17 research outputs found
Quantum criticality and first-order transitions in the extended periodic Anderson model
We investigate the behavior of the periodic Anderson model in the presence of
- Coulomb interaction () using mean-field theory, variational
calculation, and exact diagonalization of finite chains. The variational
approach based on the Gutzwiller trial wave function gives a critical value of
and two quantum critical points (QCPs), where the valence
susceptibility diverges. We derive the critical exponent for the valence
susceptibility and investigate how the position of the QCP depends on the other
parameters of the Hamiltonian. For larger values of , the Kondo regime
is bounded by two first-order transitions. These first-order transitions merge
into a triple point at a certain value of . For even larger
valence skipping occurs. Although the other methods do not give a critical
point, they support this scenario.Comment: 8 pages, 7 figure
Identification of galectin-7 as a potential biomarker for esophageal squamous cell carcinoma by proteomic analysis
Ein Beitrag zum Sauerstoff- und Natriumverhalten im Produktionsprozess der Floatglasherstellung Schlussbericht
SIGLEAvailable from TIB Hannover: F04B1078 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekArbeitsgemeinschaft Industrieller Forschungsvereinigungen 'Otto von Guericke' e.V. (AIF), Koeln (Germany)DEGerman
FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer
The limited success of cancer immunotherapy is often attributed to the loss of antigen-specific T cell function in situ. However, the mechanism for this loss of function is unknown. In this study, we describe a population of tumor-associated DCs (TADCs) in both human and mouse prostate cancer that tolerizes and induces suppressive activity in tumor-specific T cells. In tumors from human prostate cancer patients and transgenic adenocarcinoma of the mouse prostate (TRAMP) mice, TADCs expressed elevated levels of FOXO3 and Foxo3, respectively, which correlated with expression of suppressive genes that negatively regulate T cell function. Silencing FOXO3 and Foxo3 with siRNAs abrogated the ability of human and mouse TADCs, respectively, to tolerize and induce suppressive activity by T cells. Silencing Foxo3 in mouse TADCs was also associated with diminished expression of tolerogenic mediators, such as indoleamine-2,3-dioxygenase, arginase, and TGF-β, and upregulated expression of costimulatory molecules and proinflammatory cytokines. Importantly, transfer of tumor-specific CD4+ Th cells into TRAMP mice abrogated TADC tolerogenicity, which was associated with reduced Foxo3 expression. These findings demonstrate that FOXO3 may play a critical role in mediating TADC-induced immune suppression. Moreover, our results identify what we believe to be a novel target for preventing CTL tolerance and enhancing immune responses to cancer by modulating the immunosuppressive activity of TADCs found in the tumor microenvironment