A GMRT 150 MHz search for variables and transients in Stripe 82

We have carried out a dedicated transient survey of 300 deg2 of the SDSS Stripe 82 region using the Giant Metrewave Radio Telescope (GMRT) at 150 MHz. Our multi-epoch observations, together with the TGSS survey, allow us to probe variability and transient activity on four different time-scales, beginning with 4 h and up to 4 yr. Data calibration, RFI flagging, source finding, and transient search were carried out in a semi-automated pipeline incorporating the SPAM recipe. This has enabled us to produce superior-quality images and carry out reliable transient search over the entire survey region in under 48 h post-observation. Among the few thousand unique point sources found in our 5σ single-epoch catalogues (flux density thresholds of about 24, 20, 16, and 18 mJy on the respective time-scales), we find <0.08 per cent, 0.01 per cent, <0.06 per cent, and 0.05 per cent to be variable (beyond a significance of 4σ and fractional variability of 30 per cent) on time-scales of 4 h, 1 d, 1 month, and 4 yr, respectively. This is substantially lower than that in the GHz sky, where ∼1 per cent of the persistent point sources are found to be variable. Although our survey was designed to probe a superior part of the transient phase space, our transient search did not yield any significant candidates. The transient (preferentially extragalactic) rate at 150 MHz is therefore <0.005 on time-scales of 1 month and 4 yr, and <0.002 on time-scales of 1 d and 4 h, beyond 7σ detection threshold. We put these results in perspective with the previous studies and give recommendations for future low-frequency transient surveys

Are probiotics a feasible intervention for prevention of diarrhoea in the developing world?

With more than 1.4 million of the 9 million child deaths being attributed to diarrhoea in 2008 and 49% of them occurring in five countries namely, India, Nigeria, Democratic Republic of the Congo, Pakistan and China, there is an urgent need for intervention to prevent and control diarrhoeal diseases. Of the various interventions, probiotics offer immense potential. The past decade has witnessed the validation of their utility for the prevention, treatment and management of a variety of infective and non infective disorders. The most investigated field continues to remain infectious diarrhoea and compelling evidence comes from randomized placebo controlled trials. While results from these studies are encouraging most of them reflect the outcomes of the developed world. Developing countries like India continue to struggle with nutritional and health challenges and bear the greatest burden of diarrhoea. A paucity of data from the developing countries limits the definite recommendation of probiotics. In these countries curd, often confused for a probiotic, is practiced as an integral part of the culture. While the nutritional benefits of these products cannot be understated, it is still uncertain whether these products can be classified as a probiotic. The emergence of probiotic foods which are scientifically validated for their efficacy and impart defined health benefits offer an excellent opportunity to improve public health. A recent randomized controlled trial conducted by the National Institute of Cholera and Enteric Diseases in Kolkata, India demonstrated a protective efficacy of 14% in preventing diarrhoea among children who received a probiotic. For the developing world however the vision for probiotics would mean a fundamental change in perception and developing a well planned strategy to allow interventions like probiotics to permeate to impoverished settings, where the assault of micro organisms is on a daily basis. This would mean that probiotics are ingrained into the public health system without being seen as a medicine

Health impact of probiotics - vision and opportunities

Our understanding of the role of the microbiota in our gut and other sites in our body is rapidly emerging and could lead to many new and innovative approaches for health care. The promise of the potential role of probiotics for the prevention and treatment of enteric and other infections as an effective solution needs to be realized. The meeting report summarizes the insights and learning from a recent symposium, "Health Impact of Probiotics - Vision and Opportunities" conducted in Mumbai by the Yakult India Microbiota and Probiotic Science Foundation and P.D. Hinduja National Hospital, Mumbai. The symposium reflected its objective of unraveling the potential role of probiotics for health benefits through presentations and discussions. Experts clearly highlighted the role of probiotics in improving various aspects of health and in immune modulation. The report also captures the debate and discussions on the challenges that are likely to be encountered for the use of probiotics in the country

Immune Responses to Defined Plasmodium Falciparum Antigens and Disease Susceptibility in Two Subpopulations of Northern India

