The Resurgence of Forced Labor: How the Sixth Circuit\u27s Decision in United States v. Toviave Endorses the Exploitation of Children

Comment arguing that the Sixth Circuit decision in United States v. Toviave was erroneous because the court failed to determine that the alleged forced labor was used as a means to control the children in the case. The comment looks at the reasoning in Toviave and explores the Sixth Circuit\u27s reasoning in the case as well as the Federal Forced Labor Statute, the Federal Involuntary Servitude Statute and Michigan\u27s current child abuse laws

Disposable Bioprocessing Systems

Because of many misconceptions, the biological drug manufacturing industry does not fully utilize disposable components, despite their wide availability. These misconceptions include concerns for the quality of materials, running costs, scalability, the level of automation possible, and the training of staff needed to include these components in existing bioprocessing systems. Not fully realizing the long-term benefits, many manufacturers are unwilling to discard investments made in fixed equipment and traditional stainless steel systems. Regulatory and environmental concerns, however, will eventually compel manufacturers to adopt disposable systems. Making a strong case for disposables, Disposable Bioprocessing Systems demonstrates the true potential of these systems. Written by a researcher and professor with hands-on experience in designing, establishing, and validating biological manufacturing facilities worldwide, and creating model facilities using maximum disposable technology, this book is the first comprehensive introduction to understanding disposable systems. It gives an overview of the current state of the disposable bioprocessing industry, resolves all controversial issues, and guides readers in choosing disposable components that meet their needs. An important chapter on safety addresses facts and myths about the use of plastics and elastomers—including the issue of leaching—and how to ensure regulatory compliance. Helping readers understand their choices, the book describes the equipment and systems available to prepare the starting materials for the manufacturing of biological drugs—from disposable containers to filters. The author also discusses costs, regulations, and concerns about waste disposal, and shares his predictions for the future of the disposable bioprocessing industry. A practical manual for those interested in the transition to disposable systems, this book will also interest students of bioprocessing. It offers a timely view of disposable bioprocessing technology as a "game changer" that will facilitate developing new drugs and conducting research in the emerging field of stem cells and gene therapy

Towards A Novel Unified Framework for Developing Formal, Network and Validated Agent-Based Simulation Models of Complex Adaptive Systems

Literature on the modeling and simulation of complex adaptive systems (cas) has primarily advanced vertically in different scientific domains with scientists developing a variety of domain-specific approaches and applications. However, while cas researchers are inherently interested in an interdisciplinary comparison of models, to the best of our knowledge, there is currently no single unified framework for facilitating the development, comparison, communication and validation of models across different scientific domains. In this thesis, we propose first steps towards such a unified framework using a combination of agent-based and complex network-based modeling approaches and guidelines formulated in the form of a set of four levels of usage, which allow multidisciplinary researchers to adopt a suitable framework level on the basis of available data types, their research study objectives and expected outcomes, thus allowing them to better plan and conduct their respective research case studies. Firstly, the complex network modeling level of the proposed framework entails the development of appropriate complex network models for the case where interaction data of cas components is available, with the aim of detecting emergent patterns in the cas under study. The exploratory agent-based modeling level of the proposed framework allows for the development of proof-of-concept models for the cas system, primarily for purposes of exploring feasibility of further research. Descriptive agent-based modeling level of the proposed framework allows for the use of a formal step-by-step approach for developing agent-based models coupled with a quantitative complex network and pseudocode-based specification of the model, which will, in turn, facilitate interdisciplinary cas model comparison and knowledge transfer. Finally, the validated agent-based modeling level of the proposed framework is concerned with the building of in-simulation verification and validation of agent-based models using a proposed Virtual Overlay Multiagent System approach for use in a systematic team-oriented approach to developing models. The proposed framework is evaluated and validated using seven detailed case study examples selected from various scientific domains including ecology, social sciences and a range of complex adaptive communication networks. The successful case studies demonstrate the potential of the framework in appealing to multidisciplinary researchers as a methodological approach to the modeling and simulation of cas by facilitating effective communication and knowledge transfer across scientific disciplines without the requirement of extensive learning curves

Computer-Aided Drug Design and Drug Discovery: A Prospective Analysis

In the dynamic landscape of drug discovery, Computer-Aided Drug Design (CADD) emerges as a transformative force, bridging the realms of biology and technology. This paper overviews CADDs historical evolution, categorization into structure-based and ligand-based approaches, and its crucial role in rationalizing and expediting drug discovery. As CADD advances, incorporating diverse biological data and ensuring data privacy become paramount. Challenges persist, demanding the optimization of algorithms and robust ethical frameworks. Integrating Machine Learning and Artificial Intelligence amplifies CADDs predictive capabilities, yet ethical considerations and scalability challenges linger. Collaborative efforts and global initiatives, exemplified by platforms like Open-Source Malaria, underscore the democratization of drug discovery. The convergence of CADD with personalized medicine offers tailored therapeutic solutions, though ethical dilemmas and accessibility concerns must be navigated. Emerging technologies like quantum computing, immersive technologies, and green chemistry promise to redefine the future of CADD. The trajectory of CADD, marked by rapid advancements, anticipates challenges in ensuring accuracy, addressing biases in AI, and incorporating sustainability metrics. This paper concludes by highlighting the need for proactive measures in navigating the ethical, technological, and educational frontiers of CADD to shape a healthier, brighter future in drug discovery

