Community-based control of a neglected tropical disease: the mossy foot treatment and prevention association

Podoconiosis (endemic non-filarial elephantiasis, also known as mossy foot) is a non-communicable disease now found exclusively in the tropics, caused by the conjunction of environmental, genetic, and economic factors. Silicate particles formed by the disintegration of lava in areas of high altitude (over 1,000 m) and seasonal rainfall (over 1,000 mm per annum) penetrate the skin of barefoot subsistence farmers, and in susceptible individuals cause lymphatic blockage and subsequent elephantiasis [1]. Although an estimated one million Ethiopians (of a total population of 77 million) are afflicted with podoconiosis [2], which creates a huge economic burden in endemic areas [3], no national policy has yet been developed to control or prevent the condition, and most affected communities remain unaware of treatment options

A systematic review of population health interventions and Scheduled Tribes in India

<p>Abstract</p> <p>Background</p> <p>Despite India's recent economic growth, health and human development indicators of Scheduled Tribes (ST) or <it>Adivasi </it>(India's indigenous populations) lag behind national averages. The aim of this review was to identify the public health interventions or components of these interventions that are effective in reducing morbidity or mortality rates and reducing risks of ill health among ST populations in India, in order to inform policy and to identify important research gaps.</p> <p>Methods</p> <p>We systematically searched and assessed peer-reviewed literature on evaluations or intervention studies of a population health intervention undertaken with an ST population or in a tribal area, with a population health outcome(s), and involving primary data collection.</p> <p>Results</p> <p>The evidence compiled in this review revealed three issues that promote effective public health interventions with STs: (1) to develop and implement interventions that are low-cost, give rapid results and can be easily administered, (2): a multi-pronged approach, and (3): involve ST populations in the intervention.</p> <p>Conclusion</p> <p>While there is a growing body of knowledge on the health needs of STs, there is a paucity of data on how we can address these needs. We provide suggestions on how to undertake future population health intervention research with ST populations and offer priority research avenues that will help to address our knowledge gap in this area.</p

Three way translocation in a new variant of t(8;21) acute myeloid leukemia involving Xp22

The t(8;21)(q22;q22) is one of the most frequent chromosomal abnormality associated with acute myeloid leukemia (AML) M2 sub type. The additional chromosomal abnormalities including structural and numerical are frequently reported with the translocation, t (8;21)(q22;q22). We report a case of AML-M2 with t(X;8;21)(p22;q22;q22) associated with loss of Y chromosome. Using a dual color fluorescence in situ hybridization (FISH) analysis with ETO and AML1 probes, we demonstrated an ETO/AML1 fusion signal on the derivative chromosome 8 and one ETO signal on derivative Chromosome Xp22. The patient did not respond to therapy and follow-up of cytogenetics revealed same chromosome abnormality. Hence, this three way translocation involving X chromosome might be associated with poor prognosis

Three way translocation in a new variant of t(8;21) acute myeloid leukemia involving Xp22

The t(8;21)(q22;q22) is one of the most frequent chromosomal abnormality associated with acute myeloid leukemia (AML) M2 sub type. The additional chromosomal abnormalities including structural and numerical are frequently reported with the translocation, t (8;21)(q22;q22). We report a case of AML-M2 with t(X;8;21)(p22;q22;q22) associated with loss of Y chromosome. Using a dual color fluorescence in situ hybridization (FISH) analysis with ETO and AML1 probes, we demonstrated an ETO/AML1 fusion signal on the derivative chromosome 8 and one ETO signal on derivative Chromosome Xp22. The patient did not respond to therapy and follow-up of cytogenetics revealed same chromosome abnormality. Hence, this three way translocation involving X chromosome might be associated with poor prognosis

Hepatoprotective effect of Curcuma longa against lead induced toxicity in Wistar rats

Aim: The present investigation has been conducted to evaluate the hepatoprotective effect of Curcuma longa against lead induced toxicity.Materials and Methods: For this study, 24 Wistar albino rats were taken. Control group (n=8), group – I rats (n=8) were given lead acetate @ 1000 mg/kg bodyweight (BW) and group – II rats (n=8) were treated with Curcuma longa @ 500 mg/kg BW along with lead acetate @ 1000 mg/kg BW (daily orally for 28 days). Serum biomarkers, oxidative stress parameters and lead concentration in liver were estimated.Results: Oral administration of lead acetate for 28 days resulted in a significant increase in Aspartate amino transferase (AST), Alanine amino transferase (ALT), Alkaline phosphatase (ALP), significant increase of Lipid peroxidation (LPO) and decrease in Superoxide dismutase (SOD), Reduced glutathione (GSH) and increase in lead accumulation in liver. Treatment with Curcuma longa@ 500 mg/kg BWsignificantly (P< 0.01) decreased the elevated ALP, (p< 0.05) AST, ALT, LPO levels and increase in GSH levels and as compared to lead acetate treated group. But there was no significant difference in SOD level and lead concentration in liver when compared with lead acetate treated group.Conclusions: The study concludes that supplementation of Curcuma longa @ 500 mg/kg daily oral for 28 days has shown protection against lead inducedhepatotoxicit

Irrigation Management Strategies to Increase Crop-Water Productivity and Grain Quality of Direct Seeded Rice in North West IGP: A Review

Due to its great productivity and profitability, rice (Oryza sativa L.) is farmed in alluvial irrigated tracts of northwest India. For half of the world's population as well as in our country, rice serves as the main source of calories. However, excessive groundwater use in rice farming has resulted in an alarming decline in water table, indicating overuse of groundwater. Therefore, it is necessary to investigate alternative, resource-conserving methods that can sustain rice production. Direct seeded rice presents a compelling option when the future of rice production is in jeopardy due to worldwide water constraint and rising labour costs. The oldest method of crop establishment in this regard, direct seeded rice (DSR), is becoming more and more well-liked constraints minimal input requirements. It has certain benefits, including labour savings, a reduction in water and manpower requirements, early crop maturity, cheap production costs, improved soil physical conditions for crops, a reduction in methane emissions, and greater options for being the best match in various cropping systems. For dry-seeded rice, management strategies that cut irrigation water use and boost crop-water production are needed. Some of the interventions in this respect include cultivars with short growing seasons, tillage, and irrigation scheduling. High crop-water productivity is ensured with optimal yields thanks to irrigation scheduling that aims to eliminate over- or under-irrigation. Tillage changes the edaphic environment of the soil, which impacts crop development. Because of their shallow root systems, rice plants are unable to use the water in the deeper layers of the soil. In order to increase the deep root growth of rice cultivars, deep tillage has become the preferable method. The present research evaluates irrigation management options to raise crop-water productivity and grain quality of DSR in northwest IGP based on the available evidence