The aim of this study was to investigate the prevalence of naturally acquired immune response to malaria in individuals of different age groups belonging to areas of northern India, Loni PHC (LN) and Dhaulana PHC (SD) of district Ghaziabad. Plasmodium falciparum-infected erythrocyte lysate and six synthetic peptides from different stages of P. falciparum (CSP, MSP1, AMA1, RAP1, EBA175 and PfG27) were used to determine both humoral and cellular immune responses. Plasma of individual subject was also analyzed for IL-4, IL-10, IFN-γ and TNF-α level. We observed an age-wise increasing trend of immunity in these two populations. There was a significant association between the number of antibody responders and recognition of stage-specific epitopes by antibodies. Peripheral blood mononuclear cells of more than 75% of individuals proliferated in response to stimulation by all the antigens in LN area. IL-4 and IL-10 responses were significantly higher in individuals of LN Area; whereas IFN-g and &nbsp;&nbsp;TNF-a responses were higher in individuals of SD Area. It was also noticed that the frequency of responders to stage-specific antigens was higher in individuals from the LN area where the frequency of malaria was lower. The naturally acquired immune responses to P. falciparum antigens reflected the reduced risk of malaria in the study groups. The results demonstrated immunogenicity of the epitopes to P. falciparum in population of this endemic zone

A GMRT 150 MHz Search for Variables and Transients in Stripe 82

We have carried out a dedicated transient survey of 300 deg$^2$ of the SDSS Stripe 82 region using the Giant Meterwavelength Radio Telescope (GMRT) at 150 MHz. Our multi-epoch observations, together with the TGSS survey, allow us to probe variability and transient activity on four different timescales, beginning with 4 hours, and up to 4 years. Data calibration, RFI flagging, source finding and transient search were carried out in a semi-automated pipeline incorporating the SPAM recipe. This has enabled us to produce superior-quality images and carry out reliable transient search over the entire survey region in under 48 hours post-observation. Among the few thousand unique point sources found in our 5$\sigma$ single-epoch catalogs (flux density thresholds of about 24 mJy, 20 mJy, 16 mJy and 18 mJy on the respective timescales), we find $<$0.08%, 0.01%, $<$0.06% and 0.05% to be variable (beyond a significance of 4$\sigma$ and fractional variability of 30%) on timescales of 4 hours, 1 day, 1 month and 4 years respectively. This is substantially lower than that in the GHz sky, where $\sim$1% of the persistent point sources are found to be variable. Although our survey was designed to probe a superior part of the transient phase space, our transient sources did not yield any significant candidates. The transient (preferentially extragalactic) rate at 150 MHz is therefore $<$0.005 on timescales of 1 month and 4 years, and $<$0.002 on timescales of 1 day and 4 hours, beyond 7$\sigma$ detection threshold. We put these results in the perspective with the previous studies and give recommendations for future low-frequency transient surveys.Comment: 9 pages, 7 figures. Published in MNRAS; doi: 10.1093/mnras/stz291

Burden, maternal risk factors, and fetal outcomes in twin pregnancies: a retrospective observational study

Background: Twin pregnancies present significant challenges for obstetricians worldwide. Although they account for a relatively small percentage of global births, their occurrence varies across different regions. The increasing utilization of assisted reproduction techniques and the advancing maternal age contribute to the growing incidence of twin pregnancies. As a result, it is essential to understand the implications and risks associated with multiple gestations. The objective was to determine the burden of twin pregnancies, identify maternal risk factors, assess fetal outcomes, and explore potential associations between these factors. Methods: Data were collected from hospital records, including information on maternal age, parity, method of conception, gestational age, pregestational body mass index (BMI), and family history. Maternal and fetal complications, mode of delivery, and high-risk conditions in the fetuses were documented. Statistical analysis was performed using the Fisher-exact test. Results: The study included 78 twin pregnancies. The majority of women (78.2%) fell within the age range of 21-30 years. The majority of women (70.5%) had a normal pregestational BMI. Preterm births occurred in 24.3% of twin pregnancies. Hypertensive disorders (24.0%) and foetal malpresentation (38.0%) were common indications for cesarean section. Fetal complications included intrauterine growth restriction (11.5%), birth weight discordance (25.0%), early neonatal deaths (14.7%), and low APGAR scores (16.0%). Conclusions: Twin pregnancies present challenges due to the increased risks of maternal complications, preterm birth, and adverse fetal outcomes. The study emphasizes the need for careful management and monitoring of twin pregnancies to improve outcomes

