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Irradiation study of a fully monolithic HV-CMOS pixel sensor design in AMS 180 nm
High-Voltage Monolithic Active Pixel Sensors (HV-MAPS) based on the 180 nm
HV-CMOS process have been proposed to realize thin, fast and highly integrated
pixel sensors. The MuPix7 prototype, fabricated in the commercial AMS H18
process, features a fully integrated on-chip readout, i.e. hit-digitization,
zero suppression and data serialization. It is the first fully monolithic
HV-CMOS pixel sensor that has been tested for the use in high irradiation
environments like HL-LHC. We present results from laboratory and test beam
measurements of MuPix7 prototypes irradiated with neutrons (up to
) and protons (up to ) and compare the performance with non-irradiated
sensors. Efficiencies well above 90 % at noise rates below 200 Hz per pixel are
measured. A time resolution better than 22 ns is measured for all tested
settings and sensors, even at the highest irradiation fluences. The data
transmission at 1.25 Gbit/s and the on-chip PLL remain fully functional
The MuPix Telescope: A Thin, high Rate Tracking Telescope
The MuPix Telescope is a particle tracking telescope, optimized for tracking
low momentum particles and high rates. It is based on the novel High-Voltage
Monolithic Active Pixel Sensors (HV-MAPS), designed for the Mu3e tracking
detector. The telescope represents a first application of the HV-MAPS
technology and also serves as test bed of the Mu3e readout chain. The telescope
consists of up to eight layers of the newest prototypes, the MuPix7 sensors,
which send data self-triggered via fast serial links to FPGAs, where the data
is time-ordered and sent to the PC. A particle hit rate of 1 MHz per layer
could be processed. Online tracking is performed with a subset of the incoming
data. The general concept of the telescope, chip architecture, readout concept
and online reconstruction are described. The performance of the sensor and of
the telescope during test beam measurements are presented.Comment: Proceedings TWEPP 2016, 8 pages, 7 figure
MuPix7 - A fast monolithic HV-CMOS pixel chip for Mu3e
The MuPix7 chip is a monolithic HV-CMOS pixel chip, thinned down to 50 \mu m.
It provides continuous self-triggered, non-shuttered readout at rates up to 30
Mhits/chip of 3x3 mm^2 active area and a pixel size of 103x80 \mu m^2. The hit
efficiency depends on the chosen working point. Settings with a power
consumption of 300 mW/cm^2 allow for a hit efficiency >99.5%. A time resolution
of 14.2 ns (Gaussian sigma) is achieved. Latest results from 2016 test beam
campaigns are shown.Comment: Proceedingsfor the PIXEL2016 conference, submitted to JINST A
dangling reference has been removed from this version, no other change
Deep phenotyping of the unselected COPSAC2010 birth cohort study
BACKGROUND: We hypothesize that perinatal exposures, in particular the human microbiome and maternal nutrition during pregnancy, interact with the genetic predisposition to cause an abnormal immune modulation in early life towards a trajectory to chronic inflammatory diseases such as asthma and others. OBJECTIVE: The aim of this study is to explore these interactions by conducting a longitudinal study in an unselected cohort of pregnant women and their offspring with emphasis on deep clinical phenotyping, exposure assessment, and biobanking. Exposure assessments focus on the human microbiome. Nutritional intervention during pregnancy in randomized controlled trials are included in the study to prevent disease and to be able to establish causal relationships. METHODS: Pregnant women from eastern Denmark were invited during 2008â2010 to a novel unselected âCOPSAC(2010)â cohort. The women visited the clinic during pregnancy weeks 24 and 36. Their children were followed at the clinic with deep phenotyping and collection of biological samples at nine regular visits until the age of 3 and at acute symptoms. Randomized controlled trials of highâdose vitamin D and fish oil supplements were conducted during pregnancy, and a trial of azithromycin for acute lung symptoms was conducted in the children with recurrent wheeze. RESULTS: Seven hundred and thirtyâeight mothers were recruited from week 24 of gestation, and 700 of their children were included in the birth cohort. The cohort has an overârepresentation of atopic parents. The participant satisfaction was high and the adherence equally high with 685 children (98%) attending the 1 year clinic visit and 667 children (95%) attending the 2 year clinic visit. CONCLUSIONS: The COPSAC(2010) birth cohort study provides longitudinal clinical followâup with highly specific endâpoints, exposure assessments, and biobanking. The cohort has a high adherence rate promising strong data to elucidate the interaction between genomics and the exposome in perinatal life leading to lifestyleârelated chronic inflammatory disorders such as asthma
Interleukin-8 Is Activated in Patients with Chronic Liver Diseases and Associated with Hepatic Macrophage Accumulation in Human Liver Fibrosis
BACKGROUND: Interleukin-8 (IL-8, CXCL8) is a potent chemoattractant for neutrophils and contributes to acute liver inflammation. Much less is known about IL-8 in chronic liver diseases (CLD), but elevated levels were reported from alcoholic and hepatitis C-related CLD. We investigated the regulation of IL-8, its receptors CXCR1 and CXCR2 and possible IL-8 responding cells in CLD patients. METHODOLOGY: Serum IL-8 levels were measured in CLD patients (nâ=â200) and healthy controls (nâ=â141). Intrahepatic IL-8, CXCR1 and CXCR2 gene expression was quantified from liver samples (nâ=â41), alongside immunohistochemical neutrophil (MPO) and macrophage (CD68) stainings. CXCR1 and CXCR2 expression was analyzed on purified monocytes from patients (nâ=â111) and controls (nâ=â31). In vitro analyses explored IL-8 secretion by different leukocyte subsets. PRINCIPAL FINDINGS: IL-8 serum levels were significantly increased in CLD patients, especially in end-stage cirrhosis. Interestingly, patients with cholestatic diseases exhibited highest IL-8 serum concentrations. IL-8 correlated with liver function, inflammatory cytokines and non-invasive fibrosis markers. Intrahepatically, IL-8 and CXCR1 expression were strongly up-regulated. However, intrahepatic IL-8 could only be associated to neutrophil infiltration in patients with primary biliary cirrhosis (PBC). In non-cholestatic cirrhosis, increased IL-8 and CXCR1 levels were associated with hepatic macrophage accumulation. In line, CXCR1, but not CXCR2 or CXCR3, expression was increased on circulating monocytes from cirrhotic patients. Moreover, monocyte-derived macrophages from CLD patients, especially the non-classical CD16âș subtype, displayed enhanced IL-8 secretion in vitro. CONCLUSIONS: IL-8 is strongly activated in CLD, thus likely contributing to hepatic inflammation. Our study suggests a novel role of IL-8 for recruitment and activation of hepatic macrophages via CXCR1 in human liver cirrhosis
CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization
Biopharmaceutic
Technical design of the phase I Mu3e experiment
The Mu3e experiment aims to find or exclude the lepton flavour violating
decay at branching fractions above . A first
phase of the experiment using an existing beamline at the Paul Scherrer
Institute (PSI) is designed to reach a single event sensitivity of . We present an overview of all aspects of the technical design and
expected performance of the phase~I Mu3e detector. The high rate of up to
muon decays per second and the low momenta of the decay electrons and
positrons pose a unique set of challenges, which we tackle using an ultra thin
tracking detector based on high-voltage monolithic active pixel sensors
combined with scintillating fibres and tiles for precise timing measurements.Comment: 114 pages, 185 figures. Submitted to Nuclear Instruments and Methods
A. Edited by Frank Meier Aeschbacher This version has many enhancements for
better readability and more detail
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