfacial strength and toughness of natural fibre composites. However, the state-of-the-art literature on the GO-modification of composites has focused mainly on their microscale and quasi-static mechanical performance. Here, the fatigue testing results showed that surface modification of flax fibres with GO reduces the slope of the S-N curve by 17% and promotes fibre pull-outs upon failure. Based on the in-situ impact damage analysis, the GO-modification delayed the impact damage initiation and prolonged the stable damage progression phase. The impact perforation energy was similar for modified and unmodified specimens. At kinetic energies below the perforation limit, the GO-modification suppressed the extent of fibre failure and endowed flax-epoxy specimens with better damping performance

Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence

Integrated antibiotic resistance (AR) surveillance is one of the objectives of the World Health Organization global action plan on antimicrobial resistance. Urban wastewater treatment plants (UWTPs) are among the most important receptors and sources of environmental AR. On the basis of the consistent observation of an increasing north-to-south clinical AR prevalence in Europe, this study compared the influent and final effluent of 12 UWTPs located in seven countries (Portugal, Spain, Ireland, Cyprus, Germany, Finland, and Norway). Using highly parallel quantitative polymerase chain reaction, we analyzed 229 resistance genes and 25 mobile genetic elements. This first trans-Europe surveillance showed that UWTP AR profiles mirror the AR gradient observed in clinics. Antibiotic use, environmental temperature, and UWTP size were important factors related with resistance persistence and spread in the environment. These results highlight the need to implement regular surveillance and control measures, which may need to be appropriate for the geographic regions.This work was financed by the Water JPI through the national funding agencies supporting the consortium WaterJPI/0001/2013 STARE—“Stopping Antibiotic Resistance Evolution” (Cyprus, RPF; Germany, BMBF; Spain, MINECO; Finland, AKA; Ireland, EPA; Norway, RCN; Portugal, FCT). I.V.-M. was supported by the FCT grant SFRH/BPD/87360/2012, C.N.-d.-R. by the FCT grant SFRH/BD/97131/2013, and I.H. by the FCT contract IF/00492/2013. Other funders: A grant from the Michigan State University Center for Health Impacts of Agriculture (CHIA) and the National Natural Science Foundation of China (21677149)