307 research outputs found
Population dynamics and life history of the rare arctic- alpine plant Sagina nivalis (Caryophyllaceae) on the Ben Lawers range, Scotland, UK
The flora of Scotland's mountains is of international significance as it contains arctic-alpine species at the edge of their global range. Such rear edge populations deserve high priority investigation due to their unique local adaptations, important conservation value and because montane plants may be particularly sensitive to environmental change. Sagina nivalis is one of the rarest and least known arctic-alpines in Britain and the vast majority of plants occur within the Ben Lawers SSSI. Ten permanent plots were surveyed here from 1982-1994 by counting the number of plants and tagging and measuring individuals throughout the duration of their lives. The total number of plants present at each colony across the whole site was also recorded in 1996 and 2014. Extreme fluctuations in numbers occurred within periods of very few years and were associated with the fragile and dynamic nature of the montane habitat. Seedling mortality was very high, but age had no effect on survival rates once plants were one year old. Most were small, only lived two years and produced none or few flowers, although those that survived long enough generally reached their maximum size and flowering potential when they were five years old. The number of plants present across the whole of Ben Lawers halved between 1996 and 2014, with half of all colonies extinct and a further third in significant decline. The greatest threats to S. nivalis in Scotland were identified as habitat damage due to natural processes, sheep activity and climate change. A reduction in snow cover may cause an interaction between these factors and compromise the long-term survival of rear edge populations of this species, other rare arctic-alpines in Scotland and their associated contribution to biodiversity
The efficacy of self-management strategies for females with endometriosis : a systematic review
Self-management is critical for the care of endometriosis. Females with endometriosis frequently use self-management strategies to manage associated symptoms; however, the efficacy of such strategies is unknown. The aim of this review was to systematically appraise the evidence concerning efficacy of self-management strategies for endometriosis symptoms. Electronic databases, including Medline, Embase, Emcare, Web of Science Core Collection, Scopus, and the Cochrane Central Register of Controlled Trials, were searched from inception to March 2021. We included peer-reviewed experimental studies published in English evaluating the efficacy of self-management strategies in human females laparoscopically diagnosed with endometriosis. Studies underwent screening, data extraction, and risk of bias appraisal (randomised studies: Risk of Bias 2 tool; non-randomised studies: Risk Of Bias In Non-randomized Studies – of Interventions tool). Of the fifteen studies included, 10 evaluated dietary supplements, three evaluated dietary modifications, one evaluated over-the-counter medication, and one evaluated exercise. Most studies had a high-critical risk of bias. Many self-management strategies were not more effective at reducing endometriosis symptoms compared to placebo or hormonal therapies. Where studies suggest efficacy for self-management strategies, no recommendations can be made due to the poor quality and heterogeneity of evidence. High-quality empirical evidence is required to investigate the efficacy of self-management strategies for females with endometriosis
A Definitive Signal of Multiple Supersymmetry Breaking
If the lightest observable-sector supersymmetric particle (LOSP) is charged
and long-lived, then it may be possible to indirectly measure the Planck mass
at the LHC and provide a spectacular confirmation of supergravity as a symmetry
of nature. Unfortunately, this proposal is only feasible if the gravitino is
heavy enough to be measured at colliders, and this condition is in direct
conflict with constraints from big bang nucleosynthesis (BBN). In this work, we
show that the BBN bound can be naturally evaded in the presence of multiple
sectors which independently break supersymmetry, since there is a new decay
channel of the LOSP to a goldstino. Certain regions of parameter space allow
for a direct measurement of LOSP decays into both the goldstino and the
gravitino at the LHC. If the goldstino/gravitino mass ratio is measured to be
2, as suggested by theory, then this would provide dramatic verification of the
existence of multiple supersymmetry breaking and sequestering. A variety of
consistent cosmological scenarios are obtained within this framework. In
particular, if an R symmetry is imposed, then the gauge-gaugino-goldstino
interaction vertices can be forbidden. In this case, there is no bound on the
reheating temperature from goldstino overproduction, and thermal leptogenesis
can be accommodated consistently with gravitino dark matter.Comment: 10 pages, 5 figures, title changed to match the version published in
JHE
A Brief Review on Dark Matter Annihilation Explanation for Excesses in Cosmic Ray
Recently data from PAMELA, ATIC, FERMI-LAT and HESS show that there are
excesses in the cosmic ray energy spectrum. PAMELA observed excesses
only in , but not in anti-proton spectrum. ATIC, FERMI-LAT and HESS
observed excesses in spectrum, but the detailed shapes are different
which requires future experimental observations to pin down the correct data
set. Nevertheless a lot of efforts have been made to explain the observed
excesses, and also why PAMELA only observed excesses in but not
in anti-proton. In this brief review we discuss one of the most popular
mechanisms to explain the data, the dark matter annihilation. It has long been
known that about 23% of our universe is made of relic dark matter. If the relic
dark matter was thermally produced, the annihilation rate is constrained
resulting in the need of a large boost factor to explain the data. We will
discuss in detail how a large boost factor can be obtained by the Sommerfeld
and Briet-Wigner enhancement mechanisms. Some implications for particle physics
model buildings will also be discussed.Comment: 22 pages, 6 figures. Several typoes corrected and some references
