Intravesical Treatments of Bladder Cancer: Review

For bladder cancer, intravesical chemo/immunotherapy is widely used as adjuvant therapies after surgical transurethal resection, while systemic therapy is typically reserved for higher stage, muscle-invading, or metastatic diseases. The goal of intravesical therapy is to eradicate existing or residual tumors through direct cytoablation or immunostimulation. The unique properties of the urinary bladder render it a fertile ground for evaluating additional novel experimental approaches to regional therapy, including iontophoresis/electrophoresis, local hyperthermia, co-administration of permeation enhancers, bioadhesive carriers, magnetic-targeted particles and gene therapy. Furthermore, due to its unique anatomical properties, the drug concentration-time profiles in various layers of bladder tissues during and after intravesical therapy can be described by mathematical models comprised of drug disposition and transport kinetic parameters. The drug delivery data, in turn, can be combined with the effective drug exposure to infer treatment efficacy and thereby assists the selection of optimal regimens. To our knowledge, intravesical therapy of bladder cancer represents the first example where computational pharmacological approach was used to design, and successfully predicted the outcome of, a randomized phase III trial (using mitomycin C). This review summarizes the pharmacological principles and the current status of intravesical therapy, and the application of computation to optimize the drug delivery to target sites and the treatment efficacy

Role of nanotechnology in regeneration of pulpo-dentinal complex

Nanotechnology has completely revolutionized the field of Dentistry with enormous applications and opened up ample research opportunities in the field. Most research activities in Endodontics are performed in pursuit of regeneration of pulpo-dentinal complex. As in other fields, nanotechnology has ameliorated regenerative Endodontics and has brought about considerable promise to the field. Application of nanotechnology could even increase thesuccess rate of regeneration owing to biomimetic modifications in stem cells and scaffolds, which may soon be translated to clinical practice. This review highlights the important research activities in regeneration of dental pulp in collaboration with nanotechnology

Investigations on cold spray tungsten/tantalum coatings for plasma facing applications

Cold gas spraying for the production of thick tungsten (W) coatings has been investigated for use at plasma facing components in fusion devices. Since the brittle nature of W strongly impedes its deposition, a systematic study was performed using mixtures of tungsten and tantalum (Ta) powders. Whereas the use of 100% W powder was not successful yet, 2 mm thick coatings on steel were produced by using a W/Ta powder mixture with 90 vol% W, yielding a W content in the coating of 70 vol%. The coatings show negligible porosity and very good adhesion to the substrate. High heat flux experiments on samples with the size 80 × 80 mm2 were performed in order to investigate the behaviour under low (≤4 MW/m2) steady state loads and high power (∼40 MW/m2) transients. During the pulses with low power density, being typical for applications at the main chamber first wall, no defects were observed and a thermal conductivity close to that of the bulk materials was found. During the high power transients lasting for 200 ms cracks parallel to the surface appeared inside the coating