12 research outputs found
Ex vivo rehabilitation of non–heart-beating donor lungs in preclinical porcine model: Delayed perfusion results in superior lung function
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Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients
No full textProgress in environmental-friendly polymer nanocomposite material from PLA: Synthesis, processing and applications
No full textEndogenous adenosine maintains cartilage homeostasis and exogenous adenosine inhibits osteoarthritis progression
No full textCD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages
No full textNew insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptors
No full textImmunogenic cell death and DAMPs in cancer therapy
No full textAlthough it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent death that did not trigger an immune response, in recent years a new concept of immunogenic cell death (ICD) has emerged. The immunogenic characteristics of ICD are mainly mediated by damage-associated molecular patterns (DAMPs), which include surface-exposed calreticulin (CRT), secreted ATP and released high mobility group protein B1 (HMGB1). Most DAMPs can be recognized by pattern recognition receptors (PRRs). In this Review, we discuss the role of endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in regulating the immunogenicity of dying cancer cells and the effect of therapy-resistant cancer microevolution on ICD
