Synovial cavernous hemangioma with juxta-articular hemangioma in a 29-year old woman: A case report

Introduction: Synovial hemangiomas are a rare benign vascular malformation that most commonly affects the knee joint, usually involving the anterior compartment. Histopathology examination is considered the gold standard for the diagnosis of synovial hemangioma. Surgical excision, either done per arthroscopy or per arthrotomy, is the treatment of choice. Presentation of case: This study presents a 29-year-old female admitted to our hospital in March 2020 who complained of continuous pain, swelling, and recurrent haemarthroses without a history of trauma for six months. The anteroposterior and lateral plain radiographs of the left knee showed no abnormality. An ultrasound of the left knee showed lobulated hypoechoic lesions in intra-articular and infra-suprapatellar pouches. Multiple vessels within the lesion with the low-velocity venous flow have appeared in color-Doppler imaging. Magnetic resonance imaging (MRI) of the left knee showed an irregular soft tissue mass in intra-articular fossa that infiltrating infra-suprapatellar pouches along to vastus medialis muscle (juxta-articular areas) measuring about 87 � 72 � 75 mm. Synovial effusion and bone erosions were notable. Fine-needle aspiration cytology (FNAC) offered hemarthrosis. The excisional biopsy obtained from the lesion and imprint cytology performed immediately after tissue removal. The cytologic diagnosis was compatible with a benign vascular neoplasm. The histologic exam confirmed synovial hemangioma. Discussion: Synovial hemangioma is a rare benign tumor of vascular origin arising from synovium-lined tissues, and often affects adolescents and young adults. Synovial hemangioma is often associated with an adjacent cutaneous or deep soft tissue hemangioma. It is a vascular malformation that contains variable amounts of adipose, fibrous, and muscle tissue, as well as thrombi in the vessels. At present, MRI has become the modality of choice for the evaluation of hemangiomas. The final diagnosis established with the histologic examination. The choice treatment is surgical excision. Conclusion: Although synovial hemangioma is a rare condition, be considered for non-specific clinical symptoms. However, an early diagnosis of synovial hemangioma is fundamental for adequate treatment. © 2020 The Author

Precision measurement of vector and tensor analyzing powers in elastic deuteron-proton scattering

High precision vector and tensor analyzing powers of elastic deuteron-proton d+p scattering have been measured at intermediate energies to investigate effects of three-nucleon forces (3NF). Angular distribution in the range of 70-120 degree in the center-of mass frame for incident-deuteron energies of 130 and 180 MeV were obtained using the RIKEN facility. The beam polarization was unambiguously determined by measuring the 12C(d,alpha)10B(2+) reaction at 0 degree. Results of the measurements are compared with state-of-the-art three-nucleon calculations. The present modeling of nucleon-nucleon forces and its extension to the three-nucleon system is not sufficient to describe the high precision data consistently and requires, therefore, further investigation

Optimizing the design of invasive placebo interventions in randomized controlled trials

The authors thank A. Skilton for preparing Fig. 1. This study was supported by the NIHR Biomedical Research Centre at University Hospitals Bristol National Health Service (NHS) Foundation Trust and the University of Bristol, MRC ConDuCT‐II (Collaboration and innovation for Difficult and Complex randomised controlled Trials In Invasive procedures) Hub for Trials Methodology Research (MR/K025643/1) (http://www.bristol.ac.uk/population‐health‐sciences/centres/conduct2), a NIHR senior investigator award (NF‐SI‐0514‐10114) and the Bristol Royal College of Surgeons Trials Centre. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The funders played no role in any aspect of the study design, analysis or publication decisions.Peer reviewedPublisher PD

Proton-deuteron radiative capture cross sections at intermediate energies

Differential cross sections of the reaction $p(d,^3{\rm He})\gamma$ have been measured at deuteron laboratory energies of 110, 133 and 180 MeV. The data were obtained with a coincidence setup measuring both the outgoing $^3$He and the photon. The data are compared with modern calculations including all possible meson-exchange currents and two- and three- nucleon forces in the potential. The data clearly show a preference for one of the models, although the shape of the angular distribution cannot be reproduced by any of the presented models.Comment: 6 pages, 6 figures, accepted for publication in EPJ

