Miner K. Kellogg letter to Moses Dawson

Letter from Kellogg (Hermitage) to Dawson (Cincinnati, Ohio) regarding a portrait of Jackson soon to be finished and predicting its success. Letter also addresses Jackson\u27s health, character, and opinions; presidential campaign in Tennessee; and a projected portrait of Polk.https://www.exhibit.xavier.edu/dawson_correspondence/1093/thumbnail.jp

Orientation and temperature dependence of some mechanical properties of the single-crystal nickel-base superalloy Rene N4. 3: Tension-compression anisotropy

Single crystal superalloy specimens with various crystallographic directions along their axes were tested in compression at room temperature, 650, 760, 870, and 980 deg C. These results are compared with the tensile behavior studied previously. The alloy, Rene N4, was developed for gas turbine engine blades and has the nominal composition 3.7 Al, 4.2 Ti, 4 Ta, 0.5 Nb, 6 W, 1.5 Mo 9 Cr. 7.5 Co, balance Ni, in weight percent. Slip trace analysis showed that primary cube slip occurred even at room temperature for the 111 specimens. With increasing test temperature more orientations exhibited primary cube slip, until at 870 deg C only the 100 and 011 specimens exhibited normal octahedral slip. The yield strength for octahedral slip was numerically analysed using a model proposed by Lall, Chin, and Pope to explain deviations from Schmid's Law in the yielding behavior of a single phase Gamma prime alloy, Ni3(Al, Nb). The Schmid's Law deviations in Rene N4 were found to be largely due to a tension-compression anisotropy. A second effect, which increases trength for orientations away from 001, was found to be small in Rene N4. Analysis of recently published data on the single crystal superalloy PWA 1480 yielded the same result

Exploring the effect of language concordance between nurses and Limited English Proficient patients on their health outcomes.

Communication is essential to the medical field. Approximately 350 different languages are spoken in the USA. The commonality of language discordance between patients and health care providers causes poor communication, limited understanding of their condition, and a decrease in the patient’s satisfaction with their care. This literature review explored the effect that a language concurrent healthcare provider has on the health outcomes of LEP patients. LEP is defined as limited English proficiency. METHODS: CINHAL and Pubmed were used. The key terms used were communication barriers, language barriers, nurse, nurses, nursing, and health outcomes. The search revealed 719 articles. Seven articles were included from this search. Two were included from the recommendation function of the literature software Mendeley. Nine articles were included in total. The following filters were used: written in English, research articles, published between 2010-2020, full text, and peer-reviewed and available pdf. Inclusion factors were health outcomes of LEP patients, Health outcomes for patients who used interpreters, language concordance, and patient satisfaction based on language concordance. Seven articles were included based on the inclusion and exclusion criteria. Articles were excluded due to improper patient population, exclusion of language concordance, improper picot question, lack of professional hospital interpretation, or topics not exploring health outcomes of LEP patients. Nine articles were included in the literature review. RESULTS: Three common themes were identified, decreased patient satisfaction, missed points in care, and declining health outcomes. LEP patients had higher chances of being transferred to the ICU, death, and to be misassigned to lower acuity. Absence of crucial discharge information and dis-satisfaction with care were more likely to occur without language concordant care. CONCLUSION: For patients who are LEP, communication is impaired resulting in declining health outcomes, missed points in care, and decreased patient satisfaction. There was some contradiction in health outcomes for patients. Limitations were that interpreter presence and training level were not always known. Research should focus on health outcomes for LEP patients

Voters prefer candidates who send their children to public over private school

From presidential races to local elections, decisions about where politicians send their children to school can attract public attention. But do these choices actually impact how voters cast their ballots? In new research, Leslie K. Finger, Thomas Gift, and Andrew Miner use an original survey experiment to examine how voters view politicians who send their children to public versus private school. They find that voters are more likely support candidates whose children attend public school — an outcome they trace to voters perceiving these candidates as warmer and more committed to public services

Innovation in conducting writing retreats for academic staff in higher education

How do researchers and administrators in higher education plan and carry out writing retreats for academic staff? This paper presents a distinctive approach to developing creative writing retreats for academic staff in higher education. We distill lessons from our June 2016 writing retreat, which drew participants from the University of Venda and the University of Limpopo. Responding to the South African Journal of Higher Education’s invitation to “re-imagine” writing retreats, we specify the shortcomings of linear writing retreats and discuss how to enhance collaboration, participation, and leadership capacity in planning and carrying out writing retreats. We also focus on an oft-neglected yet crucial feature of retreats, follow-up. As we show, our approach offers general insights for creative designing and implementing writing retreats.

Successful nesting by 2 endangered Hawaiian waterbird species in a restored Indigenous wetland agroecosystem

The Hawaiian Stilt (Himantopus mexicanus knudseni) and Hawaiian Gallinule (Gallinula galeata sandvicensis) are federally endangered waterbirds endemic to the Hawaiian Islands. Both species are conservation-reliant; their population persistence is dependent on invasive predator control and removal of invasive plants that degrade habitat. We present observations of successful nesting by one Hawaiian Stilt pair and one Hawaiian Gallinule pair at a site managed within an adaptive Indigenous agroecological framework on the island of O‘ahu, Hawai‘i. The Hawaiian Stilt nest, found in February 2019, contained 4 eggs and produced 3 hatchlings, 2 of which were banded and monitored after hatching. The Hawaiian Gallinule nest, found in February 2020, contained 6 eggs and produced 5 hatchlings. Although no individuals were banded from this nest, 2 adults and 2 hatchlings were continuously observed in the nesting area after the eggs hatched. Lo‘i kalo Hawaiian wetland agroecosystems centered around the cultivation of kalo (taro; Colocasia esculenta), have the potential to expand Hawaiian waterbird habitat beyond state and federal protected areas. We are aware of unpublished accounts of Hawaiian waterbirds nesting in commercially farmed lo‘i kalo, but until now, there have been no previously published accounts of native waterbirds breeding in lo‘i kalo managed as Indigenous agroecosystems

Lesinurad, a novel, oral compound for gout, acts to decrease serum uric acid through inhibition of urate transporters in the kidney.

BackgroundExcess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of serum uric acid (sUA) levels. The URAT1 inhibitors probenecid and benzbromarone are used as gout therapies; however, their use is limited by drug-drug interactions and off-target toxicity, respectively. Here, we define the mechanism of action of lesinurad (Zurampic®; RDEA594), a novel URAT1 inhibitor, recently approved in the USA and Europe for treatment of chronic gout.MethodssUA levels, fractional excretion of uric acid (FEUA), lesinurad plasma levels, and urinary excretion of lesinurad were measured in healthy volunteers treated with lesinurad. In addition, lesinurad, probenecid, and benzbromarone were compared in vitro for effects on urate transporters and the organic anion transporters (OAT)1 and OAT3, changes in mitochondrial membrane potential, and human peroxisome proliferator-activated receptor gamma (PPARγ) activity.ResultsAfter 6 hours, a single 200-mg dose of lesinurad elevated FEUA 3.6-fold (p < 0.001) and reduced sUA levels by 33 % (p < 0.001). At concentrations achieved in the clinic, lesinurad inhibited activity of URAT1 and OAT4 in vitro, did not inhibit GLUT9, and had no effect on ABCG2. Lesinurad also showed a low risk for mitochondrial toxicity and PPARγ induction compared to benzbromarone. Unlike probenecid, lesinurad did not inhibit OAT1 or OAT3 in the clinical setting.ConclusionThe pharmacodynamic effects and in vitro activity of lesinurad are consistent with inhibition of URAT1 and OAT4, major apical transporters for uric acid. Lesinurad also has a favorable selectivity and safety profile, consistent with an important role in sUA-lowering therapy for patients with gout

Barrier-to-autointegration factor 1 protects against a basal cGAS-STING response

Although the pathogen recognition receptor pathways that activate cell-intrinsic antiviral responses are well delineated, less is known about how the host regulates this response to prevent sustained signaling and possible immune-mediated damage. Using a genome-wide CRISPR-Cas9 screening approach to identify host factors that modulate interferon-stimulated gene (ISG) expression, we identified the DNA binding protein Barrier-to-autointegration factor 1 (Banf1), a previously described inhibitor of retrovirus integration, as a modulator of basal cell-intrinsic immunity. Ablation of Banf1 by gene editing resulted in chromatin activation near host defense genes with associated increased expression of ISGs, includin