added. Published in Mod. Phys. Lett. A, Vol. 24, No. 27 (2009) pp. 2139-216
Neutralino Dark Matter in BMSSM Effective Theory
We study thermal neutralino dark matter in an effective field theory
extension of the MSSM, called "Beyond the MSSM" (BMSSM) in Dine, Seiberg and
Thomas (2007). In this class of effective field theories, the field content of
the MSSM is unchanged, but the little hierarchy problem is alleviated by
allowing small corrections to the Higgs/higgsino part of the Lagrangian. We
perform parameter scans and compute the dark matter relic density. The light
Higgsino LSP scenario is modified the most; we find new regions of parameter
space compared to the standard MSSM. This involves interesting interplay
between the WMAP dark matter bounds and the LEP chargino bound. We also find
some changes for gaugino LSPs, partly due to annihilation through a Higgs
resonance, and partly due to coannihilation with light stops in models that are
ruled in by the new effective terms.Comment: 37 pages + appendi
Parenting interventions for male young offenders: a review of the evidence on what works
Approximately one in four incarcerated male young offenders in the UK is an actual or expectant father. This paper reviews evidence on the effectiveness of parenting interventions for male young offenders. We conducted systematic searches across 20 databases and consulted experts. Twelve relevant evaluations were identified: 10 from the UK, of programmes for incarcerated young offenders, and two from the US, of programmes for young parolees. None used experimental methods or included a comparison group. They suggest that participants like the courses, find them useful, and the interventions may improve knowledge about, and attitudes to, parenting. Future interventions should incorporate elements of promising parenting interventions with young fathers in the community, for example, and/or with older incarcerated parents. Young offender fathers have specific developmental, rehabilitative, and contextual needs. Future evaluations should collect longer-term behavioural parent and child outcome data and should use comparison groups and, ideally, randomization
Decaying Hidden Dark Matter in Warped Compactification
The recent PAMELA and ATIC/Fermi/HESS experiments have observed an excess of
electrons and positrons, but not anti-protons, in the high energy cosmic rays.
To explain this result, we construct a decaying hidden dark matter model in
string theory compactification that incorporates the following two ingredients,
the hidden dark matter scenario in warped compactification and the
phenomenological proposal of hidden light particles that decay to the Standard
Model. In this model, on higher dimensional warped branes, various warped
Kaluza-Klein particles and the zero-mode of gauge field play roles of the
hidden dark matter or mediators to the Standard Model.Comment: 15 pages; v4, several clarifications added, update on Fermi/HESS
result
Decaying into the Hidden Sector
The existence of light hidden sectors is an exciting possibility that may be
tested in the near future. If DM is allowed to decay into such a hidden sector
through GUT suppressed operators, it can accommodate the recent cosmic ray
observations without over-producing antiprotons or interfering with the
attractive features of the thermal WIMP. Models of this kind are simple to
construct, generic and evade all astrophysical bounds. We provide tools for
constructing such models and present several distinct examples. The light
hidden spectrum and DM couplings can be probed in the near future, by measuring
astrophysical photon and neutrino fluxes. These indirect signatures are
complimentary to the direct production signals, such as lepton jets, predicted
by these models.Comment: 40 pages, 5 figure
Two component dark matter
We explain the PAMELA positron excess and the PPB-BETS/ATIC e+ + e- data
using a simple two component dark matter model (2DM). The two particle species
in the dark matter sector are assumed to be in thermal equilibrium in the early
universe. While one particle is stable and is the present day dark matter, the
second one is metastable and decays after the universe is 10^-8 s old. In this
model it is simple to accommodate the large boost factors required to explain
the PAMELA positron excess without the need for large spikes in the local dark
matter density. We provide the constraints on the parameters of the model and
comment on possible signals at future colliders.Comment: 6 pages, 2 figures, discussion clarified and extende
EphA2 as a Diagnostic Imaging Target in Glioblastoma: A Positron Emission Tomography/Magnetic Resonance Imaging Study
Noninvasive imaging is a critical technology for diagnosis, classification, and subsequent treatment planning for patients with glioblastoma. It has been shown that the EphA2 receptor tyrosine kinase (RTK) is overexpressed in a number of tumors, including glioblastoma. Expression levels of Eph RTKs have been linked to tumor progression, metastatic spread, and poor patient prognosis. As EphA2 is expressed at low levels in normal neural tissues, this protein represents an attractive imaging target for delineation of tumor infiltration, providing an improved platform for image-guided therapy. In this study, EphA2-4B3, a monoclonal antibody specific to human EphA2, was labeled with Cu-64 through conjugation to the chelator 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA). The resulting complex was used as a positron emission tomography (PET) tracer for the acquisition of high-resolution longitudinal PET/magnetic resonance images. EphA2-4B3-NOTA-Cu-64 images were qualitatively and quantitatively compared to the current clinical standards of [F-18] FDOPA and gadolinium (Gd) contrast-enhanced MRI. We show that EphA2-4B3-NOTA-Cu-64 effectively delineates tumor boundaries in three different mouse models of glioblastoma. Tumor to brain contrast is significantly higher in EphA2-4B3-NOTA-Cu-64 images than in [F-18] FDOPA images and Gd contrast-enhanced MRI. Furthermore, we show that nonspecific uptake in the liver and spleen can be effectively blocked by a dose of nonspecific (isotype control) IgG
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