Centrioles: active players or passengers during mitosis?

Centrioles are cylinders made of nine microtubule (MT) triplets present in many eukaryotes. Early studies, where centrosomes were seen at the poles of the mitotic spindle led to their coining as “the organ for cell division”. However, a variety of subsequent observational and functional studies showed that centrosomes might not always be essential for mitosis. Here we review the arguments in this debate. We describe the centriole structure and its distribution in the eukaryotic tree of life and clarify its role in the organization of the centrosome and cilia, with an historical perspective. An important aspect of the debate addressed in this review is how centrioles are inherited and the role of the spindle in this process. In particular, germline inheritance of centrosomes, such as their de novo formation in parthenogenetic species, poses many interesting questions. We finish by discussing the most likely functions of centrioles and laying out new research avenues

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review addresses ferulic acid dietary sources, the pharmacokinetic profile, antioxidant action mechanisms and therapeutic effects in the treatment and prevention of various diseases, in order to provide a basis for understanding its mechanisms of action as well as its pharmaceutical potential

Sound Quality Evaluation and Optimization for Interior Noise of Rail Vehicle

A procedure for sound filed simulation, sound quality (SQ) evaluation, and optimization of interior noise of a rail vehicle is investigated in this paper. Firstly, some interior noises are measured on site when the subway is running in tunnel at a speed of 60 km/h. The sound pressure levels (SPLs), loudness, sharpness, and roughness of the measured noise are analyzed. A finite element model for acoustical simulation of the carriage is established by using the Actran software. The accuracy and feasibility of the finite model are verified by comparing the psychoacoustical parameters from the simulations and measurements. By using orthogonal experimental design, finally, the best optimization scheme is put forward, which obtained a sound quality improvement with a 4.81 dB decrease in SPL and a 1.07 sone reduction in loudness. The proposed optimization scheme may be extended to other vehicles for improving interior acoustic environment