Transplantation of mesenchymal stem cells from young donors delays aging in mice

Increasing evidence suggests that the loss of functional stem cells may be important in the aging process. Our experiments were originally aimed at testing the idea that, in the specific case of age-related osteoporosis, declining function of osteogenic precursor cells might be at least partially responsible. To test this, aging female mice were transplanted with mesenchymal stem cells from aged or young male donors. We find that transplantation of young mesenchymal stem cells significantly slows the loss of bone density and, surprisingly, prolongs the life span of old mice. These observations lend further support to the idea that age-related diminution of stem cell number or function may play a critical role in age-related loss of bone density in aging animals and may be one determinant of overall longevity

Child language disability Volume 3; hearing impairment

Available from British Library Document Supply Centre- DSC:94/00383 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

Changing Men: Challenging Stereotypes. Reflections on Working with Men on Gender Issues in India

This article describes the journey and lessons of a 12?year?long and still ongoing experience of the two authors in working with men at the community level in different parts of India. Starting with addressing domestic violence, the work has proceeded to address issues of power, control and autonomy within the context of deep?seated cultural beliefs and practices, challenging and changing the roles of men both within homes and outside in different institutions. This work has been spread over a number of ‘projects’, most of which remain interconnected, and currently is spread across a number of states in India. In reviewing the lessons from their practice the authors propose a set of precepts or a ‘theory of change’ for working with men and boys to challenge gender discrimination within the South Asian context. To conclude the article, the authors discuss some of the challenges and predicaments in continuing this work within the current development paradigm

Hear and say Toys for children with hearing, speech and language difficulties

Previous edition revised in 1987 by; Susan Knowles and Helen DaweAvailable from British Library Document Supply Centre-DSC:f99/3546 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

First language maintenance and development by British-born Chinese children in Tyneside

Period of award 1 Oct 1995 - 30 Sep 1998Available from British Library Document Supply Centre-DSC:3739.0605(R000235869) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo