A histological investigation of \u3ci\u3eArceuthobium pusillum\u3c/i\u3e infections in \u3ci\u3ePicea rubens\u3c/i\u3e and \u3ci\u3ePicea glauca\u3c/i\u3e

Arceuthobium pusillum is a hemiparasite that infects select Picea species. The hosts of A. pusillum do not experience the same symptoms of infection. A. pusillum infections are more fatal to P. marinara, and P. glauca. P. rubens, on the other hand, can survive longer with sustained infection. This presents itself as a contemporary issue because P. glauca, one of the parasite’s most vulnerable hosts, was untethered from ecological competition when old growth forests were subjected to large scale anthropogenic disturbances. These disturbances allowed P. glauca to proliferate, with A. pusillum following. A deeper understanding of the host-species specific responses to A. pusillum infection can broaden general knowledge of parasitic growth and development while also potentially inspiring conservation techniques. This study took advantage of the intrinsic differences between host and parasite to visualize infections in P. rubens and P. glauca, highlighting differences in infection outcome. By illuminating lignin and callose within cross sections of infected P. rubens and P. glauca branches, it was revealed that P. rubens forms dense bands of cells around the cortical strands of infection. These bands form more frequently in P. rubens than in P. glauca and are of a significantly larger area in P. rubens than in P. glauca (t(8), p=0.003, p=0.005). The discovery of the exterior bands is novel and exciting, as the bands are possibly made of callose and potentially facilitate P. rubens survival against A. pusillum infection. The foundational discoveries and results of this study should inspire, and warrant, further analysis

Design and Implementation of a Measurement-Based Policy-Driven Resource Management Framework For Converged Networks

This paper presents the design and implementation of a measurement-based QoS and resource management framework, CNQF (Converged Networks QoS Management Framework). CNQF is designed to provide unified, scalable QoS control and resource management through the use of a policy-based network management paradigm. It achieves this via distributed functional entities that are deployed to co-ordinate the resources of the transport network through centralized policy-driven decisions supported by measurement-based control architecture. We present the CNQF architecture, implementation of the prototype and validation of various inbuilt QoS control mechanisms using real traffic flows on a Linux-based experimental test bed.Comment: in Ictact Journal On Communication Technology: Special Issue On Next Generation Wireless Networks And Applications, June 2011, Volume 2, Issue 2, Issn: 2229-6948(Online

The effect of farming system on dairy cow cleanliness in the UK and implications to udder health

The cleanliness of dairy cows was assessed using a 20 point hygiene score system at different times in the year on 14 organic and 14 conventional farms in the UK. Overall, cows were dirtier during winter housing compared to summer grazing. Farming system had no effect on cow cleanliness when cows were at grass, but when housed in the winter, organic cows were more likely to be cleaner. There was a link between cow hygiene scores and milk hygiene, with herds having lower bulk tank somatic cell counts (BTSCC) tending to have cleaner cows. This relationship was strongest for the organic herds. There was no significant link between hygiene score and Bactoscan (BS) count or mastitis incidence

Lagoon livelihoods: gender and shell money in Langalanga, Solomon Islands

© 2018, The Author(s). Gender shapes livelihoods through access to resources and the distribution of benefits from economic activities. To work effectively with local people, resource management and community development initiatives should therefore be sensitive to the influence of gender on livelihoods. This paper considers gender in the context of broader social trends around livelihoods and focuses on a case study of shell money production and trade in the Langalanga Lagoon in Malaita Province, Solomon Islands. We pool data from several recent research projects with historical material from secondary sources. We find that the gender division of labour in the shell money value chain has changed somewhat over time, particularly in that women are now actively involved in trading. However, this shift has created friction due to norms about what kinds of activities are suitable for women, and who should control cash incomes. Whilst shell money remains one of the most important livelihoods in Langalanga lagoon, our findings also illustrate that the shell money value chain and the income earned varies considerably from family to family, with some making a better living than others. We argue that interventions seeking to improve livelihoods in coastal communities should thus be based on an understanding of differentiation within communities, and practitioners should consider whether interventions will result in community development, or may have the impact of increasing inequality between families

Pattern of hiv-infection in Hurungwe District, Mashonaland West, Zimbabwe

A journal article on the pattern of HIV infection in a rural Zimbabwe district.After the first case of HIV-infection had been diagnosed in 1986 in a Northern district of Zimbabwe, a local hospital based surveillance system, was introduced. In order to monitor the spread of the epidemic in the district, residence, age, sex and clinical presentation of all newly diagnosed HIV-paticnts were recorded. After three years, the data were compiled and analysed with the following results. Altogether 887 symptomatic HIV-patients (0,5 pc of the district population) were diagnosed. The most common HIV-associated signs and symptoms were PGL (47 pc), chest infection (29 pc), herpes zoster (24 pc) and chronic STDs (15 pc). The fcmalc-to-malc ratio in adults was 1,4. The average age on diagnosis in women was 26,0±6,7 years and in men 30,7±8,6 years. The three years’ cumulative incidence of HIV-cases was 27,2/1 000 in the urban area and 3/1 000 in the rural areas of the district

Role of liraglutide in Alzheimer's disease pathology

Background The described relationship between Alzheimer's disease (AD) and type 2 diabetes (T2D) and the fact that AD has no succesful treatment has led to the study of antidiabetic drugs that may limit or slow down AD pathology. Main body Although T2D treatment has evident limitations, options are increasing including glucagon-like peptide 1 analogs. Among these, liraglutide (LRGT) is commonly used by T2D patients to improve beta cell function and suppress glucagon to restore normoglycaemia. Interestingly, LRGT also counterbalances altered brain metabolism and has anti-inflammatory properties. Previous studies have reported its capacity to reduce AD pathology, including amyloid production and deposition, tau hyperphosphorylation, or neuronal and synaptic loss in animal models of AD, accompanied by cognitive improvement. Given the beneficial effects of LRGT at central level, studies in patients have been carried out, showing modest beneficial effects. At present, the ELAD trial (Evaluating Liraglutide in Alzheimer's Disease NCT01843075) is an ongoing phase IIb study in patients with mild AD. In this minireview, we resume the outcomes of LRGT treatment in preclinical models of AD as well as the available results in patients up to date. Conclusion The effects of LRGT on animal models show significant benefits in AD pathology and cognitive impairment. While studies in patients are limited, ongoing clinical trials will probably provide more definitive conclusions on the role of LRGT in AD patients

An Unrecognized Source of PCB Contamination in Schools and Other Buildings

An investigation of 24 buildings in the Greater Boston Area revealed that one-third (8 of 24) contained caulking materials with polychlorinated biphenyl (PCB) content exceeding 50 ppm by weight, which is the U.S. Environmental Protection Agency (U.S. EPA) specified limit above which this material is considered to be PCB bulk product waste. These buildings included schools and other public buildings. In a university building where similar levels of PCB were found in caulking material, PCB levels in indoor air ranged from 111 to 393 ng/m(3); and in dust taken from the building ventilation system, < 1 ppm to 81 ppm. In this building, the U.S. EPA mandated requirements for the removal and disposal of the PCB bulk product waste as well as for confirmatory sampling to ensure that the interior and exterior of the building were decontaminated. Although U.S. EPA regulations under the Toxic Substances Control Act stipulate procedures by which PCB-contaminated materials must be handled and disposed, the regulations apparently do not require that materials such as caulking be tested to determine its PCB content. This limited investigation strongly suggests that were this testing done, many buildings would be found to contain high levels of PCBs in the building materials and potentially in the building environment. The presence of PCBs in schools is of particular concern given evidence suggesting that PCBs are developmental toxins