’Alright on the night?' Envisioning a ’night time economy’ in the Thames Gateway,

Providing a comprehensive overview and critique of the Thames Gateway plan, this volume examines the impact of urban planning and demographic change on East London's material and social environment

Semileptonic Lambda_b decay to excited Lambda_c baryons at order Lambda_{QCD}/m_Q

Exclusive semileptonic Lambda_b decays to excited charmed Lambda_c baryons are investigated at order Lambda_{QCD}/m_Q in the heavy quark effective theory. The differential decay rates are analyzed for the J^\pi=1/2^- Lambda_c(2593) and the J^\pi=3/2^- \Lambda_c(2625). They receive 1/m_{c,b} corrections at zero recoil that are determined by mass splittings and the leading order Isgur-Wise function. With some assumptions, we find that the branching fraction for Lambda_b decays to these states is 2.5-3.3%. The decay rate to the helicity \pm 3/2 states, which vanishes for m_Q \to \infty, remains small at order Lambda_{QCD}/m_Q since 1/m_c corrections do not contribute. Matrix elements of weak currents between a Lambda_b and other excited Lambda_c states are analyzed at zero-recoil to order Lambda_{QCD}/m_Q. Applications to baryonic heavy quark sum-rules are explored.Comment: 27 pages, 1 fig., minor changes, version to appear in Phys.Rev.

Castleman disease and lymphocytic interstitial pneumonia: a complex diagnostic and management challenge

No abstract available

Modelling the Self-Assembly of Virus Capsids

We use computer simulations to study a model, first proposed by Wales [1], for the reversible and monodisperse self-assembly of simple icosahedral virus capsid structures. The success and efficiency of assembly as a function of thermodynamic and geometric factors can be qualitatively related to the potential energy landscape structure of the assembling system. Even though the model is strongly coarse-grained, it exhibits a number of features also observed in experiments, such as sigmoidal assembly dynamics, hysteresis in capsid formation and numerous kinetic traps. We also investigate the effect of macromolecular crowding on the assembly dynamics. Crowding agents generally reduce capsid yields at optimal conditions for non-crowded assembly, but may increase yields for parameter regimes away from the optimum. Finally, we generalize the model to a larger triangulation number T = 3, and observe more complex assembly dynamics than that seen for the original T = 1 model.Comment: 16 pages, 11 figure

The effects of machining process variables and tooling characterisation on the surface generation: modelling, simulation and application promise

The paper presents a novel approach for modelling and simulation of the surface generation in the machining process. The approach, by integrating dynamic cutting force model, regenerative vibration model, machining system response model and tool profile model, models the complex surface generation process. Matlab Simulink is used to interactively perform the simulation in a user-friendly, effective and efficient manner. The effects of machining variables and tooling characteristics on the surface generation are investigated through simulations. CNC turning trials have been carried out to evaluate and validate the approach and simulations presented. The proposed approach contributes to comprehensive and better understanding of the machining system, and is promising for industrial applications with particular reference to the optimisation of the machining process based on the product/component surface functionality requirements

Why are Some Regions More Innovative than Others? The Role of Firm Size Diversity

Large labs may spawn spin-outs caused by innovations deemed unrelated to the firm's overall business. Small labs generate demand for specialized services that lower entry costs for others. We develop a theoretical framework to study the interplay of these two localized externalities and their impact on regional innovation. We examine MSA-level patent data during the period 1975-2000 and find that innovation output is higher where large and small labs coexist. The finding is robust to across-region as well as within-region analysis, IV analysis, and the effect is stronger in certain subsamples consistent with our explanation but not the plausible alternatives.

Validation of a revised form of the Dysfunctional Attitude Scale in a clinical population.

The Dysfunctional Attitude Scale (Weissman, 1979) is purported to measure the idiosyncratic cognitive schemas hypothesized by Beck (1967) to be involved in depression. Swan (1988) reduced this scale to develop a 20 item rapid assessment instrument (DAS-20). The purpose of the present study was to validate the DAS-20 in a clinical population. The DAS-20 was administered along with the Beck Depression Inventory (BDI) and the Profile of Mood States (POMS) to three subject groups (Depressive Disorder patients, Panic Disorder patients, and normal controls). For clinical subjects, scores on the DAS-20 were found to be most highly related to depressive symptomatology, as measured by the BDI (r =.51). Control subjects\u27 DAS-20 scores were most highly related to the confusion scale of the POMS (r =.56). The DAS-20 discriminated between clinical and control groups, but not between the two clinical groups themselves. It was concluded that in clinical populations dysfunctional attitudes, as measured by the DAS-20, are primarily related to syndrome depression rather than nosological Depressive Disorders.Dept. of Psychology. Paper copy at Leddy Library: Theses & Major Papers - Basement, West Bldg. / Call Number: Thesis1990 .T933. Source: Masters Abstracts International, Volume: 30-03, page: 0892. Thesis (M.A.)--University of Windsor (Canada), 1989