Measurement of the vector and tensor analyzing powers for dp- elastic scattering at 880 MeV

The vector Ay and tensor analyzing powers Ayy and Axx for dp- elastic scattering were measured at Td = 880 MeV over the c.m. angular range from 60 to 140 degrees at the JINR Nuclotron. The data are compared with predictions of different theoretical models based on the use of nucleon-nucleon forces only. The observed discrepancies of the measured analyzing powers from the calculations require the consideration of additional mechanisms.Comment: 5 pages,3 figure

Signatures of three-nucleon interactions in few-nucleon systems

Recent experimental results in three-body systems have unambiguously shown that calculations based only on nucleon-nucleon forces fail to accurately describe many experimental observables and one needs to include effects which are beyond the realm of the two-body potentials. This conclusion owes its significance to the fact that experiments and calculations can both be performed with a high accuracy. In this review, both theoretical and experimental achievements of the past decade will be underlined. Selected results will be presented. The discussion on the effects of the three-nucleon forces is, however, limited to the hadronic sector. It will be shown that despite the major successes in describing these seemingly simple systems, there are still clear discrepancies between data and the state-of-the-art calculations.Comment: accepted for publication in Rep. Prog. Phy

Measurement of differential cross sections for deuteron-proton breakup reaction at 160 MeV

Differential cross sections for deuteron breakup $^{1}H(d, pp)n$ reaction were measured for a large set of 243 geometrical configurations at the beam energy of 80 MeV/nucleon. The cross section data are normalized by the luminosity factor obtained on the basis of simultaneous measurement of elastic scattering channel and the existing cross section data for this process. The results are compared to the theoretical calculations modeling nuclear interaction with and without taking into account the three-nucleon force (3NF) and Coulomb interaction. In the validated region of the phase space both the Coulomb force and 3NF play an important role in a good description of the data. There are also regions, where the improvements of description due to including 3NF are not sufficient

Spin-isospin selectivity in three-nucleon forces

Precision data are presented for the break-up reaction, (2)H((p) over right arrow, pp)n, within the framework of nuclear-force studies. The experiment was carried out at KVI using a polarized-proton beam of 190 MeV impinging on a liquid-deuterium target and by exploiting the detector, BINA. Some of the vector-analyzing powers are presented and compared with state-of-the-art Faddeev calculations including three-nucleon forces effect. Significant discrepancies between the data and theoretical predictions were observed for kinematical configurations which correspond to the (2)H((p) over right arrow,(2)He)n channel. These results are compared to the (2)H((p) over right arrow, d)p reaction to test the isospin sensitivity of the present three-nucleon force models. The current modeling of two and three-nucleon forces is not sufficient to describe consistently polarization data for both isospin states. (C) 2010 Elsevier B.V. All rights reserved

Effects of histocompatibility and host immune responses on the tumorigenicity of pluripotent stem cells

Pluripotent stem cells hold great promises for regenerative medicine. They might become useful as a universal source for a battery of new cell replacement therapies. Among the major concerns for the clinical application of stem cell-derived grafts are the risks of immune rejection and tumor formation. Pluripotency and tumorigenicity are closely linked features of pluripotent stem cells. However, the capacity to form teratomas or other tumors is not sufficiently described by inherited features of a stem cell line or a stem cell-derived graft. The tumorigenicity always depends on the inability of the recipient to reject the tumorigenic cells. This review summarizes recent data on the tumorigenicity of pluripotent stem cells in immunodeficient, syngeneic, allogeneic, and xenogeneic hosts. The effects of immunosuppressive treatment and cell differentiation are discussed. Different immune effector mechanisms appear to be involved in the rejection of undifferentiated and differentiated cell populations. Elements of the innate immune system, such as natural killer cells and the complement system, which are active also in syngeneic recipients, appear to preferentially reject undifferentiated cells. This effect could reduce the risk of tumor formation in immunocompetent recipients. Cell differentiation apparently increases susceptibility to rejection by the adaptive immune system in allogeneic hosts. The current data suggest that the immune system of the recipient has a major impact on the outcome of pluripotent stem cell transplantation, whether it is rejection, engraftment, or tumor development. This has to be considered when the results of experimental transplantation models are interpreted and even more when translation into clinics is planned