Bildung-gospels and adult education

The online pre-seminar ‘Bildung-gospel: a salvation to wicked problems?’ was organized on February 9th, 2022, as part of the Finnish adult education research conference in Tampere University. Due to the exploding fashionability of the word ‘Bildung’ in adult education practice and politics, the organizers asked in the pre-seminar questions on ‘What is the distinctive intellectual content and educational mission of (Nordic) Bildung and of the current initiatives of Bildung-gospel?’, ‘How does the current Bildung-gospel relate to intellectual and educational traditions of (Nordic) Bildung?’, ‘What might be reasons and drives behind the rise of the Bildung-gospel? With what kind of (educational) implications?’ Invited experts provided their responses on each question, followed by group and plenary discussions. The paper briefly describes key issues raised by the presenters and other participants, and authors’ interpretation on responses to the preliminary questions

Computed tomography-osteoabsorptiometry for assessing the density distribution of subchondral bone as a measure of long-term mechanical adaptation in individual joints

To estimate subchondral mineralisation patterns which represent the long-term loading history of individual joints, a method has been developed employing computed tomography (CT) which permits repeated examination of living joints. The method was tested on 5 knee, 3 sacroiliac, 3 ankle and 5 shoulder joints and then investigated with X-ray densitometry. A CT absorptiometric presentation and maps of the area distribution of the subchondral bone density areas were derived using an image analyser. Comparison of the results from both X-ray densitometry and CT-absorptiometry revealed almost identical pictures of distribution of the subchondral bone density. The method may be used to examine subchondral mineralisation as a measure of the mechanical adaptability of joints in the living subject

Identification of an Allosteric Small-Molecule Inhibitor Selective for the Inducible Form of Heat Shock Protein 70

Inducible Hsp70 (Hsp70i) is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis, poor outcomes, and resistance to chemotherapy in patients. Identification of small molecule inhibitors selective for Hsp70i could provide new therapeutic tools for cancer treatment. In this work, we used fluorescence-linked enzyme chemoproteomic strategy (FLECS) to identify HS-72, an allosteric inhibitor selective for Hsp70i. HS-72 displays the hallmarks of Hsp70 inhibition in cells, promoting substrate protein degradation and growth inhibition. Importantly, HS-72 is selective for Hsp70i over the closely related constitutively active Hsc70. Studies with purified protein show HS-72 acts as an allosteric inhibitor, reducing ATP affinity. In vivo HS-72 is well-tolerated, showing bioavailability and efficacy, inhibiting tumor growth and promoting survival in a HER2+ model of breast cancer. The HS-72 scaffold is amenable to resynthesis and iteration, suggesting an ideal starting point for a new generation of anticancer therapeutics targeting Hsp70i

Kompetenzentwicklung der Zukunft: Forschung - Praxis - Politik

In diesem abschließenden Beitrag, der von einem Autorenkollektiv der beiden Fokusgruppen verfasst wurde, werden aus den Verbundprojekten prospektive Überlegungen zu Arbeit, Kompetenzentwicklung und Innovation extrahiert. Den Projektarchitekturen entsprechend werden Desiderate von Beteiligten aus Wissenschaft und betrieblicher Praxis sowie von arbeitsmarkt-, sozial- und wirtschaftspolitischen Akteuren/-innen perspektivengeleitet zusammengestellt. Sie basieren auf den Erfahrungen und Erkenntnissen, die aus zwei- bis dreijährigen Erprobungslaufzeiten der jeweiligen Projekte gewonnen werden konnten