Development of mouthparts in the tadpoles of Rana tigrina Daud

The morphology of the mouthparts of Rana tigrina tadpoles is studied. The development starts after hatching with distinct mouth opening and is followed by paired beaks and labial fringes. The horny teeth then start differentiating in both the labial fringes and by addition of successive rows of teeth the full complement of larval dentition is developed. The mouthparts persist upto stage 50 and by stage 51 both the beaks and teeth are shed and the labial fringes are considerably resorbed

Long range magnetic ordering in a spin-chain compound, Ca3_3CuMnO6_6, with multiple bond distances

The results of ac and dc magnetization and heat capacity measurements as a function of temperature (T = 1.8 to 300 K) are reported for a quasi-one-dimensional compound, Ca$_3$CuMnO$_6$, crystallizing in a triclinically distorted K$_4$CdCl$_6$-type structure. The results reveal that this compound undergoes antiferromagnetic ordering close to 5.5 K. In addition, there is another magnetic transition below 3.6 K. Existence of two long-range magnetic transitions is uncommon among quasi-one-dimensional systems. It is interesting to note that both the magnetic transitions are of long-range type, instead of spin-glass type, in spite of the fact that the Cu-O and Mn-O bond distances are multiplied due to this crystallographic distortion. In view of this, this compound could serve as a nice example for studying "order-in-disorder" phenomena.Comment: Physical Review (in press

Critical behavior at de-pinning of a driven disordered vortex matter in 2H-NbS2

We report unusual jamming in driven ordered vortex flow in 2H-NbS2. Reinitiating movement in these jammed vortices with a higher driving force, and halting it thereafter once again with a reduction in drive, unfolds a critical behavior centered around the de-pinning threshold via divergences in the lifetimes of transient states, validating the predictions of a recent simulation study, which also pointed out a correspondence between plastic de-pinning in vortex matter and the notion of random organization proposed in the context of sheared colloids undergoing diffusive motion.Comment: Phys. Rev. B (in press, 2012). The paper has 14 pages of Text+ Refs. with 4 figures. (Note as some of the figure files are large in size, to enable faster download, the file size has been kept small and the figure resolution are low. The online version of the paper to appear in PRB will contain the higher resolution figures

Magnetic frustration in a stoichiometric spin-chain compound, Ca3_3CoIrO6_6

The temperature dependent ac and dc magnetization and heat capacity data of Ca$_3$CoIrO$_6$, a spin-chain compound crystallizing in a K$_4$CdCl$_6$-derived rhombohedral structure, show the features due to magnetic ordering of a frustrated-type below about 30 K, however without exhibiting the signatures of the so-called "partially disordered antiferromagnetic structure" encountered in the isostructural compounds, Ca$_3$Co$_2$O$_6$ and Ca$_3$CoRhO$_6$. This class of compounds thus provides a variety for probing the consequences of magnetic frustration due to topological reasons in stoichiometric spin-chain materials, presumably arising from subtle differences in the interchain and intrachain magnetic coupling strengths. This compound presents additional interesting situations in the sense that, ac susceptibility exhibits a large frequency dependence in the vicinity of 30 K uncharacteristic of conventional spin-glasses, with this frustrated magnetic state being robust to the application of external magnetic fields.Comment: Physical Review (Rapid Communications), in pres

Non-linear optimized spatial filter for single-trial identification of movement related cortical potential

To investigate the optimal filter settings for pre-processing of Movement Related Cortical Potentials (MRCP) for the detection through EEG in single trial, we have proposed a novel Non-Linear Optimized Spatial Filter (NL-SF) and compared it to the Optimized Spatial Filtering (OSF) used in literature. MRCPs from EEG recordings are emphasized, calculating the optimal non-linear combination of channels which isolates the signal of interest. The method is applied to EEG data recorded from 16 healthy patients either executing or imagining 50 self-paced upper limb movements (palmar grasp). MRCPs have been identified from the outputs of the two filters by matching with a template built by averaging responses to movement intentions in the training set. NL-SF had a median accuracy on the overall dataset of 84.6%, which is significantly better than that of OSF (i.e., 76.9%). Being a filter and feasible for self-paced applications, it could be of interest in online BCI system design