Strategies for using cellular automata to locate constrained layer damping on vibrating structures

It is often hard to optimise constrained layer damping (CLD) for structures more complicated than simple beams and plates as its performance depends on its location, the shape of the applied patch, the mode shapes of the structure and the material properties. This paper considers the use of cellular automata (CA) in conjunction with finite element analysis to obtain an efficient coverage of CLD on structures. The effectiveness of several different sets of local rules governing the CA are compared against each other for a structure with known optimum coverage-namely a plate. The algorithm which attempts to replicate most closely known optimal configurations is considered the most successful. This algorithm is then used to generate an efficient CLD treatment that targets several modes of a curved composite panel. To validate the modelling approaches used, results are also presented of a comparison between theoretical and experimentally obtained modal properties of the damped curved panel

A Decline in the X-ray through Radio Emission from GW170817 Continues to Support an Off-Axis Structured Jet

We present new observations of the binary neutron star merger GW170817 at $\Delta t\approx 220-290$ days post-merger, at radio (Karl G. Jansky Very Large Array; VLA), X-ray (Chandra X-ray Observatory) and optical (Hubble Space Telescope; HST) wavelengths. These observations provide the first evidence for a turnover in the X-ray light curve, mirroring a decline in the radio emission at $\gtrsim5\sigma$ significance. The radio-to-X-ray spectral energy distribution exhibits no evolution into the declining phase. Our full multi-wavelength dataset is consistent with the predicted behavior of our previously published models of a successful structured jet expanding into a low-density circumbinary medium, but pure cocoon models with a choked jet cannot be ruled out. If future observations continue to track our predictions, we expect that the radio and X-ray emission will remain detectable until $\sim 1000$ days post-merger.Comment: Accepted to ApJL. Updated version includes new VLA observations extending through 2018 June

The Binary Neutron Star event LIGO/VIRGO GW170817 a hundred and sixty days after merger: synchrotron emission across the electromagnetic spectrum

We report deep Chandra, HST and VLA observations of the binary neutron star event GW170817 at $t<160$ d after merger. These observations show that GW170817 has been steadily brightening with time and might have now reached its peak, and constrain the emission process as non-thermal synchrotron emission where the cooling frequency $\nu_c$ is above the X-ray band and the synchrotron frequency $\nu_m$ is below the radio band. The very simple power-law spectrum extending for eight orders of magnitude in frequency enables the most precise measurement of the index $p$ of the distribution of non-thermal relativistic electrons $N(\gamma)\propto \gamma^{-p}$ accelerated by a shock launched by a NS-NS merger to date. We find $p=2.17\pm0.01$, which indicates that radiation from ejecta with $\Gamma\sim3-10$ dominates the observed emission. While constraining the nature of the emission process, these observations do \emph{not} constrain the nature of the relativistic ejecta. We employ simulations of explosive outflows launched in NS ejecta clouds to show that the spectral and temporal evolution of the non-thermal emission from GW170817 is consistent with both emission from radially stratified quasi-spherical ejecta traveling at mildly relativistic speeds, \emph{and} emission from off-axis collimated ejecta characterized by a narrow cone of ultra-relativistic material with slower wings extending to larger angles. In the latter scenario, GW170817 harbored a normal SGRB directed away from our line of sight. Observations at $t\le 200$ days are unlikely to settle the debate as in both scenarios the observed emission is effectively dominated by radiation from mildly relativistic material.Comment: Updated with the latest VLA and Chandra dat

Optical polarization reveals colliding stellar stream shocks in a tidal disruption event

Supermassive black holes have been known to disrupt passing stars producing outbursts called Tidal Disruption Events offering a unique view on the early stages of accretion disk and jet formation. The advent of large scale optical time-domain surveys has significantly increased the number of known events and challenged our understanding of their dynamics and emission processes. Here, we present the linear polarization curve of the most polarized tidal disruption without any indication of contribution from a jet to the emission. Our observations demonstrate that optical TDE emission can be powered by tidal stream shocks.Comment: 36 pages, 7 figures, author's version of the paper accepted in Scienc